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- W2090955387 abstract "Abstract To determine whether alterations of T and B lymphocytes occur in Sjogren syndrome (SS) patients, we utilized monoclonal antibodies to characterize 14 individuals with primary SS. The results were compared with 10 spontaneous and 3 drug-induced active systemic lupus erythematosis (SLE) patients, 10 inactive SLE patients, and 35 normal controls. In 10 of 14 cases of SS and all cases of active SLE, the percentages of T cells (T3) were decreased. Ten of fourteen patients with SS had a selective decrease in suppressor (T8) cells and an increased T4/T8 ratio. These findings were not specific for SS since 9 of 10 patients with spontaneous active SLE and 3 drug-induced SLE had similar abnormalities. Moreover, 4 of 14 patients with SS had a decreased T4/T8 ratio. Lastly, there was a major increase in the number of circulating B lymphocytes (B1), and in spontaneous IgG synthesis by these B cells in patients with non-drug-induced active SLE. These findings suggest that the nature of immunoregulatory T-cell-subset abnormalities in SS is heterogenous and that the B-cell abnormalities observed in SLE may in part account for the clinical differences between the two diseases." @default.
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- W2090955387 date "1982-02-01" @default.
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- W2090955387 title "Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus" @default.
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- W2090955387 doi "https://doi.org/10.1016/0090-1229(82)90043-5" @default.
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