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- W2090935401 abstract "Fixed drug eruption (FDE) is characterized by recurrent welldefined lesions in the same site each time when the responsible drug is taken. A linear distribution pattern of the lesions is extremely rare and has previously been reported as a single case due to antrum sculler injection of cefazolin. We present a 25year-old white female patient with recurrent attacks of discrete, round, violaceous, infiltrated plaques appearing in a striking linear pattern on the right arm following oral co-trimoxazole intake. The clinical and histopathological examination revealed FDE. Oral challenge with co-trimoxazole performed with the 118 of the dose usually taken revealed a positive reaction. Topical provocation with tape-stripping occlusive patch testing with lo%, 20% and 50% concentrations of co-trimoxazole, sulfamethoxazole and trimethoprim in Vaseline remains negative on previous FDE lesions and clinically normal skin. However, a positive reaction was seen on previously involved skin in an open patch test with trimethoprim 50%, co-trimoxazole 20% and 50% in dimethyl sulfoxide. Control tests on clinically normal skin with drug preparations and pure vehicle remained negative. The linear pattern of FDE due to co-trimoxazole and positive openpatch test results with trimethoprim-a less common cause in co-trimoxazole allergy-are the rare and interesting features of our case." @default.
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- W2090935401 title "FC048 Linear fixed drug eruption" @default.
- W2090935401 doi "https://doi.org/10.1016/s0926-9959(97)89367-1" @default.
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