Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090957027> ?p ?o ?g. }
- W2090957027 endingPage "3470" @default.
- W2090957027 startingPage "3463" @default.
- W2090957027 abstract "Chemokine receptor 4 and stromal-cell-derived factor 1 have been found to be related to the initiation of neuroinflammation in ischemic brain. Herein, we aimed to monitor the changes of neuorinflammation after AMD3100 treatment using a translocator protein (TSPO) specific PET tracer in a mouse model of stroke. The transient MCAO model was established with Balb/C mice. The success of the model was confirmed by magnetic resonance imaging and FDG PET. The treatment started the same day after surgery via daily intraperitoneal injection of 1 mg of AMD3100/kg for three consecutive days. [(18)F]DPA-714 was used as the TSPO imaging tracer. In vivo PET was performed at different time points after surgery in both control and treated mice. Ex vivo histological and immunofluorescence staining of brain slices was performed to confirm the lesion site and inflammatory cell activation. The TSPO level was also evaluated using Western blotting. Longitudinal PET scans revealed that the level of [(18)F]DPA-714 uptake was significantly increased in the ischemic brain area with a peak accumulation at around day 10 after surgery, and the level of uptake remained high until day 16. The in vivo PET data were consistent with those from ex vivo immunofluorescence staining. After AMD3100 treatment, the signal intensity was significantly decreased compared with that of normal saline-treated control group. In conclusion, TSPO-targeted PET imaging using [(18)F]DPA-714 can be used to monitor inflammatory response after stroke and provide a useful method for evaluating the efficacy of anti-inflammation treatment." @default.
- W2090957027 created "2016-06-24" @default.
- W2090957027 creator A5005900235 @default.
- W2090957027 creator A5018249388 @default.
- W2090957027 creator A5056053058 @default.
- W2090957027 creator A5061153948 @default.
- W2090957027 creator A5079594267 @default.
- W2090957027 creator A5083487683 @default.
- W2090957027 creator A5088055918 @default.
- W2090957027 creator A5089833045 @default.
- W2090957027 date "2014-09-04" @default.
- W2090957027 modified "2023-10-14" @default.
- W2090957027 title "[<sup>18</sup>F]DPA-714 PET Imaging of AMD3100 Treatment in a Mouse Model of Stroke" @default.
- W2090957027 cites W109974507 @default.
- W2090957027 cites W1543220690 @default.
- W2090957027 cites W1964777884 @default.
- W2090957027 cites W1964953009 @default.
- W2090957027 cites W1974955493 @default.
- W2090957027 cites W1982808247 @default.
- W2090957027 cites W1987265891 @default.
- W2090957027 cites W2002516266 @default.
- W2090957027 cites W2004349171 @default.
- W2090957027 cites W2015130097 @default.
- W2090957027 cites W2019172625 @default.
- W2090957027 cites W2019268848 @default.
- W2090957027 cites W2024579431 @default.
- W2090957027 cites W2025587438 @default.
- W2090957027 cites W2026851205 @default.
- W2090957027 cites W2031648971 @default.
- W2090957027 cites W2033426336 @default.
- W2090957027 cites W2038473458 @default.
- W2090957027 cites W2043441080 @default.
- W2090957027 cites W2047850885 @default.
- W2090957027 cites W2058478476 @default.
- W2090957027 cites W2061461261 @default.
- W2090957027 cites W2072171721 @default.
- W2090957027 cites W2075286738 @default.
- W2090957027 cites W2077846964 @default.
- W2090957027 cites W2086542226 @default.
- W2090957027 cites W2095272243 @default.
- W2090957027 cites W2095544898 @default.
- W2090957027 cites W2111354263 @default.
- W2090957027 cites W2113986402 @default.
- W2090957027 cites W2116750341 @default.
- W2090957027 cites W2118641334 @default.
- W2090957027 cites W2122828560 @default.
- W2090957027 cites W2126680127 @default.
- W2090957027 cites W2145728390 @default.
- W2090957027 cites W2154702871 @default.
- W2090957027 cites W2166867187 @default.
- W2090957027 cites W2167585586 @default.
- W2090957027 cites W2168960901 @default.
- W2090957027 cites W2916269539 @default.
- W2090957027 doi "https://doi.org/10.1021/mp500234d" @default.
- W2090957027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4186675" @default.
- W2090957027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25157648" @default.
- W2090957027 hasPublicationYear "2014" @default.
- W2090957027 type Work @default.
- W2090957027 sameAs 2090957027 @default.
- W2090957027 citedByCount "20" @default.
- W2090957027 countsByYear W20909570272015 @default.
- W2090957027 countsByYear W20909570272016 @default.
- W2090957027 countsByYear W20909570272017 @default.
- W2090957027 countsByYear W20909570272018 @default.
- W2090957027 countsByYear W20909570272019 @default.
- W2090957027 countsByYear W20909570272020 @default.
- W2090957027 countsByYear W20909570272021 @default.
- W2090957027 countsByYear W20909570272022 @default.
- W2090957027 countsByYear W20909570272023 @default.
- W2090957027 crossrefType "journal-article" @default.
- W2090957027 hasAuthorship W2090957027A5005900235 @default.
- W2090957027 hasAuthorship W2090957027A5018249388 @default.
- W2090957027 hasAuthorship W2090957027A5056053058 @default.
- W2090957027 hasAuthorship W2090957027A5061153948 @default.
- W2090957027 hasAuthorship W2090957027A5079594267 @default.
- W2090957027 hasAuthorship W2090957027A5083487683 @default.
- W2090957027 hasAuthorship W2090957027A5088055918 @default.
- W2090957027 hasAuthorship W2090957027A5089833045 @default.
- W2090957027 hasBestOaLocation W20909570271 @default.
- W2090957027 hasConcept C126322002 @default.
- W2090957027 hasConcept C126838900 @default.
- W2090957027 hasConcept C127413603 @default.
- W2090957027 hasConcept C142724271 @default.
- W2090957027 hasConcept C143409427 @default.
- W2090957027 hasConcept C150903083 @default.
- W2090957027 hasConcept C159654299 @default.
- W2090957027 hasConcept C16930146 @default.
- W2090957027 hasConcept C185592680 @default.
- W2090957027 hasConcept C203014093 @default.
- W2090957027 hasConcept C207001950 @default.
- W2090957027 hasConcept C26291073 @default.
- W2090957027 hasConcept C2775842073 @default.
- W2090957027 hasConcept C2776791281 @default.
- W2090957027 hasConcept C2778236600 @default.
- W2090957027 hasConcept C2779134260 @default.
- W2090957027 hasConcept C2780577055 @default.
- W2090957027 hasConcept C2780645631 @default.
- W2090957027 hasConcept C2989005 @default.