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- W2090915944 abstract "Incompatibility of drug solutions administered through a common line may jeopardize the safety and effectiveness of i.v. drug therapies.1 We recently reported that, in the absence of dedicated preventive strategies, incompatibilities are alarmingly frequent in an intensive care setting.2 Hence, we developed and implemented a new standard operating procedure (SOP) governing frequently administered antibiotics that were often involved in incompatibilities (erythromycin, piperacillin–tazobactam, imipenem– cilastatin). In addition, the SOP made a general recommendation to use idle i.v. lines for infusion whenever available. This intervention was associated with a relative risk reduction of 23% for the administration of drug pairs via a common lumen, 58% for administration of incompatible pairs, and 74% for pairs governed by the new SOP (table).2 Catecholamines and analgesic–sedative drugs were not included in this analysis because their use was already standardized by SOPs. ... We reassessed the prevalence of incompatibilities on the same ward in a follow-up survey one year after implementation of the SOP. Since then, nurses of the ward, including new staff members, were advised monthly by the head nurse during the regular team meeting to follow the existing SOP. Actual drug administration was monitored in 53 consecutive ICU patients (mean ± S.D. age, 61.6 ± 15.8 years; 36% female) and incompatibilities were assessed using the same database as in the previous survey." @default.
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- W2090915944 date "2009-07-15" @default.
- W2090915944 modified "2023-09-24" @default.
- W2090915944 title "One-year follow-up on procedure to prevent i.v. drug incompatibilities in an intensive care unit" @default.
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- W2090915944 doi "https://doi.org/10.2146/ajhp090070" @default.
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