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- W2090910412 abstract "Irritable bowel syndrome (IBS) involves a broad range of physiological and psychological alterations that may affect brain–gut dysregulation, gut function, visceral perception, and mucosal integrity and function. Despite advances in our understanding of basic neuroenteric mechanisms and the role of effectors and transmitters in the brain–gut axis, a reliable biologic marker of IBS has yet to be identified (1,2,3,4,5,6,7,8). IBS diagnosis and status depend entirely on an assessment of IBS signs and symptoms. This has made development of optimal end points and study design for evaluation of efficacy of IBS drugs a challenge. This article addresses three main topics: the evolution of primary end points for IBS clinical trials; a potential path forward for IBS end points in new clinical trials; and recommendations for the future development of patient-reported outcome (PRO) instruments for use in IBS clinical trials." @default.
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- W2090910412 date "2010-04-01" @default.
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- W2090910412 title "Evolution of Clinical Trials for Irritable Bowel Syndrome: Issues in End Points and Study Design" @default.
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- W2090910412 doi "https://doi.org/10.1038/ajg.2010.12" @default.
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