Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090968612> ?p ?o ?g. }
- W2090968612 endingPage "419" @default.
- W2090968612 startingPage "411" @default.
- W2090968612 abstract "Atherosclerosis and diabetes are closely associated and both involve extensive degradation of the aortic elastin. Increased elastase activity has been detected in diabetic animal aortae. We have demonstrated enhanced elastolytic cathepsin S in human atherosclerotic lesions but insufficient amounts of its endogenous inhibitor cystatin C, suggesting alterations of serum cathepsin S and/or cystatin C in patients with atherosclerosis or diabetes. In this study, we measured levels of both cathepsin S and cystatin C in sera from 240 patients by ELISA. Among these patients, 107 had a diagnosis of atherosclerotic stenosis, 103 were diabetic, and 30 had neither condition. Multiple linear regression analysis demonstrated that significantly higher serum levels of cathepsin S in patients with either atherosclerotic stenosis (p<0.04) or diabetes (p=0.0005) persisted after adjustment for cystatin C level, renal function, smoking, and serum glucose levels (p=0.008, p=0.0005). Furthermore, patients with acute (p=0.009) or previous myocardial infarction (p<0.02) or unstable angina pectoris (p<0.05) had elevated levels of cathepsin S after adjustment for smoking, creatinine, cystatin C, and serum glucose. In contrast, serum cystatin C levels were higher in diabetic patients (p=0.00001), but not in atherosclerotic subjects (p=0.14), than in the non-involved population after adjustment for age, smoking, and renal function. Although the pathophysiology of cathepsin S or cystatin C in atherosclerosis and diabetes requires further investigation, increased serum cathepsin S may serve as a biomarker for both diseases." @default.
- W2090968612 created "2016-06-24" @default.
- W2090968612 creator A5005654500 @default.
- W2090968612 creator A5010426461 @default.
- W2090968612 creator A5013989009 @default.
- W2090968612 creator A5021705916 @default.
- W2090968612 creator A5038803303 @default.
- W2090968612 creator A5050099342 @default.
- W2090968612 creator A5051028680 @default.
- W2090968612 creator A5052090282 @default.
- W2090968612 creator A5060165452 @default.
- W2090968612 creator A5060786706 @default.
- W2090968612 creator A5090298096 @default.
- W2090968612 date "2006-06-01" @default.
- W2090968612 modified "2023-10-13" @default.
- W2090968612 title "Increased serum cathepsin S in patients with atherosclerosis and diabetes" @default.
- W2090968612 cites W184828365 @default.
- W2090968612 cites W1965029028 @default.
- W2090968612 cites W1969791968 @default.
- W2090968612 cites W1980295273 @default.
- W2090968612 cites W1982584622 @default.
- W2090968612 cites W1986316605 @default.
- W2090968612 cites W1988296336 @default.
- W2090968612 cites W1989060257 @default.
- W2090968612 cites W1989853123 @default.
- W2090968612 cites W1994641823 @default.
- W2090968612 cites W2007088839 @default.
- W2090968612 cites W2015310647 @default.
- W2090968612 cites W2019978702 @default.
- W2090968612 cites W2031575410 @default.
- W2090968612 cites W2042327438 @default.
- W2090968612 cites W2050484848 @default.
- W2090968612 cites W2057157925 @default.
- W2090968612 cites W2065250447 @default.
- W2090968612 cites W2071605664 @default.
- W2090968612 cites W2078566293 @default.
- W2090968612 cites W2081105252 @default.
- W2090968612 cites W2083501039 @default.
- W2090968612 cites W2087081025 @default.
- W2090968612 cites W2090262871 @default.
- W2090968612 cites W2097619603 @default.
- W2090968612 cites W2098184356 @default.
- W2090968612 cites W2102289397 @default.
- W2090968612 cites W2111066407 @default.
- W2090968612 cites W2119193879 @default.
- W2090968612 cites W2121696981 @default.
- W2090968612 cites W2127557759 @default.
- W2090968612 cites W2129850517 @default.
- W2090968612 cites W2134704572 @default.
- W2090968612 cites W2153157231 @default.
- W2090968612 cites W2154922982 @default.
- W2090968612 cites W2161273477 @default.
- W2090968612 cites W2162303653 @default.
- W2090968612 cites W2163127813 @default.
- W2090968612 cites W2165354092 @default.
- W2090968612 cites W2165404205 @default.
- W2090968612 cites W2325198252 @default.
- W2090968612 cites W4235531951 @default.
- W2090968612 cites W4239747187 @default.
- W2090968612 cites W4255978432 @default.
- W2090968612 cites W4296979652 @default.
- W2090968612 doi "https://doi.org/10.1016/j.atherosclerosis.2005.08.001" @default.
- W2090968612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16140306" @default.
- W2090968612 hasPublicationYear "2006" @default.
- W2090968612 type Work @default.
- W2090968612 sameAs 2090968612 @default.
- W2090968612 citedByCount "109" @default.
- W2090968612 countsByYear W20909686122012 @default.
- W2090968612 countsByYear W20909686122013 @default.
- W2090968612 countsByYear W20909686122014 @default.
- W2090968612 countsByYear W20909686122015 @default.
- W2090968612 countsByYear W20909686122016 @default.
- W2090968612 countsByYear W20909686122017 @default.
- W2090968612 countsByYear W20909686122018 @default.
- W2090968612 countsByYear W20909686122019 @default.
- W2090968612 countsByYear W20909686122020 @default.
- W2090968612 countsByYear W20909686122021 @default.
- W2090968612 countsByYear W20909686122022 @default.
- W2090968612 countsByYear W20909686122023 @default.
- W2090968612 crossrefType "journal-article" @default.
- W2090968612 hasAuthorship W2090968612A5005654500 @default.
- W2090968612 hasAuthorship W2090968612A5010426461 @default.
- W2090968612 hasAuthorship W2090968612A5013989009 @default.
- W2090968612 hasAuthorship W2090968612A5021705916 @default.
- W2090968612 hasAuthorship W2090968612A5038803303 @default.
- W2090968612 hasAuthorship W2090968612A5050099342 @default.
- W2090968612 hasAuthorship W2090968612A5051028680 @default.
- W2090968612 hasAuthorship W2090968612A5052090282 @default.
- W2090968612 hasAuthorship W2090968612A5060165452 @default.
- W2090968612 hasAuthorship W2090968612A5060786706 @default.
- W2090968612 hasAuthorship W2090968612A5090298096 @default.
- W2090968612 hasConcept C126322002 @default.
- W2090968612 hasConcept C134018914 @default.
- W2090968612 hasConcept C151701858 @default.
- W2090968612 hasConcept C159641895 @default.
- W2090968612 hasConcept C167844969 @default.
- W2090968612 hasConcept C181199279 @default.
- W2090968612 hasConcept C2779548226 @default.