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• W2090949169 abstract "In the present study, we clarified that transforming growth factor beta (TGF-beta) induces cellular senescence in human normal diploid cells, TIG-1, and identified protein kinase Cs (PKCs) as downstream mediators of TGF-beta-induced cellular senescence. Among PKCs, we showed that PKC-delta induced cellular senescence in TIG-1 cells and was activated in replicatively and prematurely senescent TIG-1 cells. The causative role of PKC-delta in cellular senescence programs was demonstrated using a kinase negative PKC-delta and small interfering RNA against PKC-delta. Furthermore, PKC-delta was shown to function in human telomerase reverse transcriptase (hTERT) gene repression. These results indicate that PKC-delta plays a key role in cellular senescence programs, and suggest that the induction of senescence and hTERT repression are coordinately regulated by PKC-delta." @default.
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• W2090949169 date "2009-03-11" @default.
• W2090949169 modified "2023-09-26" @default.
• W2090949169 title "Protein Kinase C Plays a Key Role in Cellular Senescence Programs of Human Normal Diploid Cells" @default.
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• W2090949169 doi "https://doi.org/10.1093/jb/mvp046" @default.
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