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• W2090947255 abstract "Determinar la variabilidad entre el peso estimado (PE) y el peso real (PR) de los pacientes a los que se administra alteplasa como tratamiento del ictus isquémico agudo (IIA), según las fuentes de las que se obtiene (paciente, familia y personal sanitario), y su repercusión sobre la dosis de alteplasa administrada. Estudio prospectivo de pacientes con IIA tratados con alteplasa en nuestro hospital de mayo de 2010 a mayo de 2011. La dosis de alteplasa se calculó en función del PE. Se determinó el PR pesando a los pacientes en las 24 horas siguientes a la infusión de la medicación. Se incluyó a 72 pacientes. Globalmente, se sobreestimó el peso una media de 2,49 kg. El personal sanitario sobrevaloró el peso (estimación > 10% del PR) en el 45% de casos; los familiares en el 14%, mientras que ningún paciente sobreestimó su peso (p = 0,005). El paciente se aproximó más a su PR; sin embargo, fue la fuente menos empleada. La dosis real administrada (DRA) media de alteplasa fue de 0,932 mg/kg. El cálculo de dosis de alteplasa a partir del PE del paciente conlleva una variabilidad de la DRA, que podría afectar a la eficacia y la seguridad del tratamiento. Debemos considerar siempre que sea posible la información proporcionada por el paciente sobre su peso. Es necesario buscar una fórmula que permita obtener el PR del paciente, evitando recurrir a la estimación visual del peso. Our aim is to evaluate the variability between estimated patient weight (EPW) and actual patient weight (APW), depending on the source of weight estimation (patient, family or hospital staff) and the impact on the “true dose” (TD) of iv alteplase administered. Prospective study of patients with acute ischemic stroke treated consecutively with iv tPA in our institution from May 2010 to May 2011. Alteplase dosing was calculated according to EPW. APW was determined in the 24 hours following iv alteplase treatment. A total of 72 patients were included. Globally, patient's weight was overestimated: mean=2.49 Kg. Hospital staff overestimated the patient's weight (estimation>10% of APW) in 45% of cases; the family overestimated in 14% of cases, while no patients overestimated their own weight (p=.005). The patients were the most accurate source to establish their actual weight, but also the least used source. The average TD of alteplase was 0.932 mg/Kg. Dose calculation of alteplase according to EPW leads to variation of the TD, which may affect the safety and effectiveness of the treatment. Whenever possible, the patients’ estimation of their own weight should be taken into consideration. A method to obtain the APW is needed, avoiding the use of visual weight estimation." @default.
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• W2090947255 date "2012-01-01" @default.
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• W2090947255 title "Una cuestión de peso: variabilidad en la estimación del peso del paciente para el cálculo de la dosis de alteplasa IV en el tratamiento del ictus isquémico agudo" @default.
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• W2090947255 doi "https://doi.org/10.1016/s2013-5246(12)70022-3" @default.
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