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- W2090932149 abstract "The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by the expression of a few transcription factors has attracted enormous interest in biomedical research and the field of regenerative medicine. iPSCs nearly identically resemble embryonic stem cells (ESCs) and can give rise to all cell types in the body, and thus have opened new opportunities for personalized regenerative medicine and new ways of modeling human diseases. Although some studies have raised concerns about genomic stability and epigenetic memory in the resulting cells, better understanding and control of the reprogramming process should enable enhanced efficiency and higher fidelity in reprogramming. Therefore, small molecules regulating reprogramming mechanisms are valuable tools to probe the process of reprogramming and harness cell fate transitions for various applications." @default.
- W2090932149 created "2016-06-24" @default.
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- W2090932149 date "2012-12-01" @default.
- W2090932149 modified "2023-09-22" @default.
- W2090932149 title "Cellular reprogramming: a small molecule perspective" @default.
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- W2090932149 doi "https://doi.org/10.1016/j.ceb.2012.08.010" @default.
- W2090932149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3790462" @default.
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