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- W2090919693 abstract "Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre-B cell leukemia and results in the formation of a fusion gene E2A-PBXI that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)-positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre-B cell leukemia. Genes Chromosom Cancer 10:171–176 (1994). © 1994 Wiley-Liss, Inc." @default.
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- W2090919693 date "1994-07-01" @default.
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- W2090919693 title "t(1;19) without detectableE2A rearrangements in two t(14; 18)-positive lymphoma/leukemia cases" @default.
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- W2090919693 doi "https://doi.org/10.1002/gcc.2870100304" @default.
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