FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090954313> ?p ?o ?g. }

• W2090954313 endingPage "8168" @default.
• W2090954313 startingPage "8163" @default.
• W2090954313 abstract "The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize to a target mRNA. Endogenous RNase P cleaves the mRNA in the complex, making it inactive. EGSs participate in this biochemical reaction as the data presented here show. They promote mRNA cleavage at the expected site and sometimes at other secondary sites. Higher-order structure must affect these reactions if the cleavage does not occur at the defined site, which has been determined by techniques based on their ability to find sites that are accessible to the EGS oligonucleotides. Sites defined by a random EGS technique occur as expected. Oligonucleotides made up primarily of defined or random nucleotides are extremely useful in inhibiting expression of the gyrA and rnpA genes from several different bacteria or the cat gene that determines resistance to chloramphenicol in Escherichia coli . An EGS made up of a peptide-phosphorodiamidate morpholino oligonucleotide (PPMO) does not cleave at the same site as an unmodified RNA EGS for reasons that are only partly understood. However, PPMO-EGSs are useful in inhibiting the expression of targeted genes from Gram-negative and Gram-positive organisms during ordinary growth in broth and may provide a basis for broad-spectrum antibiotics." @default.
• W2090954313 created "2016-06-24" @default.
• W2090954313 creator A5003873129 @default.
• W2090954313 creator A5015279066 @default.
• W2090954313 creator A5040816612 @default.
• W2090954313 creator A5061702878 @default.
• W2090954313 creator A5068469239 @default.
• W2090954313 creator A5071876374 @default.
• W2090954313 creator A5080839836 @default.
• W2090954313 creator A5086360290 @default.
• W2090954313 date "2009-05-19" @default.
• W2090954313 modified "2023-09-23" @default.
• W2090954313 title "Inactivation of expression of several genes in a variety of bacterial species by EGS technology" @default.
• W2090954313 cites W1514259902 @default.
• W2090954313 cites W1554077370 @default.
• W2090954313 cites W1975540042 @default.
• W2090954313 cites W2000238072 @default.
• W2090954313 cites W2011879414 @default.
• W2090954313 cites W2013889630 @default.
• W2090954313 cites W2015301707 @default.
• W2090954313 cites W2069931361 @default.
• W2090954313 cites W2080036688 @default.
• W2090954313 cites W2092043019 @default.
• W2090954313 cites W2112272980 @default.
• W2090954313 cites W2136621397 @default.
• W2090954313 cites W2141157874 @default.
• W2090954313 cites W2151828760 @default.
• W2090954313 cites W2154850940 @default.
• W2090954313 cites W2155095415 @default.
• W2090954313 cites W2165784087 @default.
• W2090954313 cites W2416893369 @default.
• W2090954313 cites W4231492812 @default.
• W2090954313 doi "https://doi.org/10.1073/pnas.0903491106" @default.
• W2090954313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2688897" @default.
• W2090954313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19416872" @default.
• W2090954313 hasPublicationYear "2009" @default.
• W2090954313 type Work @default.
• W2090954313 sameAs 2090954313 @default.
• W2090954313 citedByCount "41" @default.
• W2090954313 countsByYear W20909543132012 @default.
• W2090954313 countsByYear W20909543132013 @default.
• W2090954313 countsByYear W20909543132014 @default.
• W2090954313 countsByYear W20909543132015 @default.
• W2090954313 countsByYear W20909543132016 @default.
• W2090954313 countsByYear W20909543132017 @default.
• W2090954313 countsByYear W20909543132018 @default.
• W2090954313 countsByYear W20909543132019 @default.
• W2090954313 countsByYear W20909543132020 @default.
• W2090954313 countsByYear W20909543132021 @default.
• W2090954313 countsByYear W20909543132023 @default.
• W2090954313 crossrefType "journal-article" @default.
• W2090954313 hasAuthorship W2090954313A5003873129 @default.
• W2090954313 hasAuthorship W2090954313A5015279066 @default.
• W2090954313 hasAuthorship W2090954313A5040816612 @default.
• W2090954313 hasAuthorship W2090954313A5061702878 @default.
• W2090954313 hasAuthorship W2090954313A5068469239 @default.
• W2090954313 hasAuthorship W2090954313A5071876374 @default.
• W2090954313 hasAuthorship W2090954313A5080839836 @default.
• W2090954313 hasAuthorship W2090954313A5086360290 @default.
• W2090954313 hasBestOaLocation W20909543131 @default.
• W2090954313 hasConcept C104317684 @default.
• W2090954313 hasConcept C105580179 @default.
• W2090954313 hasConcept C10879258 @default.
• W2090954313 hasConcept C129312508 @default.
• W2090954313 hasConcept C150194340 @default.
• W2090954313 hasConcept C151730666 @default.
• W2090954313 hasConcept C175156509 @default.
• W2090954313 hasConcept C185592680 @default.
• W2090954313 hasConcept C43369102 @default.
• W2090954313 hasConcept C523546767 @default.
• W2090954313 hasConcept C54355233 @default.
• W2090954313 hasConcept C547475151 @default.
• W2090954313 hasConcept C55493867 @default.
• W2090954313 hasConcept C67705224 @default.
• W2090954313 hasConcept C86803240 @default.
• W2090954313 hasConceptScore W2090954313C104317684 @default.
• W2090954313 hasConceptScore W2090954313C105580179 @default.
• W2090954313 hasConceptScore W2090954313C10879258 @default.
• W2090954313 hasConceptScore W2090954313C129312508 @default.
• W2090954313 hasConceptScore W2090954313C150194340 @default.
• W2090954313 hasConceptScore W2090954313C151730666 @default.
• W2090954313 hasConceptScore W2090954313C175156509 @default.
• W2090954313 hasConceptScore W2090954313C185592680 @default.
• W2090954313 hasConceptScore W2090954313C43369102 @default.
• W2090954313 hasConceptScore W2090954313C523546767 @default.
• W2090954313 hasConceptScore W2090954313C54355233 @default.
• W2090954313 hasConceptScore W2090954313C547475151 @default.
• W2090954313 hasConceptScore W2090954313C55493867 @default.
• W2090954313 hasConceptScore W2090954313C67705224 @default.
• W2090954313 hasConceptScore W2090954313C86803240 @default.
• W2090954313 hasIssue "20" @default.
• W2090954313 hasLocation W20909543131 @default.
• W2090954313 hasLocation W20909543132 @default.
• W2090954313 hasLocation W20909543133 @default.
• W2090954313 hasLocation W20909543134 @default.
• W2090954313 hasOpenAccess W2090954313 @default.
• W2090954313 hasPrimaryLocation W20909543131 @default.
• W2090954313 hasRelatedWork W1626305077 @default.

• next