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• W2090939224 abstract "<h3>Hypothesis</h3> The reported morbidity and mortality associated with esophagectomy for high-grade dysplasia (HGD) and intramucosal cancer (IMC) have led asymptomatic patients to consider less invasive and possibly less effective treatments. This study provides a critical assessment of outcomes and health-related quality of life (HRQL) after esophagectomy for HGD and IMC. <h3>Design</h3> Cohort analytic study. <h3>Setting</h3> Section of thoracic surgery at a tertiary referral center. <h3>Patients</h3> All patients who presented between May 1991 and February 2003 with a biopsy-proven diagnosis of Barrett esophagus with HGD or IMC were assessed. <h3>Main Outcome Measures</h3> Prospective analysis of postoperative morbidity, mortality, HRQL, and gastrointestinal symptoms. <h3>Results</h3> Follow-up was complete in 36 patients. Mean follow-up was 4.9 years (range, 0.5-12.0 years). The incidence of postoperative invasive cancer was 39%, with stages ranging from I to IIB. There were 4 major complications (11%) and no operative mortality. Twenty-eight patients were alive, with a cancer-free survival of 85%. The HRQL outcomes (Medical Outcomes Study 36-Item Short-Form Health Survey) were comparable with those of age- and sex-matched controls. Significant differences in postesophagectomy gastrointestinal symptoms were seen with a decreased incidence of heartburn (<i>P</i>≤.001) and increased requirement for a slower speed of eating. Twenty-two (79%) of the 28 patients described their current eating pattern as “normal or insignificantly impacted.” <h3>Conclusions</h3> Esophagectomy for HGD and IMC can be accomplished with low morbidity and mortality. Furthermore, most patients are able to resume a normal eating pattern, and postoperative HRQL can be equivalent to that of the general population." @default.
• W2090939224 created "2016-06-24" @default.
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• W2090939224 date "2006-06-01" @default.
• W2090939224 modified "2023-10-15" @default.
• W2090939224 title "Outcomes and Health-Related Quality of Life After Esophagectomy for High-Grade Dysplasia and Intramucosal Cancer" @default.
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• W2090939224 doi "https://doi.org/10.1001/archsurg.141.6.545" @default.
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