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• W2090942708 abstract "To review the literature on the toxicity of Callilepis laureola, and to assess the cytotoxicity of C. laureola in human hepatoblastoma Hep G2 cells in vitro.Cells were incubated for up to 48 h in the presence of increasing concentrations of an aqueous extract of C. laureola (0.3-13.3 mg/mL). Cytotoxicity was quantitated spectrophotometrically by the metabolism of the tetrazolium dye MTT. Cytoviability of the control cells was considered to be 100%.C. laureola produced cytotoxicity in a concentration-dependent manner. Cytotoxicity was significant at all concentrations tested (0.3-2.5 mg/mL, p < 0.05 vs. controls and 3.3-13.3 mg/mL, p < 0.0001 vs. controls). After 6 h, 100% toxicity was observed at a concentration of 6.7 mg/mL.C. laureola causes significant cytotoxicity in Hep G2 cells in vitro. These findings are in accordance with the observed hepatotoxicity in clinical cases of C. laureola poisoning." @default.
• W2090942708 created "2016-06-24" @default.
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• W2090942708 date "2001-05-01" @default.
• W2090942708 modified "2023-09-30" @default.
• W2090942708 title "The toxicity of Callilepis laureola, a South African traditional herbal medicine" @default.
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• W2090942708 doi "https://doi.org/10.1016/s0009-9120(01)00219-3" @default.
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• W2090942708 hasPublicationYear "2001" @default.
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