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• W2090913905 endingPage "e97007" @default.
• W2090913905 startingPage "e97007" @default.
• W2090913905 abstract "The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as inflammation and scar formation and cellular responses within the subventricular zone (SVZ) following transient focal ischemia in rats (n = 34). Endothelin-1-induced stroke resulted in neurological deficits detected between 1 and 7 days (P<0.001), but significant recovery was observed beyond this time. MCID image analysis revealed varying degrees of damage in the ipsilateral cortex and striatum with infarct volumes ranging from 0.76–77 mm3 after 14 days, where larger infarct volumes correlated with greater functional deficits up to 7 days (r = 0.53, P<0.05). Point counting of blood vessels within consistent sample regions revealed that increased vessel numbers correlated significantly with larger infarct volumes 14 days post-stroke in the core cortical infarct (r = 0.81, P<0.0001), core striatal infarct (r = 0.91, P<0.005) and surrounding border zones (r = 0.66, P<0.005; and r = 0.73, P<0.05). Cell proliferation within the SVZ also increased with infarct size (P<0.01) with a greater number of Nestin/GFAP positive cells observed extending towards the border zone in rats with larger infarcts. Lesion size correlated with both increased microglia and astrocyte activation, with severely diffuse astrocyte transition, the formation of the glial scar being more pronounced in rats with larger infarcts. Thus stroke severity affects cell proliferation within the SVZ in response to injury, which may ultimately make a further contribution to glial scar formation, an important factor to consider when developing treatment strategies that promote neurogenesis." @default.
• W2090913905 created "2016-06-24" @default.
• W2090913905 creator A5013646556 @default.
• W2090913905 creator A5017246405 @default.
• W2090913905 creator A5033895673 @default.
• W2090913905 creator A5042988931 @default.
• W2090913905 date "2014-05-08" @default.
• W2090913905 modified "2023-09-24" @default.
• W2090913905 title "Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats" @default.
• W2090913905 cites W1594425991 @default.
• W2090913905 cites W1965681567 @default.
• W2090913905 cites W1967626391 @default.
• W2090913905 cites W1969684909 @default.
• W2090913905 cites W1975017351 @default.
• W2090913905 cites W1977100729 @default.
• W2090913905 cites W1982737759 @default.
• W2090913905 cites W1983089266 @default.
• W2090913905 cites W1983725263 @default.
• W2090913905 cites W1989124810 @default.
• W2090913905 cites W1989560466 @default.
• W2090913905 cites W1990216374 @default.
• W2090913905 cites W1990814258 @default.
• W2090913905 cites W1999114461 @default.
• W2090913905 cites W1999494818 @default.
• W2090913905 cites W1999827700 @default.
• W2090913905 cites W2001908895 @default.
• W2090913905 cites W2005723160 @default.
• W2090913905 cites W2026983332 @default.
• W2090913905 cites W2029744927 @default.
• W2090913905 cites W2031006408 @default.
• W2090913905 cites W2032829222 @default.
• W2090913905 cites W2034967036 @default.
• W2090913905 cites W2046096265 @default.
• W2090913905 cites W2051021067 @default.
• W2090913905 cites W2055679077 @default.
• W2090913905 cites W205599847 @default.
• W2090913905 cites W2057269156 @default.
• W2090913905 cites W2061686604 @default.
• W2090913905 cites W2061705828 @default.
• W2090913905 cites W2067145343 @default.
• W2090913905 cites W2067267561 @default.
• W2090913905 cites W2069063688 @default.
• W2090913905 cites W2070558888 @default.
• W2090913905 cites W2071969118 @default.
• W2090913905 cites W2074474274 @default.
• W2090913905 cites W2074661552 @default.
• W2090913905 cites W2076659607 @default.
• W2090913905 cites W2077917860 @default.
• W2090913905 cites W2085424855 @default.
• W2090913905 cites W2088073775 @default.
• W2090913905 cites W2090804892 @default.
• W2090913905 cites W2091238235 @default.
• W2090913905 cites W2093728612 @default.
• W2090913905 cites W2101233757 @default.
• W2090913905 cites W2102247335 @default.
• W2090913905 cites W2103327450 @default.
• W2090913905 cites W2105711200 @default.
• W2090913905 cites W2106578597 @default.
• W2090913905 cites W2107752567 @default.
• W2090913905 cites W2107915390 @default.
• W2090913905 cites W2108188869 @default.
• W2090913905 cites W2109503237 @default.
• W2090913905 cites W2114303594 @default.
• W2090913905 cites W2116885817 @default.
• W2090913905 cites W2120231451 @default.
• W2090913905 cites W2122828560 @default.
• W2090913905 cites W2127338217 @default.
• W2090913905 cites W2129282529 @default.
• W2090913905 cites W2131032423 @default.
• W2090913905 cites W2133913526 @default.
• W2090913905 cites W2138394070 @default.
• W2090913905 cites W2140006134 @default.
• W2090913905 cites W2146085830 @default.
• W2090913905 cites W2146336916 @default.
• W2090913905 cites W2146417573 @default.
• W2090913905 cites W2148448757 @default.
• W2090913905 cites W2151551770 @default.
• W2090913905 cites W2155196554 @default.
• W2090913905 cites W2159916552 @default.
• W2090913905 cites W2165867905 @default.
• W2090913905 cites W2166487601 @default.
• W2090913905 cites W2168272960 @default.
• W2090913905 cites W2169079203 @default.
• W2090913905 cites W2792583460 @default.
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• W2090913905 doi "https://doi.org/10.1371/journal.pone.0097007" @default.
• W2090913905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4029108" @default.
• W2090913905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24809543" @default.
• W2090913905 hasPublicationYear "2014" @default.
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