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• W2090936504 abstract "Abstract Purpose To investigate the feasibility of diffusion tensor imaging (DTI) assessment of microscopic fiber tract injury in the corpus callosum (CC) and other normal‐appearing white matter (NAWM) in patients with early multiple sclerosis (MS). Materials and Methods DTI was performed in 12 healthy volunteers and 15 patients who have relatively short disease duration (mean = 2.7 years). Both fractional anisotropy (FA) and mean diffusivity (MD) were obtained in different regions of normal‐appearing CC (NACC) and NAWM in frontal and occipital regions. Results The data showed significantly lower FA ( P < 0.001) and higher MD ( P < 0.04) for NACC regions, but not for frontal and occipital NAWM regions, in patients than in those in healthy volunteers after Bonferroni adjustment. The increase of MD in the entire NACC regions was correlated with the total cerebral lesion volume (r = 0.75, P = 0.001) in patients. Conclusion The water diffusion changes indicate that in the early phase of disease there is a preferential occult injury of CC, which is likely due to the Wallerian degeneration from distant lesions. J. Magn. Reson. Imaging 2004;20:1–7. © 2004 Wiley‐Liss, Inc." @default.
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• W2090936504 date "2004-06-21" @default.
• W2090936504 modified "2023-10-17" @default.
• W2090936504 title "Preferential occult injury of corpus callosum in multiple sclerosis measured by diffusion tensor imaging" @default.
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• W2090936504 doi "https://doi.org/10.1002/jmri.20083" @default.
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