FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090948114> ?p ?o ?g. }

• W2090948114 endingPage "1113" @default.
• W2090948114 startingPage "1107" @default.
• W2090948114 abstract "The lifetimes for exchange of the imino protons in the dodecanucleotide d(C-G-C-G-A-A-T-T-C-G-C-G) upon binding of netropsin and/or actinomycin have been measured by proton nuclear magnetic resonance experiments. At high temperature these lifetimes were found to measure the lifetimes for opening of the base pairs in the double helix. Comparison of the opening rates in the dodecamer with those in the complex with netropsin (which binds at the -A-A-T-T- sequence) shows that there is not only a large kinetic stabilization of the A . T base pairs at the binding site but also a significant stabilization of the G . C base pairs adjacent to the netropsin binding site. For the complex with actinomycin, which intercalates at the G-C sites in the double strand, the lifetimes of the base pairs at the binding site increase upon binding of actinomycin, and the A . T base pairs in the central core are slightly kinetically destabilized by the actinomycin binding. The activation energies for exchange of the imino protons were also measured in the complexes and indicate that the mechanism for exchange of the imino protons is individual base-pair opening, where one base pair opens independently of the others. The effects of drug binding on the dynamics of individual base pairs in a double-stranded helix are discussed." @default.
• W2090948114 created "2016-06-24" @default.
• W2090948114 creator A5008236945 @default.
• W2090948114 creator A5069717228 @default.
• W2090948114 creator A5077706769 @default.
• W2090948114 creator A5080930062 @default.
• W2090948114 date "1983-03-01" @default.
• W2090948114 modified "2023-09-26" @default.
• W2090948114 title "Kinetics for exchange of the imino protons of the d(C-G-C-G-A-A-T-T-C-G-C-G) double helix in complexes with the antibiotics netropsin and/or actinomycin" @default.
• W2090948114 cites W1517723618 @default.
• W2090948114 cites W1518002808 @default.
• W2090948114 cites W1968642113 @default.
• W2090948114 cites W1979720868 @default.
• W2090948114 cites W1997208628 @default.
• W2090948114 cites W2025842644 @default.
• W2090948114 cites W2036847094 @default.
• W2090948114 cites W2042838120 @default.
• W2090948114 cites W2049115187 @default.
• W2090948114 cites W2052461110 @default.
• W2090948114 cites W2069849994 @default.
• W2090948114 cites W2080648180 @default.
• W2090948114 cites W2082127573 @default.
• W2090948114 cites W2087794185 @default.
• W2090948114 cites W2094487655 @default.
• W2090948114 cites W2165855161 @default.
• W2090948114 cites W5140127 @default.
• W2090948114 doi "https://doi.org/10.1021/bi00274a018" @default.
• W2090948114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6301539" @default.
• W2090948114 hasPublicationYear "1983" @default.
• W2090948114 type Work @default.
• W2090948114 sameAs 2090948114 @default.
• W2090948114 citedByCount "47" @default.
• W2090948114 crossrefType "journal-article" @default.
• W2090948114 hasAuthorship W2090948114A5008236945 @default.
• W2090948114 hasAuthorship W2090948114A5069717228 @default.
• W2090948114 hasAuthorship W2090948114A5077706769 @default.
• W2090948114 hasAuthorship W2090948114A5080930062 @default.
• W2090948114 hasBestOaLocation W20909481142 @default.
• W2090948114 hasConcept C107824862 @default.
• W2090948114 hasConcept C121332964 @default.
• W2090948114 hasConcept C134306372 @default.
• W2090948114 hasConcept C148898269 @default.
• W2090948114 hasConcept C184779094 @default.
• W2090948114 hasConcept C185581394 @default.
• W2090948114 hasConcept C185592680 @default.
• W2090948114 hasConcept C18903297 @default.
• W2090948114 hasConcept C2778530040 @default.
• W2090948114 hasConcept C2779965526 @default.
• W2090948114 hasConcept C2781063032 @default.
• W2090948114 hasConcept C3019303373 @default.
• W2090948114 hasConcept C33923547 @default.
• W2090948114 hasConcept C35271833 @default.
• W2090948114 hasConcept C42058472 @default.
• W2090948114 hasConcept C552990157 @default.
• W2090948114 hasConcept C55493867 @default.
• W2090948114 hasConcept C62520636 @default.
• W2090948114 hasConcept C71240020 @default.
• W2090948114 hasConcept C8010536 @default.
• W2090948114 hasConcept C86803240 @default.
• W2090948114 hasConcept C93282013 @default.
• W2090948114 hasConceptScore W2090948114C107824862 @default.
• W2090948114 hasConceptScore W2090948114C121332964 @default.
• W2090948114 hasConceptScore W2090948114C134306372 @default.
• W2090948114 hasConceptScore W2090948114C148898269 @default.
• W2090948114 hasConceptScore W2090948114C184779094 @default.
• W2090948114 hasConceptScore W2090948114C185581394 @default.
• W2090948114 hasConceptScore W2090948114C185592680 @default.
• W2090948114 hasConceptScore W2090948114C18903297 @default.
• W2090948114 hasConceptScore W2090948114C2778530040 @default.
• W2090948114 hasConceptScore W2090948114C2779965526 @default.
• W2090948114 hasConceptScore W2090948114C2781063032 @default.
• W2090948114 hasConceptScore W2090948114C3019303373 @default.
• W2090948114 hasConceptScore W2090948114C33923547 @default.
• W2090948114 hasConceptScore W2090948114C35271833 @default.
• W2090948114 hasConceptScore W2090948114C42058472 @default.
• W2090948114 hasConceptScore W2090948114C552990157 @default.
• W2090948114 hasConceptScore W2090948114C55493867 @default.
• W2090948114 hasConceptScore W2090948114C62520636 @default.
• W2090948114 hasConceptScore W2090948114C71240020 @default.
• W2090948114 hasConceptScore W2090948114C8010536 @default.
• W2090948114 hasConceptScore W2090948114C86803240 @default.
• W2090948114 hasConceptScore W2090948114C93282013 @default.
• W2090948114 hasIssue "5" @default.
• W2090948114 hasLocation W20909481141 @default.
• W2090948114 hasLocation W20909481142 @default.
• W2090948114 hasLocation W20909481143 @default.
• W2090948114 hasLocation W20909481144 @default.
• W2090948114 hasOpenAccess W2090948114 @default.
• W2090948114 hasPrimaryLocation W20909481141 @default.
• W2090948114 hasRelatedWork W1975079800 @default.
• W2090948114 hasRelatedWork W2002669072 @default.
• W2090948114 hasRelatedWork W2011692666 @default.
• W2090948114 hasRelatedWork W2018996043 @default.
• W2090948114 hasRelatedWork W2051331961 @default.
• W2090948114 hasRelatedWork W2075854877 @default.
• W2090948114 hasRelatedWork W2117152823 @default.
• W2090948114 hasRelatedWork W2165090578 @default.
• W2090948114 hasRelatedWork W2411931512 @default.

• next