FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090930989> ?p ?o ?g. }

• W2090930989 endingPage "1154" @default.
• W2090930989 startingPage "1147" @default.
• W2090930989 abstract "The capacity of mesenchymal stem cells (MSCs) to differentiate into functional osteoblasts is tightly controlled by transcription factors that trigger osteoblast commitment and differentiation. The role of Twist1, a basic helix-loop-helix (bHLH) transcription factor, in osteogenic differentiation of MSCs remains unclear. Here we investigated the role of Twist1 in the osteogenic differentiation program of murine C3H10T1/2 mesenchymal cells. We showed that molecular silencing of Twist1 using short hairpin RNA (shRNA) expression moderately increased C3H10T1/2 cell proliferation and had no effect on cell survival. In contrast, Twist1 silencing enhanced osteoblast gene expression and matrix mineralization in vitro. Biochemical analyses revealed that Twist1 silencing increased the expression of FGFR2 protein level, which was reduced by a mutant Runx2. Consistent with this finding, Twist1 silencing increased ERK1/2 and PI3K signaling. Moreover, molecular or pharmacological inhibition of FGFR2 or of ERK1/2 and PI3K signaling partly abolished the increased osteoblast gene expression induced by Twist1 silencing in C3H10T1/2 cells. These results reveal that Twist1 silencing upregulates osteoblast differentiation of murine mesenchymal cells in part via activation of FGFR2 expression and downstream signaling pathways, which provides novel insights into the molecular signals by which this transcription factor regulates the osteogenic differentiation program in MSCs." @default.
• W2090930989 created "2016-06-24" @default.
• W2090930989 creator A5029582174 @default.
• W2090930989 creator A5032780288 @default.
• W2090930989 creator A5058382284 @default.
• W2090930989 creator A5060545233 @default.
• W2090930989 creator A5061639336 @default.
• W2090930989 date "2010-05-17" @default.
• W2090930989 modified "2023-10-12" @default.
• W2090930989 title "Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: Implication of FGFR2 signaling" @default.
• W2090930989 cites W1483858654 @default.
• W2090930989 cites W1537898230 @default.
• W2090930989 cites W1571287379 @default.
• W2090930989 cites W1965716280 @default.
• W2090930989 cites W1973336625 @default.
• W2090930989 cites W1976329877 @default.
• W2090930989 cites W1983231547 @default.
• W2090930989 cites W1983523339 @default.
• W2090930989 cites W1986997515 @default.
• W2090930989 cites W1990207722 @default.
• W2090930989 cites W1993640536 @default.
• W2090930989 cites W1994910019 @default.
• W2090930989 cites W1996058081 @default.
• W2090930989 cites W1997975993 @default.
• W2090930989 cites W1999306810 @default.
• W2090930989 cites W1999671240 @default.
• W2090930989 cites W2000224896 @default.
• W2090930989 cites W2002345411 @default.
• W2090930989 cites W2006532804 @default.
• W2090930989 cites W2009787091 @default.
• W2090930989 cites W2014786217 @default.
• W2090930989 cites W2021181749 @default.
• W2090930989 cites W2030475521 @default.
• W2090930989 cites W2031297102 @default.
• W2090930989 cites W2036287488 @default.
• W2090930989 cites W2038571131 @default.
• W2090930989 cites W2038675898 @default.
• W2090930989 cites W2041389033 @default.
• W2090930989 cites W2042545863 @default.
• W2090930989 cites W2053425459 @default.
• W2090930989 cites W2055294875 @default.
• W2090930989 cites W2056983875 @default.
• W2090930989 cites W2064129448 @default.
• W2090930989 cites W2070345664 @default.
• W2090930989 cites W2070466054 @default.
• W2090930989 cites W2072506593 @default.
• W2090930989 cites W2075328770 @default.
• W2090930989 cites W2076750266 @default.
• W2090930989 cites W2093339971 @default.
• W2090930989 cites W2102670644 @default.
• W2090930989 cites W2104140742 @default.
• W2090930989 cites W2114511454 @default.
• W2090930989 cites W2114906532 @default.
• W2090930989 cites W2121465001 @default.
• W2090930989 cites W2127114287 @default.
• W2090930989 cites W2132290296 @default.
• W2090930989 cites W2133014215 @default.
• W2090930989 cites W2133228373 @default.
• W2090930989 cites W2145470200 @default.
• W2090930989 cites W2159999899 @default.
• W2090930989 cites W2169709609 @default.
• W2090930989 doi "https://doi.org/10.1002/jcb.22628" @default.
• W2090930989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20564211" @default.
• W2090930989 hasPublicationYear "2010" @default.
• W2090930989 type Work @default.
• W2090930989 sameAs 2090930989 @default.
• W2090930989 citedByCount "44" @default.
• W2090930989 countsByYear W20909309892012 @default.
• W2090930989 countsByYear W20909309892013 @default.
• W2090930989 countsByYear W20909309892014 @default.
• W2090930989 countsByYear W20909309892015 @default.
• W2090930989 countsByYear W20909309892016 @default.
• W2090930989 countsByYear W20909309892017 @default.
• W2090930989 countsByYear W20909309892018 @default.
• W2090930989 countsByYear W20909309892019 @default.
• W2090930989 countsByYear W20909309892020 @default.
• W2090930989 countsByYear W20909309892021 @default.
• W2090930989 countsByYear W20909309892022 @default.
• W2090930989 countsByYear W20909309892023 @default.
• W2090930989 crossrefType "journal-article" @default.
• W2090930989 hasAuthorship W2090930989A5029582174 @default.
• W2090930989 hasAuthorship W2090930989A5032780288 @default.
• W2090930989 hasAuthorship W2090930989A5058382284 @default.
• W2090930989 hasAuthorship W2090930989A5060545233 @default.
• W2090930989 hasAuthorship W2090930989A5061639336 @default.
• W2090930989 hasConcept C104317684 @default.
• W2090930989 hasConcept C119056186 @default.
• W2090930989 hasConcept C148738053 @default.
• W2090930989 hasConcept C173396325 @default.
• W2090930989 hasConcept C185592680 @default.
• W2090930989 hasConcept C190232843 @default.
• W2090930989 hasConcept C198826908 @default.
• W2090930989 hasConcept C202751555 @default.
• W2090930989 hasConcept C2776363554 @default.
• W2090930989 hasConcept C2778260815 @default.
• W2090930989 hasConcept C2778893926 @default.
• W2090930989 hasConcept C29512474 @default.
• W2090930989 hasConcept C54355233 @default.

• next