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• W2090921817 abstract "The effect of a polyclonal anti-insulin receptor antibody (pIgG) on the insulin receptor tyrosine kinase (IRTK) activity toward poly-(Glu-Tyr) was examined using wheat germ agglutinin agarose-purified insulin receptors from rat liver membranes. The main effect of pIgG was a reduction of Vmax (from 60.8 to 31.8 pmol/min/mg), without changes of Km, when IRTK was activated by insulin. In contrast, when IRTK was activated by ATP preincubation, pIgG was unable to affect the reaction, suggesting that IRTK possesses at least two regulatory mechanisms, one of which can be affected by pIgG." @default.
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• W2090921817 date "1987-09-01" @default.
• W2090921817 modified "2023-10-18" @default.
• W2090921817 title "Regulation of insulin receptor-associated tyrosine kinase by a polyclonal IgG" @default.
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• W2090921817 doi "https://doi.org/10.1016/0303-7207(87)90186-9" @default.
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