FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090922849> ?p ?o ?g. }

• W2090922849 abstract "A live-attenuated, orally-administered, monovalent, human rotavirus vaccine, Rotarix® (GlaxoSmithKline Biologicals, Rixensart, Belgium), was licensed and launched in 2011 as the first rotavirus vaccine in Japan. The rotavirus causes a substantial disease burden with an estimated 790,000 outpatient visits, 27,000–78,000 hospitalizations, and approximately 10 deaths each year in Japan. Since a recent clinical trial showed that Rotarix was as efficacious in Japan as in other industrialized countries, it is expected that the annual number of rotavirus hospitalizations will be reduced to between 1000–3000, and that outpatient visits will be reduced to 200,000. The universal rotavirus immunization program with Rotarix was calculated to be at the threshold of being cost-effective, even from the healthcare perspective, and it was highly cost-effective from the societal perspective, assuming that Rotarix is co-administered with other childhood vaccines. While Rotarix contains only a single G1P[8] human rotavirus, the postlicensure studies in Brazil showed that Rotarix provided a 75%–85% protective efficacy against severe dehydrating diarrhea or hospitalizations due to fully-heterotypic G2P[4] strains. While postlicensure studies detected a small and finite risk of intussusception associated with the administration of Rotarix, the authors conclude that Rotarix is safe to administer to infants between 6-12 weeks of age for the first dose and by 24 weeks of age for the second dose. However, the authors strongly discourage the delayed administration of the first dose between 13-20 weeks of age, which is allowed without any warning. Given the high incidence of naturally-occurring intussusception in Japan (185 cases per 100,000 children/year among children less than 1 year of age), this should prevent pediatricians and parents from having ill-perceptions of Rotarix being associated with an increased number of temporally-associated intussusception, and fully appreciate the benefit of the rotavirus vaccine." @default.
• W2090922849 created "2016-06-24" @default.
• W2090922849 creator A5049436023 @default.
• W2090922849 creator A5090605115 @default.
• W2090922849 date "2011-09-01" @default.
• W2090922849 modified "2023-09-25" @default.
• W2090922849 title "Rotarix in Japan: Expectations and Concerns" @default.
• W2090922849 cites W1964705610 @default.
• W2090922849 cites W1965526538 @default.
• W2090922849 cites W1966419374 @default.
• W2090922849 cites W1973844430 @default.
• W2090922849 cites W1974362136 @default.
• W2090922849 cites W1974617413 @default.
• W2090922849 cites W1982661979 @default.
• W2090922849 cites W1985494124 @default.
• W2090922849 cites W1990226887 @default.
• W2090922849 cites W1996857400 @default.
• W2090922849 cites W2010271863 @default.
• W2090922849 cites W2019818689 @default.
• W2090922849 cites W2025825444 @default.
• W2090922849 cites W2026268041 @default.
• W2090922849 cites W2027227419 @default.
• W2090922849 cites W2029854306 @default.
• W2090922849 cites W2033338544 @default.
• W2090922849 cites W2035343531 @default.
• W2090922849 cites W2036573944 @default.
• W2090922849 cites W2038828844 @default.
• W2090922849 cites W2039403264 @default.
• W2090922849 cites W2040054827 @default.
• W2090922849 cites W2040393189 @default.
• W2090922849 cites W2044265671 @default.
• W2090922849 cites W2045795669 @default.
• W2090922849 cites W2060607350 @default.
• W2090922849 cites W2062810911 @default.
• W2090922849 cites W2072290173 @default.
• W2090922849 cites W2083934734 @default.
• W2090922849 cites W2089710044 @default.
• W2090922849 cites W2090392126 @default.
• W2090922849 cites W2092090915 @default.
• W2090922849 cites W2095820230 @default.
• W2090922849 cites W2099043392 @default.
• W2090922849 cites W2101100687 @default.
• W2090922849 cites W2103861589 @default.
• W2090922849 cites W2104964894 @default.
• W2090922849 cites W2105828340 @default.
• W2090922849 cites W2107362700 @default.
• W2090922849 cites W2109417543 @default.
• W2090922849 cites W2110027469 @default.
• W2090922849 cites W2110318366 @default.
• W2090922849 cites W2113014022 @default.
• W2090922849 cites W2126294698 @default.
• W2090922849 cites W2128330405 @default.
• W2090922849 cites W2128592628 @default.
• W2090922849 cites W2131154800 @default.
• W2090922849 cites W2143233237 @default.
• W2090922849 cites W2145655440 @default.
• W2090922849 cites W2156167673 @default.
• W2090922849 cites W2159396395 @default.
• W2090922849 cites W2164351608 @default.
• W2090922849 cites W2165170948 @default.
• W2090922849 cites W2167157173 @default.
• W2090922849 cites W2170749337 @default.
• W2090922849 cites W2333762130 @default.
• W2090922849 cites W3037826596 @default.
• W2090922849 cites W4236114911 @default.
• W2090922849 cites W4241579115 @default.
• W2090922849 cites W4362206875 @default.
• W2090922849 doi "https://doi.org/10.1007/s13554-011-0007-5" @default.
• W2090922849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3873079" @default.
• W2090922849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24392294" @default.
• W2090922849 hasPublicationYear "2011" @default.
• W2090922849 type Work @default.
• W2090922849 sameAs 2090922849 @default.
• W2090922849 citedByCount "1" @default.
• W2090922849 countsByYear W20909228492015 @default.
• W2090922849 crossrefType "journal-article" @default.
• W2090922849 hasAuthorship W2090922849A5049436023 @default.
• W2090922849 hasAuthorship W2090922849A5090605115 @default.
• W2090922849 hasBestOaLocation W20909228491 @default.
• W2090922849 hasConcept C126322002 @default.
• W2090922849 hasConcept C159047783 @default.
• W2090922849 hasConcept C187212893 @default.
• W2090922849 hasConcept C2777227250 @default.
• W2090922849 hasConcept C2779802037 @default.
• W2090922849 hasConcept C2781367151 @default.
• W2090922849 hasConcept C71924100 @default.
• W2090922849 hasConceptScore W2090922849C126322002 @default.
• W2090922849 hasConceptScore W2090922849C159047783 @default.
• W2090922849 hasConceptScore W2090922849C187212893 @default.
• W2090922849 hasConceptScore W2090922849C2777227250 @default.
• W2090922849 hasConceptScore W2090922849C2779802037 @default.
• W2090922849 hasConceptScore W2090922849C2781367151 @default.
• W2090922849 hasConceptScore W2090922849C71924100 @default.
• W2090922849 hasIssue "1" @default.
• W2090922849 hasLocation W20909228491 @default.
• W2090922849 hasLocation W20909228492 @default.
• W2090922849 hasLocation W20909228493 @default.
• W2090922849 hasLocation W20909228494 @default.
• W2090922849 hasOpenAccess W2090922849 @default.
• W2090922849 hasPrimaryLocation W20909228491 @default.

• next