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- W2090932793 abstract "Abstract We report the isolation and characterization of a new mutation in the hybrid phage λimm21. Both genetic and physiological studies demonstrate that this new mutation, N21−1, is similar to N mutations of phage λ. As in the case of the N gene of λ (Niλ), the N21−1 mutation maps immediately to the left of the cI gene and has a pleiotropic effect on the expression of phage functions. Although these studies strongly suggest that phage 21 has an N function, they do not definitely locate the N21−1 mutation within the N21 structural gene. Reported here are studies demonstrating that N21 acts in trans, similar to Nλ, to stimulate the expression of phage functions. N products show an immunity specificity; N21 being only active on phage carrying the immunity region of phage 21, while the nλ is only active on phage carrying the immunity region of λ or phage 434. However, one site of action for Nλ can be rescued from phage 21. We propose that the specificity of an N function is determined by its sites of recognition and that these sites may be different from the sites of N action." @default.
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- W2090932793 title "Gene N regulator function of phage λimm21: Evidence that a site of N action differs from a site of N recognition" @default.
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- W2090932793 doi "https://doi.org/10.1016/0022-2836(73)90519-6" @default.
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