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- W2090958233 abstract "Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks. The EC 50 * values for ADP and platelet-activating factor were significantly higher, whilst that for collagen was significantly lower in classical migraine patients during headache-free intervals compared to healthy volunteers. The EC 50 values obtained for common migraine sufferers during symptom-free periods were similar to those of controls. During attacks, the EC 50 value for ADP, but not for collagen and platelet-activating factor, was significantly higher than that of the controls. In healthy subjects a positive correlation was found between ADP and collagen-induced aggregation. In contrast, there was a U-shaped correlation matrix in classical migraine patients. The present observations show that platelet aggregation is altered in migraine patients and this raises the possibility that platelet-activating factor may be involved in the pathogenesis of migraine." @default.
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- W2090958233 date "1990-08-01" @default.
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- W2090958233 title "Platelet Aggregation of Migraineurs During and Between Attacks" @default.
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- W2090958233 doi "https://doi.org/10.1046/j.1468-2982.1990.1004161.x" @default.
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