FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090964521> ?p ?o ?g. }

• W2090964521 endingPage "1242" @default.
• W2090964521 startingPage "1237" @default.
• W2090964521 abstract "Ginger rhizome is used worldwide as a spicy flavor agent. This study was designed to explore the potential effects of pungent ginger components, 6-, 8-, and 10-gingerol, on human cytochrome P450 (CYP450) enzymes that are responsible for the metabolism of many prescription drugs. The activities of human CYP2C9, CYP2C19, CYP2D6, and CYP3A4 were analyzed using Vivid P450 assay kits. The mRNA expression of CYP3A4 in human hepatocellular carcinoma cell line HepG2 was measured using quantitative real-time PCR assay. All three gingerols potently inhibited CYP2C9 activity, exerted moderate inhibition on CYP2C19 and CYP3A4, and weak inhibion on CYP2D6. 8-Gingerol was the most potent in inhibition of P450 enzymes with IC50 values of 6.8, 12.5, 8.7, and 42.7 μmol/L for CYP2C9, CYP2C19, CYP3A4, and CYP2D6, respectively. By comparing the effects of gingerols on CYP3A4 with three different fluorescent substrate probes, it was demonstrated that the inhibition of gingerols on CYP3A4 had no substrate-dependence. In HepG2 cells, 8-gingerol and 10-gingerol inhibited, but 6-gingerol induced mRNA expression of CYP3A4. 6-, 8-, and 10-gingerol suppress human cytochrome P450 activity, while 8- and 10-gingerol inhibit CYP3A4 expression. The results may have an implication for the use of ginger or ginger products when combined with therapeutic drugs that are metabolized by cytochrome P450 enzymes." @default.
• W2090964521 created "2016-06-24" @default.
• W2090964521 creator A5030302953 @default.
• W2090964521 creator A5053507328 @default.
• W2090964521 creator A5076699095 @default.
• W2090964521 creator A5077209408 @default.
• W2090964521 creator A5084119323 @default.
• W2090964521 creator A5086966376 @default.
• W2090964521 creator A5090366405 @default.
• W2090964521 date "2013-06-17" @default.
• W2090964521 modified "2023-10-04" @default.
• W2090964521 title "Pungent ginger components modulates human cytochrome P450 enzymes in vitro" @default.
• W2090964521 cites W1967389878 @default.
• W2090964521 cites W1967542513 @default.
• W2090964521 cites W1980998456 @default.
• W2090964521 cites W1981021151 @default.
• W2090964521 cites W1983398527 @default.
• W2090964521 cites W1993274099 @default.
• W2090964521 cites W1994916345 @default.
• W2090964521 cites W2001342571 @default.
• W2090964521 cites W2004585767 @default.
• W2090964521 cites W2004951187 @default.
• W2090964521 cites W2012981591 @default.
• W2090964521 cites W2021775978 @default.
• W2090964521 cites W2021881010 @default.
• W2090964521 cites W2024544307 @default.
• W2090964521 cites W2029286778 @default.
• W2090964521 cites W2036316753 @default.
• W2090964521 cites W2040450167 @default.
• W2090964521 cites W2041801408 @default.
• W2090964521 cites W2072624946 @default.
• W2090964521 cites W2081241211 @default.
• W2090964521 cites W2112882492 @default.
• W2090964521 cites W2120906462 @default.
• W2090964521 cites W2121074897 @default.
• W2090964521 cites W2121345875 @default.
• W2090964521 cites W2123957412 @default.
• W2090964521 cites W2125899548 @default.
• W2090964521 cites W2149319043 @default.
• W2090964521 cites W2153935581 @default.
• W2090964521 cites W2158318124 @default.
• W2090964521 cites W2158345238 @default.
• W2090964521 cites W2169516198 @default.
• W2090964521 cites W2170202887 @default.
• W2090964521 cites W4229861383 @default.
• W2090964521 cites W4248725772 @default.
• W2090964521 doi "https://doi.org/10.1038/aps.2013.49" @default.
• W2090964521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003154" @default.
• W2090964521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23770984" @default.
• W2090964521 hasPublicationYear "2013" @default.
• W2090964521 type Work @default.
• W2090964521 sameAs 2090964521 @default.
• W2090964521 citedByCount "48" @default.
• W2090964521 countsByYear W20909645212013 @default.
• W2090964521 countsByYear W20909645212014 @default.
• W2090964521 countsByYear W20909645212015 @default.
• W2090964521 countsByYear W20909645212017 @default.
• W2090964521 countsByYear W20909645212018 @default.
• W2090964521 countsByYear W20909645212019 @default.
• W2090964521 countsByYear W20909645212020 @default.
• W2090964521 countsByYear W20909645212021 @default.
• W2090964521 countsByYear W20909645212022 @default.
• W2090964521 countsByYear W20909645212023 @default.
• W2090964521 crossrefType "journal-article" @default.
• W2090964521 hasAuthorship W2090964521A5030302953 @default.
• W2090964521 hasAuthorship W2090964521A5053507328 @default.
• W2090964521 hasAuthorship W2090964521A5076699095 @default.
• W2090964521 hasAuthorship W2090964521A5077209408 @default.
• W2090964521 hasAuthorship W2090964521A5084119323 @default.
• W2090964521 hasAuthorship W2090964521A5086966376 @default.
• W2090964521 hasAuthorship W2090964521A5090366405 @default.
• W2090964521 hasBestOaLocation W20909645211 @default.
• W2090964521 hasConcept C109650736 @default.
• W2090964521 hasConcept C140840227 @default.
• W2090964521 hasConcept C181199279 @default.
• W2090964521 hasConcept C185592680 @default.
• W2090964521 hasConcept C3946865 @default.
• W2090964521 hasConcept C526171541 @default.
• W2090964521 hasConcept C55493867 @default.
• W2090964521 hasConcept C86745063 @default.
• W2090964521 hasConcept C86803240 @default.
• W2090964521 hasConcept C87644729 @default.
• W2090964521 hasConcept C98274493 @default.
• W2090964521 hasConceptScore W2090964521C109650736 @default.
• W2090964521 hasConceptScore W2090964521C140840227 @default.
• W2090964521 hasConceptScore W2090964521C181199279 @default.
• W2090964521 hasConceptScore W2090964521C185592680 @default.
• W2090964521 hasConceptScore W2090964521C3946865 @default.
• W2090964521 hasConceptScore W2090964521C526171541 @default.
• W2090964521 hasConceptScore W2090964521C55493867 @default.
• W2090964521 hasConceptScore W2090964521C86745063 @default.
• W2090964521 hasConceptScore W2090964521C86803240 @default.
• W2090964521 hasConceptScore W2090964521C87644729 @default.
• W2090964521 hasConceptScore W2090964521C98274493 @default.
• W2090964521 hasIssue "9" @default.
• W2090964521 hasLocation W20909645211 @default.
• W2090964521 hasLocation W20909645212 @default.
• W2090964521 hasLocation W20909645213 @default.

• next