FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090967892> ?p ?o ?g. }

• W2090967892 endingPage "591" @default.
• W2090967892 startingPage "580" @default.
• W2090967892 abstract "Abstract Docking unbound molecules presents a challenge in the case where no prior biological or bioinformatic knowledge exists. This is mainly due to differences between the structures of the molecules when in a complex and in the free state. Presumably, these differences interfere with the ability of protein–protein docking algorithms, which rely on a dominant shape descriptor, to identify the correct solution and rank it higher than false solutions. In this study we verify the notion that small discords in the molecular fit can be eliminated by using appropriately designed low‐resolution shape descriptors, thereby improving the docking results. We exploit the inherent gradual resolution dependency of Fourier transforms and formulate a resolution‐dependent shape descriptor by truncating selected Fourier transform terms. Thus, different levels of shape modification are attained, affecting the degree of detail in the depiction of the molecular surface. We applied the modified descriptor to a selection of 23 protein–protein systems, using the unbound structures where possible. The docking results obtained with the new geometric descriptor were considerably superior to former results, improving the ranks of nearly correct solutions for 17 systems. Unification of the results of scans in which different resolutions were employed further improved the ranks of nearly correct solutions to less than 100 for 12 of the 23 systems and less than 300 for 20 systems. The new geometric descriptor can be combined with other descriptors, which typify the electrostatic or hydrophobic character of the molecular surface, and with external experimental or bioinformatic data. Proteins 2005. © 2005 Wiley‐Liss, Inc." @default.
• W2090967892 created "2016-06-24" @default.
• W2090967892 creator A5028551465 @default.
• W2090967892 creator A5034188321 @default.
• W2090967892 date "2005-03-18" @default.
• W2090967892 modified "2023-10-17" @default.
• W2090967892 title "The effect of resolution-dependent global shape modifications on rigid-body protein-protein docking" @default.
• W2090967892 cites W1540438931 @default.
• W2090967892 cites W1566359595 @default.
• W2090967892 cites W1955046737 @default.
• W2090967892 cites W1977385571 @default.
• W2090967892 cites W1980460653 @default.
• W2090967892 cites W1989670701 @default.
• W2090967892 cites W1992864103 @default.
• W2090967892 cites W1997509365 @default.
• W2090967892 cites W2000383223 @default.
• W2090967892 cites W2000464453 @default.
• W2090967892 cites W2004584341 @default.
• W2090967892 cites W2005049999 @default.
• W2090967892 cites W2011214542 @default.
• W2090967892 cites W2012925450 @default.
• W2090967892 cites W2021293338 @default.
• W2090967892 cites W2022284509 @default.
• W2090967892 cites W2027393660 @default.
• W2090967892 cites W2030219831 @default.
• W2090967892 cites W2041797655 @default.
• W2090967892 cites W2043335148 @default.
• W2090967892 cites W2043449832 @default.
• W2090967892 cites W2043516837 @default.
• W2090967892 cites W2045585155 @default.
• W2090967892 cites W2047039535 @default.
• W2090967892 cites W2047709322 @default.
• W2090967892 cites W2057042085 @default.
• W2090967892 cites W2059230162 @default.
• W2090967892 cites W2063109965 @default.
• W2090967892 cites W2064811345 @default.
• W2090967892 cites W2067455153 @default.
• W2090967892 cites W2068115563 @default.
• W2090967892 cites W2070606233 @default.
• W2090967892 cites W2071379421 @default.
• W2090967892 cites W2071870135 @default.
• W2090967892 cites W2073833271 @default.
• W2090967892 cites W2078072629 @default.
• W2090967892 cites W2082190144 @default.
• W2090967892 cites W2089949506 @default.
• W2090967892 cites W2091353481 @default.
• W2090967892 cites W2094130520 @default.
• W2090967892 cites W2098451745 @default.
• W2090967892 cites W2103125723 @default.
• W2090967892 cites W2107202459 @default.
• W2090967892 cites W2112194058 @default.
• W2090967892 cites W2112366188 @default.
• W2090967892 cites W2114621223 @default.
• W2090967892 cites W2116075649 @default.
• W2090967892 cites W2118459915 @default.
• W2090967892 cites W2124755578 @default.
• W2090967892 cites W2130280638 @default.
• W2090967892 cites W2130479394 @default.
• W2090967892 cites W2134268392 @default.
• W2090967892 cites W2137890647 @default.
• W2090967892 cites W2140642212 @default.
• W2090967892 cites W2142747988 @default.
• W2090967892 cites W2143069456 @default.
• W2090967892 cites W2152561142 @default.
• W2090967892 cites W2153207100 @default.
• W2090967892 cites W2159192805 @default.
• W2090967892 cites W2162502996 @default.
• W2090967892 cites W2166606314 @default.
• W2090967892 cites W2169085737 @default.
• W2090967892 cites W2171356751 @default.
• W2090967892 cites W4230539260 @default.
• W2090967892 cites W4238204744 @default.
• W2090967892 cites W4293226720 @default.
• W2090967892 cites W2784950497 @default.
• W2090967892 doi "https://doi.org/10.1002/prot.20432" @default.
• W2090967892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15778956" @default.
• W2090967892 hasPublicationYear "2005" @default.
• W2090967892 type Work @default.
• W2090967892 sameAs 2090967892 @default.
• W2090967892 citedByCount "5" @default.
• W2090967892 crossrefType "journal-article" @default.
• W2090967892 hasAuthorship W2090967892A5028551465 @default.
• W2090967892 hasAuthorship W2090967892A5034188321 @default.
• W2090967892 hasConcept C11413529 @default.
• W2090967892 hasConcept C127313418 @default.
• W2090967892 hasConcept C138268822 @default.
• W2090967892 hasConcept C154945302 @default.
• W2090967892 hasConcept C159110408 @default.
• W2090967892 hasConcept C185592680 @default.
• W2090967892 hasConcept C186060115 @default.
• W2090967892 hasConcept C3019883945 @default.
• W2090967892 hasConcept C3020199158 @default.
• W2090967892 hasConcept C41008148 @default.
• W2090967892 hasConcept C41685203 @default.
• W2090967892 hasConcept C44695244 @default.
• W2090967892 hasConcept C47701112 @default.
• W2090967892 hasConcept C55493867 @default.
• W2090967892 hasConcept C62649853 @default.

• next