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• W2090930310 abstract "Rat liver microsomes were incubated with NADPH, 1,2-[14C]vinyl chloride and poly-adenosine. The latter was reisolated from the incubations and hydrolyzed. The radioactivity, originating from [14C]vinyl chloride, which was irreversibly attached to the poly-adenosine was confined to 1-N6-etheno-adenosine (3β-ribofuranosyl-imidazo[2,1,i] purine). When rats were exposed to 1,2-[14C]vinyl chloride, part of the radioactivity was incorporated into RNA of liver. This radioactive labelling exhibited a first maximum, 14 h, and a second maximum, 72 h after ending the exposure. Analysis of hydrolysate of liver RNA showed that all natural nucleosides of RNA were labelled. Besides, small amounts of radioactivity could be detected which were confined to 1-N6-etheno-adenosine. The experiments support the theory that vinyl chloride metabolites react with adenosine moieties of nucleic acid under formation of 1-N6-etheno-adenosine. Furthermore, the results show that measurement of incorporation of radioactivity into nucleic acids after exposure of animals to radioactive vinyl chloride is not applicable as a means of determining the alkylating potency of vinyl chloride metabolites towards nucleic acids in vivo." @default.
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• W2090930310 date "1977-10-01" @default.
• W2090930310 modified "2023-10-10" @default.
• W2090930310 title "Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1-N6-etheno-adenosine" @default.
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• W2090930310 doi "https://doi.org/10.1016/0300-483x(77)90007-5" @default.
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