FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090906960> ?p ?o ?g. }

• W2090906960 endingPage "1997" @default.
• W2090906960 startingPage "1988" @default.
• W2090906960 abstract "We have previously shown that human IL-10-treated dendritic cells (DC) induce an antigen-specific anergy in CD4+ T lymphocytes. These anergic T cells are characterized by an inhibited proliferation, a reduced production of IL-2, and additionally display antigen-specific suppressor activity. In this study we investigated the mechanisms underlying the anergic state and regulatory function of these T cells. We did not observe enhanced rates of programmed cell death of anergic CD4+ suppressor T cells compared to T cells stimulated with mature DC. Cell cycle analysis by DNA staining and Western blot experiments revealed an arrest of anergic CD4+ T suppressor cells in the G1 phase. High levels of the IL-2-dependent cyclin-dependent kinase (cdk) inhibitor p27Kip1 were found in anergic CD4+ suppressor T cells resulting in an inhibited activation of retinoblastoma protein and an arrest of cell cycle progression in the G1 phase. Addition of IL-2, but not blocking of the CTLA-4 pathway restored the proliferation of the suppressor T cells. In contrast, both treatments induced a down-regulation of p27Kip1 and acomplete inhibition of the antigen-specific regulatory function as demonstrated by high proliferation and enhanced IFN-gamma production of co-cultured T cells. Further experiments demonstrated that p27Kip-expressing regulatory CD4+CD25+ T cells did not contribute to induction of T cell anergy in this model. Our data show that regulatory function of anergic CD4+ suppressor T cells is associated with an arrest in the G1 phase of the cell cycle mediated by increased levels of the IL-2- and CTLA-4-dependent cdk inhibitor p27Kip1." @default.
• W2090906960 created "2016-06-24" @default.
• W2090906960 creator A5006109801 @default.
• W2090906960 creator A5028682971 @default.
• W2090906960 creator A5045654278 @default.
• W2090906960 creator A5075254922 @default.
• W2090906960 date "2003-07-01" @default.
• W2090906960 modified "2023-10-13" @default.
• W2090906960 title "Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1" @default.
• W2090906960 cites W1482598749 @default.
• W2090906960 cites W1542616270 @default.
• W2090906960 cites W1564948430 @default.
• W2090906960 cites W1960538598 @default.
• W2090906960 cites W1967577988 @default.
• W2090906960 cites W1976945431 @default.
• W2090906960 cites W1979049274 @default.
• W2090906960 cites W1980720313 @default.
• W2090906960 cites W1986356667 @default.
• W2090906960 cites W1996413533 @default.
• W2090906960 cites W1997398245 @default.
• W2090906960 cites W1997708871 @default.
• W2090906960 cites W2001689055 @default.
• W2090906960 cites W2015066175 @default.
• W2090906960 cites W2034141629 @default.
• W2090906960 cites W2035793079 @default.
• W2090906960 cites W2044312503 @default.
• W2090906960 cites W2054419682 @default.
• W2090906960 cites W2054729047 @default.
• W2090906960 cites W2092104789 @default.
• W2090906960 cites W2099748840 @default.
• W2090906960 cites W2103592133 @default.
• W2090906960 cites W2111220263 @default.
• W2090906960 cites W2115855421 @default.
• W2090906960 cites W2137249911 @default.
• W2090906960 cites W2148245227 @default.
• W2090906960 cites W2154102317 @default.
• W2090906960 cites W2154953543 @default.
• W2090906960 cites W2158069920 @default.
• W2090906960 cites W2159987448 @default.
• W2090906960 cites W2170545257 @default.
• W2090906960 cites W2326775643 @default.
• W2090906960 cites W333385333 @default.
• W2090906960 doi "https://doi.org/10.1002/eji.200323600" @default.
• W2090906960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12884865" @default.
• W2090906960 hasPublicationYear "2003" @default.
• W2090906960 type Work @default.
• W2090906960 sameAs 2090906960 @default.
• W2090906960 citedByCount "75" @default.
• W2090906960 countsByYear W20909069602012 @default.
• W2090906960 countsByYear W20909069602013 @default.
• W2090906960 countsByYear W20909069602014 @default.
• W2090906960 countsByYear W20909069602015 @default.
• W2090906960 countsByYear W20909069602016 @default.
• W2090906960 countsByYear W20909069602017 @default.
• W2090906960 countsByYear W20909069602018 @default.
• W2090906960 countsByYear W20909069602019 @default.
• W2090906960 countsByYear W20909069602020 @default.
• W2090906960 countsByYear W20909069602021 @default.
• W2090906960 countsByYear W20909069602022 @default.
• W2090906960 countsByYear W20909069602023 @default.
• W2090906960 crossrefType "journal-article" @default.
• W2090906960 hasAuthorship W2090906960A5006109801 @default.
• W2090906960 hasAuthorship W2090906960A5028682971 @default.
• W2090906960 hasAuthorship W2090906960A5045654278 @default.
• W2090906960 hasAuthorship W2090906960A5075254922 @default.
• W2090906960 hasConcept C129374314 @default.
• W2090906960 hasConcept C147483822 @default.
• W2090906960 hasConcept C148125776 @default.
• W2090906960 hasConcept C153911025 @default.
• W2090906960 hasConcept C154317977 @default.
• W2090906960 hasConcept C167672396 @default.
• W2090906960 hasConcept C190283241 @default.
• W2090906960 hasConcept C202751555 @default.
• W2090906960 hasConcept C203014093 @default.
• W2090906960 hasConcept C2776090121 @default.
• W2090906960 hasConcept C29537977 @default.
• W2090906960 hasConcept C55493867 @default.
• W2090906960 hasConcept C67662055 @default.
• W2090906960 hasConcept C79484868 @default.
• W2090906960 hasConcept C86803240 @default.
• W2090906960 hasConcept C8891405 @default.
• W2090906960 hasConcept C95444343 @default.
• W2090906960 hasConceptScore W2090906960C129374314 @default.
• W2090906960 hasConceptScore W2090906960C147483822 @default.
• W2090906960 hasConceptScore W2090906960C148125776 @default.
• W2090906960 hasConceptScore W2090906960C153911025 @default.
• W2090906960 hasConceptScore W2090906960C154317977 @default.
• W2090906960 hasConceptScore W2090906960C167672396 @default.
• W2090906960 hasConceptScore W2090906960C190283241 @default.
• W2090906960 hasConceptScore W2090906960C202751555 @default.
• W2090906960 hasConceptScore W2090906960C203014093 @default.
• W2090906960 hasConceptScore W2090906960C2776090121 @default.
• W2090906960 hasConceptScore W2090906960C29537977 @default.
• W2090906960 hasConceptScore W2090906960C55493867 @default.
• W2090906960 hasConceptScore W2090906960C67662055 @default.
• W2090906960 hasConceptScore W2090906960C79484868 @default.
• W2090906960 hasConceptScore W2090906960C86803240 @default.
• W2090906960 hasConceptScore W2090906960C8891405 @default.

• next