FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090957628> ?p ?o ?g. }

• W2090957628 endingPage "197" @default.
• W2090957628 startingPage "187" @default.
• W2090957628 abstract "Although normal intracellular levels of arginine are well above the K(m), and should be sufficient to saturate nitric oxide synthase in vascular endothelial cells, nitric oxide production can, nonetheless, be stimulated by exogenous arginine. This phenomenon, termed the arginine paradox, has suggested the existence of a separate pool of arginine directed to nitric oxide synthesis. In this study, we demonstrate that exogenous citrulline was as effective as exogenous arginine in stimulating nitric oxide production and that citrulline in the presence of excess intracellular and extracellular arginine further enhanced bradykinin stimulated endothelial nitric oxide production. The enhancement of nitric oxide production by exogenous citrulline could therefore be attributed to the capacity of vascular endothelial cells to efficiently regenerate arginine from citrulline. However, the regeneration of arginine did not affect the bulk intracellular arginine levels. This finding not only supports the proposal for a unique pool of arginine, but also suggested channeling of substrates that would require a functional association between nitric oxide production and arginine regeneration. To support this proposal, we showed that nitric oxide synthase, and the enzymes involved in arginine regeneration, argininosuccinate synthase and argininosuccinate lyase, cofractionated with plasmalemmal caveolae, a subcompartment of the plasma membrane. Overall, the results from this study strongly support the proposal for a separate pool of arginine for nitric oxide production that is defined by the cellular colocalization of enzymes involved in nitric oxide production and the regeneration of arginine." @default.
• W2090957628 created "2016-06-24" @default.
• W2090957628 creator A5000405222 @default.
• W2090957628 creator A5000977399 @default.
• W2090957628 creator A5034284433 @default.
• W2090957628 creator A5059704161 @default.
• W2090957628 creator A5088862489 @default.
• W2090957628 date "2001-04-01" @default.
• W2090957628 modified "2023-09-27" @default.
• W2090957628 title "Caveolar Localization of Arginine Regeneration Enzymes, Argininosuccinate Synthase, and Lyase, with Endothelial Nitric Oxide Synthase" @default.
• W2090957628 cites W1549194476 @default.
• W2090957628 cites W1558486290 @default.
• W2090957628 cites W1971979964 @default.
• W2090957628 cites W1980528903 @default.
• W2090957628 cites W1981596295 @default.
• W2090957628 cites W1983335262 @default.
• W2090957628 cites W1983471479 @default.
• W2090957628 cites W1999565215 @default.
• W2090957628 cites W2001687956 @default.
• W2090957628 cites W2001785527 @default.
• W2090957628 cites W2002787536 @default.
• W2090957628 cites W2006890214 @default.
• W2090957628 cites W2027223774 @default.
• W2090957628 cites W2028010937 @default.
• W2090957628 cites W2030599919 @default.
• W2090957628 cites W2032190558 @default.
• W2090957628 cites W2038505321 @default.
• W2090957628 cites W2042695353 @default.
• W2090957628 cites W2052055930 @default.
• W2090957628 cites W2056673785 @default.
• W2090957628 cites W2066431883 @default.
• W2090957628 cites W2068992159 @default.
• W2090957628 cites W2072102050 @default.
• W2090957628 cites W2161769916 @default.
• W2090957628 cites W2419604885 @default.
• W2090957628 doi "https://doi.org/10.1006/niox.2001.0340" @default.
• W2090957628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11292368" @default.
• W2090957628 hasPublicationYear "2001" @default.
• W2090957628 type Work @default.
• W2090957628 sameAs 2090957628 @default.
• W2090957628 citedByCount "100" @default.
• W2090957628 countsByYear W20909576282012 @default.
• W2090957628 countsByYear W20909576282013 @default.
• W2090957628 countsByYear W20909576282014 @default.
• W2090957628 countsByYear W20909576282015 @default.
• W2090957628 countsByYear W20909576282016 @default.
• W2090957628 countsByYear W20909576282017 @default.
• W2090957628 countsByYear W20909576282018 @default.
• W2090957628 countsByYear W20909576282019 @default.
• W2090957628 countsByYear W20909576282020 @default.
• W2090957628 countsByYear W20909576282021 @default.
• W2090957628 countsByYear W20909576282023 @default.
• W2090957628 crossrefType "journal-article" @default.
• W2090957628 hasAuthorship W2090957628A5000405222 @default.
• W2090957628 hasAuthorship W2090957628A5000977399 @default.
• W2090957628 hasAuthorship W2090957628A5034284433 @default.
• W2090957628 hasAuthorship W2090957628A5059704161 @default.
• W2090957628 hasAuthorship W2090957628A5088862489 @default.
• W2090957628 hasConcept C164007495 @default.
• W2090957628 hasConcept C178790620 @default.
• W2090957628 hasConcept C185592680 @default.
• W2090957628 hasConcept C188610204 @default.
• W2090957628 hasConcept C2776761436 @default.
• W2090957628 hasConcept C2777468819 @default.
• W2090957628 hasConcept C2777622882 @default.
• W2090957628 hasConcept C2779129087 @default.
• W2090957628 hasConcept C515207424 @default.
• W2090957628 hasConcept C519581460 @default.
• W2090957628 hasConcept C55493867 @default.
• W2090957628 hasConcept C86803240 @default.
• W2090957628 hasConcept C95444343 @default.
• W2090957628 hasConceptScore W2090957628C164007495 @default.
• W2090957628 hasConceptScore W2090957628C178790620 @default.
• W2090957628 hasConceptScore W2090957628C185592680 @default.
• W2090957628 hasConceptScore W2090957628C188610204 @default.
• W2090957628 hasConceptScore W2090957628C2776761436 @default.
• W2090957628 hasConceptScore W2090957628C2777468819 @default.
• W2090957628 hasConceptScore W2090957628C2777622882 @default.
• W2090957628 hasConceptScore W2090957628C2779129087 @default.
• W2090957628 hasConceptScore W2090957628C515207424 @default.
• W2090957628 hasConceptScore W2090957628C519581460 @default.
• W2090957628 hasConceptScore W2090957628C55493867 @default.
• W2090957628 hasConceptScore W2090957628C86803240 @default.
• W2090957628 hasConceptScore W2090957628C95444343 @default.
• W2090957628 hasIssue "2" @default.
• W2090957628 hasLocation W20909576281 @default.
• W2090957628 hasLocation W20909576282 @default.
• W2090957628 hasOpenAccess W2090957628 @default.
• W2090957628 hasPrimaryLocation W20909576281 @default.
• W2090957628 hasRelatedWork W1590164495 @default.
• W2090957628 hasRelatedWork W1997004647 @default.
• W2090957628 hasRelatedWork W2022915034 @default.
• W2090957628 hasRelatedWork W2090957628 @default.
• W2090957628 hasRelatedWork W2091476067 @default.
• W2090957628 hasRelatedWork W2093996623 @default.
• W2090957628 hasRelatedWork W2229097852 @default.
• W2090957628 hasRelatedWork W2283474845 @default.
• W2090957628 hasRelatedWork W3166865274 @default.

• next