Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090936790> ?p ?o ?g. }
- W2090936790 endingPage "246" @default.
- W2090936790 startingPage "239" @default.
- W2090936790 abstract "Heat shock proteins have been reported to stimulate the immune system via innate receptors. Our study found that the novel immunopotentiator, Eimeria tenella (E. tenella) heat shock protein 70 (HSP70), enhanced protective immunity elicited by E. tenella antigen microneme protein 2 (EtMIC2) against avian coccidiosis. It demonstrated that the expression of TLR2 and TLR4 were strongly upregulated in EtHSP70 and EtMIC2 plus EtHSP70 stimulated chicken embryo fibroblasts (CEF) compared with untreated controls and EtMIC2 alone. In addition, the same treatment induced high levels of interleukin (IL)-12 and interferon (IFN)-γ that are critical cytokines of innate immunity. In vivo experiments involved using broiler chickens subcutaneously immunized with EtMIC2 alone or EtMIC2 plus EtHSP70 at 7 and 14 days post-hatch, which were then orally challenged with live E. tenella at 7 days following secondary immunization. Body weight gains, cecal lesion scores, fecal oocyst shedding, serum antibody responses against MIC2, and intestinal cytokine transcript levels were assessed as measures of protective immunity. Chickens immunized with EtMIC2 plus EtHSP70 showed increased body weight gains, decreased oocyst shedding, increased serum antibody responses, and high levels of IL-12, IFN-γ, and IL-17 compared with the EtMIC2 only or control groups. Moreover, chickens immunized with EtHSP70 alone showed significantly protective effect against E. tenella infection. In summary, this study provides the first evidence of the immunoenhancing activities of EtHSP70 in poultry." @default.
- W2090936790 created "2016-06-24" @default.
- W2090936790 creator A5000557282 @default.
- W2090936790 creator A5005122107 @default.
- W2090936790 creator A5006919426 @default.
- W2090936790 creator A5009271810 @default.
- W2090936790 creator A5018227896 @default.
- W2090936790 creator A5026399465 @default.
- W2090936790 creator A5039591687 @default.
- W2090936790 creator A5044093768 @default.
- W2090936790 creator A5050630149 @default.
- W2090936790 date "2012-09-01" @default.
- W2090936790 modified "2023-10-15" @default.
- W2090936790 title "Eimeria tenella heat shock protein 70 enhances protection of recombinant microneme protein MIC2 subunit antigen vaccination against E. tenella challenge" @default.
- W2090936790 cites W1507924611 @default.
- W2090936790 cites W1515599953 @default.
- W2090936790 cites W1525912444 @default.
- W2090936790 cites W1537128240 @default.
- W2090936790 cites W1975938678 @default.
- W2090936790 cites W1976995229 @default.
- W2090936790 cites W1982293312 @default.
- W2090936790 cites W1992549774 @default.
- W2090936790 cites W1994590893 @default.
- W2090936790 cites W2000181683 @default.
- W2090936790 cites W2004030143 @default.
- W2090936790 cites W2007160781 @default.
- W2090936790 cites W2008908410 @default.
- W2090936790 cites W2012749673 @default.
- W2090936790 cites W2015221103 @default.
- W2090936790 cites W2018240282 @default.
- W2090936790 cites W2022848438 @default.
- W2090936790 cites W2023028120 @default.
- W2090936790 cites W2024490058 @default.
- W2090936790 cites W2024786578 @default.
- W2090936790 cites W2032954442 @default.
- W2090936790 cites W2034524543 @default.
- W2090936790 cites W2035484798 @default.
- W2090936790 cites W2040165635 @default.
- W2090936790 cites W2042459359 @default.
- W2090936790 cites W2051402309 @default.
- W2090936790 cites W2052528673 @default.
- W2090936790 cites W2054626405 @default.
- W2090936790 cites W2070678007 @default.
- W2090936790 cites W2072676033 @default.
- W2090936790 cites W2091536665 @default.
- W2090936790 cites W2093426043 @default.
- W2090936790 cites W2099410504 @default.
- W2090936790 cites W2103047207 @default.
- W2090936790 cites W2107277218 @default.
- W2090936790 cites W2115206025 @default.
- W2090936790 cites W2116736571 @default.
- W2090936790 cites W2124655157 @default.
- W2090936790 cites W2128956445 @default.
- W2090936790 cites W2144053302 @default.
- W2090936790 cites W2144244283 @default.
- W2090936790 cites W2152258983 @default.
- W2090936790 cites W2152994600 @default.
- W2090936790 cites W2161426465 @default.
- W2090936790 cites W2163472843 @default.
- W2090936790 cites W2176944720 @default.
- W2090936790 cites W4318906892 @default.
- W2090936790 doi "https://doi.org/10.1016/j.vetpar.2012.03.025" @default.
- W2090936790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22494937" @default.
- W2090936790 hasPublicationYear "2012" @default.
- W2090936790 type Work @default.
- W2090936790 sameAs 2090936790 @default.
- W2090936790 citedByCount "29" @default.
- W2090936790 countsByYear W20909367902013 @default.
- W2090936790 countsByYear W20909367902014 @default.
- W2090936790 countsByYear W20909367902015 @default.
- W2090936790 countsByYear W20909367902016 @default.
- W2090936790 countsByYear W20909367902017 @default.
- W2090936790 countsByYear W20909367902018 @default.
- W2090936790 countsByYear W20909367902019 @default.
- W2090936790 countsByYear W20909367902020 @default.
- W2090936790 countsByYear W20909367902021 @default.
- W2090936790 countsByYear W20909367902022 @default.
- W2090936790 countsByYear W20909367902023 @default.
- W2090936790 crossrefType "journal-article" @default.
- W2090936790 hasAuthorship W2090936790A5000557282 @default.
- W2090936790 hasAuthorship W2090936790A5005122107 @default.
- W2090936790 hasAuthorship W2090936790A5006919426 @default.
- W2090936790 hasAuthorship W2090936790A5009271810 @default.
- W2090936790 hasAuthorship W2090936790A5018227896 @default.
- W2090936790 hasAuthorship W2090936790A5026399465 @default.
- W2090936790 hasAuthorship W2090936790A5039591687 @default.
- W2090936790 hasAuthorship W2090936790A5044093768 @default.
- W2090936790 hasAuthorship W2090936790A5050630149 @default.
- W2090936790 hasConcept C104317684 @default.
- W2090936790 hasConcept C136449434 @default.
- W2090936790 hasConcept C147483822 @default.
- W2090936790 hasConcept C159047783 @default.
- W2090936790 hasConcept C159654299 @default.
- W2090936790 hasConcept C203014093 @default.
- W2090936790 hasConcept C205260736 @default.
- W2090936790 hasConcept C22070199 @default.
- W2090936790 hasConcept C22889606 @default.
- W2090936790 hasConcept C2776576699 @default.