FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090939777> ?p ?o ?g. }

• W2090939777 endingPage "6105" @default.
• W2090939777 startingPage "6097" @default.
• W2090939777 abstract "Ribosomal S6 kinase 2 (RSK2) is a serine/threonine kinase that plays a role in human cancer and Coffin–Lowry syndrome and is comprised of two nonidentical kinase domains, each domain with its own ATP-binding site. RSK2 can be inactivated by different types of small organic molecules. Potent RSK2 inhibitors include the two classic bisindole maleimide PKC inhibitors, Ro31-8220 and GF109203X, and the natural product SL0101 that was shown to bind specifically to the ATP pocket of the N-terminal domain (NTD). In this paper, we present an atomic model of the RSK2 NTD (residues 68–323), which was built to simultaneously bind the distinctive molecular scaffolds of SL0101, Ro31-8220, and GF109203X. The RSK2 NTD model was used to identify two novel RSK2 inhibitors from the National Cancer Institute open chemical repository and to develop a preliminary structure-based pharmacophore model." @default.
• W2090939777 created "2016-06-24" @default.
• W2090939777 creator A5001233790 @default.
• W2090939777 creator A5006249781 @default.
• W2090939777 creator A5017489905 @default.
• W2090939777 creator A5022584810 @default.
• W2090939777 creator A5023778256 @default.
• W2090939777 creator A5034427633 @default.
• W2090939777 creator A5050766337 @default.
• W2090939777 creator A5084816440 @default.
• W2090939777 date "2006-09-01" @default.
• W2090939777 modified "2023-10-18" @default.
• W2090939777 title "Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore" @default.
• W2090939777 cites W1523620726 @default.
• W2090939777 cites W1542374364 @default.
• W2090939777 cites W1942192923 @default.
• W2090939777 cites W1976396917 @default.
• W2090939777 cites W2001138775 @default.
• W2090939777 cites W2004583463 @default.
• W2090939777 cites W2012051875 @default.
• W2090939777 cites W2014394165 @default.
• W2090939777 cites W2016932835 @default.
• W2090939777 cites W2018221682 @default.
• W2090939777 cites W2029169661 @default.
• W2090939777 cites W2033630329 @default.
• W2090939777 cites W2034480012 @default.
• W2090939777 cites W2063897912 @default.
• W2090939777 cites W2077341537 @default.
• W2090939777 cites W2088692628 @default.
• W2090939777 cites W2113440293 @default.
• W2090939777 cites W2114869204 @default.
• W2090939777 cites W2123759975 @default.
• W2090939777 cites W2157761330 @default.
• W2090939777 cites W2162658917 @default.
• W2090939777 cites W4235138696 @default.
• W2090939777 doi "https://doi.org/10.1016/j.bmc.2006.05.001" @default.
• W2090939777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16723234" @default.
• W2090939777 hasPublicationYear "2006" @default.
• W2090939777 type Work @default.
• W2090939777 sameAs 2090939777 @default.
• W2090939777 citedByCount "42" @default.
• W2090939777 countsByYear W20909397772012 @default.
• W2090939777 countsByYear W20909397772013 @default.
• W2090939777 countsByYear W20909397772014 @default.
• W2090939777 countsByYear W20909397772015 @default.
• W2090939777 countsByYear W20909397772016 @default.
• W2090939777 countsByYear W20909397772017 @default.
• W2090939777 countsByYear W20909397772018 @default.
• W2090939777 countsByYear W20909397772021 @default.
• W2090939777 countsByYear W20909397772022 @default.
• W2090939777 countsByYear W20909397772023 @default.
• W2090939777 crossrefType "journal-article" @default.
• W2090939777 hasAuthorship W2090939777A5001233790 @default.
• W2090939777 hasAuthorship W2090939777A5006249781 @default.
• W2090939777 hasAuthorship W2090939777A5017489905 @default.
• W2090939777 hasAuthorship W2090939777A5022584810 @default.
• W2090939777 hasAuthorship W2090939777A5023778256 @default.
• W2090939777 hasAuthorship W2090939777A5034427633 @default.
• W2090939777 hasAuthorship W2090939777A5050766337 @default.
• W2090939777 hasAuthorship W2090939777A5084816440 @default.
• W2090939777 hasConcept C104317684 @default.
• W2090939777 hasConcept C11960822 @default.
• W2090939777 hasConcept C143065580 @default.
• W2090939777 hasConcept C169627665 @default.
• W2090939777 hasConcept C181199279 @default.
• W2090939777 hasConcept C184235292 @default.
• W2090939777 hasConcept C185592680 @default.
• W2090939777 hasConcept C195794163 @default.
• W2090939777 hasConcept C2775880066 @default.
• W2090939777 hasConcept C2776414213 @default.
• W2090939777 hasConcept C2779396153 @default.
• W2090939777 hasConcept C32619005 @default.
• W2090939777 hasConcept C55493867 @default.
• W2090939777 hasConcept C56173144 @default.
• W2090939777 hasConcept C71240020 @default.
• W2090939777 hasConceptScore W2090939777C104317684 @default.
• W2090939777 hasConceptScore W2090939777C11960822 @default.
• W2090939777 hasConceptScore W2090939777C143065580 @default.
• W2090939777 hasConceptScore W2090939777C169627665 @default.
• W2090939777 hasConceptScore W2090939777C181199279 @default.
• W2090939777 hasConceptScore W2090939777C184235292 @default.
• W2090939777 hasConceptScore W2090939777C185592680 @default.
• W2090939777 hasConceptScore W2090939777C195794163 @default.
• W2090939777 hasConceptScore W2090939777C2775880066 @default.
• W2090939777 hasConceptScore W2090939777C2776414213 @default.
• W2090939777 hasConceptScore W2090939777C2779396153 @default.
• W2090939777 hasConceptScore W2090939777C32619005 @default.
• W2090939777 hasConceptScore W2090939777C55493867 @default.
• W2090939777 hasConceptScore W2090939777C56173144 @default.
• W2090939777 hasConceptScore W2090939777C71240020 @default.
• W2090939777 hasIssue "17" @default.
• W2090939777 hasLocation W20909397771 @default.
• W2090939777 hasLocation W20909397772 @default.
• W2090939777 hasOpenAccess W2090939777 @default.
• W2090939777 hasPrimaryLocation W20909397771 @default.
• W2090939777 hasRelatedWork W1965531819 @default.
• W2090939777 hasRelatedWork W2037437285 @default.
• W2090939777 hasRelatedWork W2038458614 @default.

• next