FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090969788> ?p ?o ?g. }

• W2090969788 endingPage "2447" @default.
• W2090969788 startingPage "2438" @default.
• W2090969788 abstract "Elmo is an evolutionarily conserved mammalian ortholog of Caenorhabditis elegans CED-12 with proposed roles during the removal of apoptotic cells, cell migration, neurite outgrowth, and myoblast fusion (Katoh and Negishi (2003) [1], Park and Tosello (2007) [2], Grimsley et al. (2004) [3], Hamoud et al. (2014) [4]). Elmo mediates these cellular processes by interacting with various proteins located in the plasma membrane, cytoplasm and nucleus, and by modulating their activities although it has no intrinsic catalytic activity (Park and Tosello (2007) [2], Hamoud et al. (2014) [4], Li et al. (2013) [5], Margaron, Fradet and Cote (2013) [6], and Mauldin et al. (2013)[7]). Because there are a limited number of proteins known to interact with Elmo, we performed a yeast two-hybrid screen using Elmo1 as bait to identify Elmo1-interacting proteins and to evaluate their mode of regulation. Arhgef16 was one of the proteins identified through the screen and subsequent analyses revealed that Arhgef16 interacted with Elmo1 in mammalian cells as well. Expression of Arhgef16 in phagocytes promoted engulfment of apoptotic cells, and engulfment mediated by Arhgef16 increased synergistically in the presence of Elmo1 but was abrogated in the absence of Elmo1. In addition, Arhgef16-mediated removal of apoptotic cells was dependent on RhoG, but independent of Dock1. Taken together, this study suggests that the newly identified Elmo1-interacting protein, Arhgef16, functions synergistically with Elmo1 to promote clearance of apoptotic cells in a RhoG-dependent and Dock1-independent manner." @default.
• W2090969788 created "2016-06-24" @default.
• W2090969788 creator A5001964761 @default.
• W2090969788 creator A5018465087 @default.
• W2090969788 creator A5030527091 @default.
• W2090969788 creator A5034947656 @default.
• W2090969788 creator A5038806687 @default.
• W2090969788 creator A5049754326 @default.
• W2090969788 creator A5075004016 @default.
• W2090969788 creator A5088811678 @default.
• W2090969788 creator A5090917103 @default.
• W2090969788 date "2014-11-01" @default.
• W2090969788 modified "2023-10-02" @default.
• W2090969788 title "Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation" @default.
• W2090969788 cites W1483786899 @default.
• W2090969788 cites W1535657576 @default.
• W2090969788 cites W1577875470 @default.
• W2090969788 cites W1924646174 @default.
• W2090969788 cites W1971275554 @default.
• W2090969788 cites W1981945461 @default.
• W2090969788 cites W1983097317 @default.
• W2090969788 cites W1989479275 @default.
• W2090969788 cites W1997708855 @default.
• W2090969788 cites W2000546459 @default.
• W2090969788 cites W2002699122 @default.
• W2090969788 cites W2003866119 @default.
• W2090969788 cites W2006860577 @default.
• W2090969788 cites W2007289852 @default.
• W2090969788 cites W2009542532 @default.
• W2090969788 cites W2025896887 @default.
• W2090969788 cites W2031746153 @default.
• W2090969788 cites W2064238899 @default.
• W2090969788 cites W2069986934 @default.
• W2090969788 cites W2071481601 @default.
• W2090969788 cites W2074502503 @default.
• W2090969788 cites W2075318281 @default.
• W2090969788 cites W2080689645 @default.
• W2090969788 cites W2083933935 @default.
• W2090969788 cites W2095189716 @default.
• W2090969788 cites W2095263396 @default.
• W2090969788 cites W2108414389 @default.
• W2090969788 cites W2114936261 @default.
• W2090969788 cites W2132251729 @default.
• W2090969788 cites W2144349655 @default.
• W2090969788 cites W2147670015 @default.
• W2090969788 cites W2170665989 @default.
• W2090969788 cites W2170872197 @default.
• W2090969788 doi "https://doi.org/10.1016/j.bbamcr.2014.07.006" @default.
• W2090969788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063526" @default.
• W2090969788 hasPublicationYear "2014" @default.
• W2090969788 type Work @default.
• W2090969788 sameAs 2090969788 @default.
• W2090969788 citedByCount "22" @default.
• W2090969788 countsByYear W20909697882015 @default.
• W2090969788 countsByYear W20909697882016 @default.
• W2090969788 countsByYear W20909697882017 @default.
• W2090969788 countsByYear W20909697882018 @default.
• W2090969788 countsByYear W20909697882019 @default.
• W2090969788 countsByYear W20909697882020 @default.
• W2090969788 countsByYear W20909697882021 @default.
• W2090969788 countsByYear W20909697882022 @default.
• W2090969788 countsByYear W20909697882023 @default.
• W2090969788 crossrefType "journal-article" @default.
• W2090969788 hasAuthorship W2090969788A5001964761 @default.
• W2090969788 hasAuthorship W2090969788A5018465087 @default.
• W2090969788 hasAuthorship W2090969788A5030527091 @default.
• W2090969788 hasAuthorship W2090969788A5034947656 @default.
• W2090969788 hasAuthorship W2090969788A5038806687 @default.
• W2090969788 hasAuthorship W2090969788A5049754326 @default.
• W2090969788 hasAuthorship W2090969788A5075004016 @default.
• W2090969788 hasAuthorship W2090969788A5088811678 @default.
• W2090969788 hasAuthorship W2090969788A5090917103 @default.
• W2090969788 hasBestOaLocation W20909697881 @default.
• W2090969788 hasConcept C137738243 @default.
• W2090969788 hasConcept C1491633281 @default.
• W2090969788 hasConcept C185592680 @default.
• W2090969788 hasConcept C190283241 @default.
• W2090969788 hasConcept C2779717556 @default.
• W2090969788 hasConcept C55493867 @default.
• W2090969788 hasConcept C62478195 @default.
• W2090969788 hasConcept C86803240 @default.
• W2090969788 hasConcept C95444343 @default.
• W2090969788 hasConceptScore W2090969788C137738243 @default.
• W2090969788 hasConceptScore W2090969788C1491633281 @default.
• W2090969788 hasConceptScore W2090969788C185592680 @default.
• W2090969788 hasConceptScore W2090969788C190283241 @default.
• W2090969788 hasConceptScore W2090969788C2779717556 @default.
• W2090969788 hasConceptScore W2090969788C55493867 @default.
• W2090969788 hasConceptScore W2090969788C62478195 @default.
• W2090969788 hasConceptScore W2090969788C86803240 @default.
• W2090969788 hasConceptScore W2090969788C95444343 @default.
• W2090969788 hasFunder F4320322120 @default.
• W2090969788 hasIssue "11" @default.
• W2090969788 hasLocation W20909697881 @default.
• W2090969788 hasLocation W20909697882 @default.
• W2090969788 hasOpenAccess W2090969788 @default.
• W2090969788 hasPrimaryLocation W20909697881 @default.
• W2090969788 hasRelatedWork W1953910109 @default.

• next