FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090928900> ?p ?o ?g. }

• W2090928900 endingPage "208" @default.
• W2090928900 startingPage "199" @default.
• W2090928900 abstract "Levetiracetam (LEV) is a prominent antiepileptic drug that binds to neuronal synaptic vesicle glycoprotein 2A protein and has reported effects on ion channels, but with a poorly defined mechanism of action. We investigated inhibition of voltage-dependent Ca²⁺ (Ca_V) channels as a potential mechanism through which LEV exerts effects on neuronal activity. We used electrophysiological methods to investigate the effects of LEV on cholinergic synaptic transmission and Ca_V channel activity in superior cervical ganglion neurons (SCGNs). In parallel, we investigated the effects of the inactive LEV <i>R</i>-enantiomer, (<i>R</i>)-α-ethyl-2-oxo-1-pyrrolidine acetamide (UCB L060). LEV but not UCB L060 (each at 100 μM) inhibited synaptic transmission between SCGNs in long-term culture in a time-dependent manner, significantly reducing excitatory postsynaptic potentials after a ≥30-min application. In isolated SCGNs, LEV pretreatment (≥1 h) but not short-term application (5 min) significantly inhibited whole-cell Ba²⁺ current (I_Ba) amplitude. In current-clamp recordings, LEV reduced the amplitude of the afterhyperpolarizing potential in a Ca²⁺-dependent manner but also increased the action potential latency in a Ca²⁺-independent manner, which suggests additional mechanisms associated with reduced excitability. Intracellular LEV application (4–5 min) caused rapid inhibition of I_Ba amplitude, to an extent comparable to that seen with extracellular LEV pretreatment (≥1 h). Neither pretreatment nor intracellular application of UCB L060 produced any inhibitory effects on I_Ba amplitude. These results identify a stereospecific intracellular pathway through which LEV inhibits presynaptic Ca_V channels; resultant reductions in neuronal excitability are proposed to contribute to the anticonvulsant effects of LEV." @default.
• W2090928900 created "2016-06-24" @default.
• W2090928900 creator A5003343059 @default.
• W2090928900 creator A5039650196 @default.
• W2090928900 creator A5041519854 @default.
• W2090928900 creator A5046273039 @default.
• W2090928900 creator A5050056813 @default.
• W2090928900 date "2012-05-03" @default.
• W2090928900 modified "2023-09-25" @default.
• W2090928900 title "The Synaptic Vesicle Glycoprotein 2A Ligand Levetiracetam Inhibits Presynaptic Ca²⁺ Channels through an Intracellular Pathway" @default.
• W2090928900 cites W105915516 @default.
• W2090928900 cites W1498064496 @default.
• W2090928900 cites W1504181864 @default.
• W2090928900 cites W1546048845 @default.
• W2090928900 cites W1576738253 @default.
• W2090928900 cites W1975996573 @default.
• W2090928900 cites W1976575373 @default.
• W2090928900 cites W1978511926 @default.
• W2090928900 cites W1979298238 @default.
• W2090928900 cites W1981294852 @default.
• W2090928900 cites W1984209762 @default.
• W2090928900 cites W1990636181 @default.
• W2090928900 cites W1991772365 @default.
• W2090928900 cites W1991969184 @default.
• W2090928900 cites W1993009709 @default.
• W2090928900 cites W1999158779 @default.
• W2090928900 cites W2001243727 @default.
• W2090928900 cites W2003338471 @default.
• W2090928900 cites W2006693667 @default.
• W2090928900 cites W2009502669 @default.
• W2090928900 cites W2010990414 @default.
• W2090928900 cites W2011290849 @default.
• W2090928900 cites W2011785379 @default.
• W2090928900 cites W2015651475 @default.
• W2090928900 cites W2022919161 @default.
• W2090928900 cites W2023448340 @default.
• W2090928900 cites W2029085177 @default.
• W2090928900 cites W2034385122 @default.
• W2090928900 cites W2037655028 @default.
• W2090928900 cites W2039108005 @default.
• W2090928900 cites W2044492675 @default.
• W2090928900 cites W2055249621 @default.
• W2090928900 cites W2067463613 @default.
• W2090928900 cites W2075030357 @default.
• W2090928900 cites W2075156739 @default.
• W2090928900 cites W2080196512 @default.
• W2090928900 cites W2081897254 @default.
• W2090928900 cites W2090106870 @default.
• W2090928900 cites W2092977876 @default.
• W2090928900 cites W2095271866 @default.
• W2090928900 cites W2106929352 @default.
• W2090928900 cites W2107401900 @default.
• W2090928900 cites W2107514224 @default.
• W2090928900 cites W2118079454 @default.
• W2090928900 cites W2120228951 @default.
• W2090928900 cites W2122573606 @default.
• W2090928900 cites W2127801604 @default.
• W2090928900 cites W2132639205 @default.
• W2090928900 cites W2132807488 @default.
• W2090928900 cites W2151212002 @default.
• W2090928900 cites W2235505912 @default.
• W2090928900 doi "https://doi.org/10.1124/mol.111.076687" @default.
• W2090928900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22554805" @default.
• W2090928900 hasPublicationYear "2012" @default.
• W2090928900 type Work @default.
• W2090928900 sameAs 2090928900 @default.
• W2090928900 citedByCount "100" @default.
• W2090928900 countsByYear W20909289002012 @default.
• W2090928900 countsByYear W20909289002013 @default.
• W2090928900 countsByYear W20909289002014 @default.
• W2090928900 countsByYear W20909289002015 @default.
• W2090928900 countsByYear W20909289002016 @default.
• W2090928900 countsByYear W20909289002017 @default.
• W2090928900 countsByYear W20909289002018 @default.
• W2090928900 countsByYear W20909289002019 @default.
• W2090928900 countsByYear W20909289002020 @default.
• W2090928900 countsByYear W20909289002021 @default.
• W2090928900 countsByYear W20909289002022 @default.
• W2090928900 countsByYear W20909289002023 @default.
• W2090928900 crossrefType "journal-article" @default.
• W2090928900 hasAuthorship W2090928900A5003343059 @default.
• W2090928900 hasAuthorship W2090928900A5039650196 @default.
• W2090928900 hasAuthorship W2090928900A5041519854 @default.
• W2090928900 hasAuthorship W2090928900A5046273039 @default.
• W2090928900 hasAuthorship W2090928900A5050056813 @default.
• W2090928900 hasConcept C112592302 @default.
• W2090928900 hasConcept C12554922 @default.
• W2090928900 hasConcept C130316041 @default.
• W2090928900 hasConcept C147944092 @default.
• W2090928900 hasConcept C148785051 @default.
• W2090928900 hasConcept C169760540 @default.
• W2090928900 hasConcept C170493617 @default.
• W2090928900 hasConcept C185263204 @default.
• W2090928900 hasConcept C185592680 @default.
• W2090928900 hasConcept C197341189 @default.
• W2090928900 hasConcept C200170125 @default.
• W2090928900 hasConcept C2778071365 @default.
• W2090928900 hasConcept C28406088 @default.

• next