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• W2090937908 startingPage "155" @default.
• W2090937908 abstract "Neurodegenerative and inflammatory processes are involved separately in major depression (MD) and alcohol-use disorders (AUD). Little is known about the nature of this relationship in the context of comorbid AUD and depression disorders. In this study, we determined brain-derived neurotrophic factor (BDNF) serum levels in patients with AUD and tested whether BDNF levels were related to history of major depression, recent depressive symptoms, AUD severity, and TNF-α and IL-6 levels. Nepalese male AUD inpatients (N = 152) abstinent from alcohol for an average of 34 days were administered structured interviews to assess depression symptoms and pattern and extent of alcohol use, and to generate research diagnoses for AUD and MD. AUD severity was assessed by scores on the Alcohol Use Disorder Identification Test. Serum BDNF and cytokines were measured using ELISA and multiplex technology, respectively. Although serum BDNF levels were unrelated to MD history, patients with recent depressive symptoms (n = 42) had lower (mean ± SD) BDNF serum levels compared to those without (n = 110) (21.6 ± 8.1 ng/mL vs. 26.0 ± 9.6 ng/mL; p = 0.010), and patients with higher AUD severity and binge-drinking patterns had higher mean serum BDNF levels compared to lower AUD severity and non-binging (25.9 ± 9.7 ng/mL vs. 22.1 ± 8.7 ng/mL; p = 0.022 and 25.7 ± 9.3 vs. 21.8 ± 9.7 ng/mL; p = 0.029, respectively). Positive correlations were present between BDNF and TNF-α (r = 0.39, p < 0.001) and IL-6 (r = 0.2, p = 0.027). In particular, TNF-α levels were predictive of BDNF levels after controlling for confounders (B = 0.3 [95% CI = 0.2–0.5], p < 0.001). These findings show that in alcohol-using populations, peripheral BDNF levels are related to severity of AUD as well as presence of depressive symptoms. The significant associations between inflammatory and neurotrophic factors may have implications for neuroadaptive changes during recovery from AUD." @default.
• W2090937908 created "2016-06-24" @default.
• W2090937908 creator A5023746266 @default.
• W2090937908 creator A5026799172 @default.
• W2090937908 creator A5062533289 @default.
• W2090937908 date "2004-03-01" @default.
• W2090937908 modified "2023-10-16" @default.
• W2090937908 title "Somatic treatment of bipolar disorder in children and adolescents" @default.
• W2090937908 cites W104569495 @default.
• W2090937908 cites W129907205 @default.
• W2090937908 cites W14681528 @default.
• W2090937908 cites W1508968103 @default.
• W2090937908 cites W1510762787 @default.
• W2090937908 cites W1532789284 @default.
• W2090937908 cites W1546441681 @default.
• W2090937908 cites W1692435931 @default.
• W2090937908 cites W1787454655 @default.
• W2090937908 cites W1804162708 @default.
• W2090937908 cites W1965756057 @default.
• W2090937908 cites W1967842259 @default.
• W2090937908 cites W1969356187 @default.
• W2090937908 cites W1969746355 @default.
• W2090937908 cites W1969998902 @default.
• W2090937908 cites W1970493513 @default.
• W2090937908 cites W1970892722 @default.
• W2090937908 cites W1972367044 @default.
• W2090937908 cites W1973945801 @default.
• W2090937908 cites W1974637575 @default.
• W2090937908 cites W1975271960 @default.
• W2090937908 cites W1976977809 @default.
• W2090937908 cites W1978904708 @default.
• W2090937908 cites W1979166893 @default.
• W2090937908 cites W1981695853 @default.
• W2090937908 cites W1982911320 @default.
• W2090937908 cites W1983927598 @default.
• W2090937908 cites W1988334035 @default.
• W2090937908 cites W1989313585 @default.
• W2090937908 cites W1989801730 @default.
• W2090937908 cites W1990390137 @default.
• W2090937908 cites W1991061329 @default.
• W2090937908 cites W1991178483 @default.
• W2090937908 cites W1991621530 @default.
• W2090937908 cites W1993009083 @default.
• W2090937908 cites W1994888544 @default.
• W2090937908 cites W1998635520 @default.
• W2090937908 cites W1998686679 @default.
• W2090937908 cites W1998982477 @default.
• W2090937908 cites W2002989575 @default.
• W2090937908 cites W2005855713 @default.
• W2090937908 cites W2006690415 @default.
• W2090937908 cites W2008641440 @default.
• W2090937908 cites W2008808382 @default.
• W2090937908 cites W2011347417 @default.
• W2090937908 cites W2011348789 @default.
• W2090937908 cites W2014027409 @default.
• W2090937908 cites W2019134598 @default.
• W2090937908 cites W2019879674 @default.
• W2090937908 cites W2021438761 @default.
• W2090937908 cites W2021987865 @default.
• W2090937908 cites W2022501784 @default.
• W2090937908 cites W2023634194 @default.
• W2090937908 cites W2025218882 @default.
• W2090937908 cites W2025885344 @default.
• W2090937908 cites W2025944570 @default.
• W2090937908 cites W2026059580 @default.
• W2090937908 cites W2030636384 @default.
• W2090937908 cites W2034419317 @default.
• W2090937908 cites W2034825582 @default.
• W2090937908 cites W2034874958 @default.
• W2090937908 cites W2037404994 @default.
• W2090937908 cites W2037648085 @default.
• W2090937908 cites W2038369976 @default.
• W2090937908 cites W2040676799 @default.
• W2090937908 cites W2040961829 @default.
• W2090937908 cites W2042049452 @default.
• W2090937908 cites W2042514504 @default.
• W2090937908 cites W2046534027 @default.
• W2090937908 cites W2046743792 @default.
• W2090937908 cites W2051539350 @default.
• W2090937908 cites W2054572750 @default.
• W2090937908 cites W2054776920 @default.
• W2090937908 cites W2055849119 @default.
• W2090937908 cites W2057336559 @default.
• W2090937908 cites W2057355569 @default.
• W2090937908 cites W2059747380 @default.
• W2090937908 cites W2060403509 @default.
• W2090937908 cites W2060802427 @default.
• W2090937908 cites W2065399671 @default.
• W2090937908 cites W2067833727 @default.
• W2090937908 cites W2069620570 @default.
• W2090937908 cites W2072149409 @default.
• W2090937908 cites W2073272416 @default.
• W2090937908 cites W2073556539 @default.
• W2090937908 cites W2076104431 @default.
• W2090937908 cites W2078677818 @default.
• W2090937908 cites W2078863929 @default.
• W2090937908 cites W2080643792 @default.
• W2090937908 cites W2081819435 @default.

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