FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090970075> ?p ?o ?g. }

• W2090970075 endingPage "558" @default.
• W2090970075 startingPage "540" @default.
• W2090970075 abstract "1. Prazosin, 2-[4-(2-furanoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, is an antihypertensive agent that has been used safely since 1976 and is currently being investigated for the treatment of post-traumatic stress disorder. The in vivo metabolism of prazosin in rat was first reported in 1977, although at the time analytical techniques were not as sophisticated, nor were the mass spectrometers as sensitive, as today. Recently, the in vitro metabolism of prazosin in rat liver microsomes and cryopreserved hepatocytes was investigated using liquid chromatography/mass spectrometry (LC/MS), which revealed new metabolic pathways.2. In the present work, rat in vivo metabolism was reinvestigated using a quadrupole time-of-flight mass spectrometer coupled with ultra-performance liquid chromatography, or chip-based nanoflow electrospray ionization, with the aim of identifying metabolites revealed by the in vitro studies and any new metabolites.3. It is reported that prazosin was metabolized in rats to produce the metabolites observed in vitro. In addition, new phase I metabolites, M18, M20 and M21, were formed and conjugation with glucose or taurine formed the new phase II metabolites, M16 and M19, respectively.4. Evidence for bioactivation of prazosin included detection of ring-opened metabolites (M4 and M7) and a cysteinyl–glycine conjugate (M17). Further support to the structure of the ring-opened metabolite M7 was obtained by nuclear magnetic resonance (NMR) experiments on M7 isolated from urine." @default.
• W2090970075 created "2016-06-24" @default.
• W2090970075 creator A5038020766 @default.
• W2090970075 creator A5041945808 @default.
• W2090970075 creator A5042690105 @default.
• W2090970075 creator A5047352514 @default.
• W2090970075 creator A5056438621 @default.
• W2090970075 creator A5074731229 @default.
• W2090970075 creator A5074980126 @default.
• W2090970075 date "2008-05-01" @default.
• W2090970075 modified "2023-10-18" @default.
• W2090970075 title "Metabolism of prazosin in rat and characterization of metabolites in plasma, urine, faeces, brain and bile using liquid chromatography/mass spectrometry (LC/MS)" @default.
• W2090970075 cites W1974127394 @default.
• W2090970075 cites W1983926671 @default.
• W2090970075 cites W1989485566 @default.
• W2090970075 cites W2008462293 @default.
• W2090970075 cites W2024071094 @default.
• W2090970075 cites W2024863909 @default.
• W2090970075 cites W2052696959 @default.
• W2090970075 cites W2061684362 @default.
• W2090970075 cites W2063229995 @default.
• W2090970075 cites W2078995073 @default.
• W2090970075 cites W2084513035 @default.
• W2090970075 cites W2102278308 @default.
• W2090970075 cites W2109860993 @default.
• W2090970075 cites W2113716869 @default.
• W2090970075 cites W2136022660 @default.
• W2090970075 cites W2138464780 @default.
• W2090970075 cites W2147258424 @default.
• W2090970075 cites W2155318267 @default.
• W2090970075 cites W2159301944 @default.
• W2090970075 cites W2162150396 @default.
• W2090970075 cites W2296533119 @default.
• W2090970075 cites W2328191364 @default.
• W2090970075 doi "https://doi.org/10.1080/00498250802001826" @default.
• W2090970075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18421626" @default.
• W2090970075 hasPublicationYear "2008" @default.
• W2090970075 type Work @default.
• W2090970075 sameAs 2090970075 @default.
• W2090970075 citedByCount "22" @default.
• W2090970075 countsByYear W20909700752012 @default.
• W2090970075 countsByYear W20909700752013 @default.
• W2090970075 countsByYear W20909700752014 @default.
• W2090970075 countsByYear W20909700752016 @default.
• W2090970075 countsByYear W20909700752017 @default.
• W2090970075 countsByYear W20909700752019 @default.
• W2090970075 countsByYear W20909700752022 @default.
• W2090970075 countsByYear W20909700752023 @default.
• W2090970075 crossrefType "journal-article" @default.
• W2090970075 hasAuthorship W2090970075A5038020766 @default.
• W2090970075 hasAuthorship W2090970075A5041945808 @default.
• W2090970075 hasAuthorship W2090970075A5042690105 @default.
• W2090970075 hasAuthorship W2090970075A5047352514 @default.
• W2090970075 hasAuthorship W2090970075A5056438621 @default.
• W2090970075 hasAuthorship W2090970075A5074731229 @default.
• W2090970075 hasAuthorship W2090970075A5074980126 @default.
• W2090970075 hasConcept C150903083 @default.
• W2090970075 hasConcept C162356407 @default.
• W2090970075 hasConcept C170493617 @default.
• W2090970075 hasConcept C185592680 @default.
• W2090970075 hasConcept C192989942 @default.
• W2090970075 hasConcept C207001950 @default.
• W2090970075 hasConcept C2776885963 @default.
• W2090970075 hasConcept C2777477808 @default.
• W2090970075 hasConcept C2779701627 @default.
• W2090970075 hasConcept C2780648677 @default.
• W2090970075 hasConcept C40684141 @default.
• W2090970075 hasConcept C43617362 @default.
• W2090970075 hasConcept C515207424 @default.
• W2090970075 hasConcept C55493867 @default.
• W2090970075 hasConcept C62231903 @default.
• W2090970075 hasConcept C86803240 @default.
• W2090970075 hasConcept C89311334 @default.
• W2090970075 hasConceptScore W2090970075C150903083 @default.
• W2090970075 hasConceptScore W2090970075C162356407 @default.
• W2090970075 hasConceptScore W2090970075C170493617 @default.
• W2090970075 hasConceptScore W2090970075C185592680 @default.
• W2090970075 hasConceptScore W2090970075C192989942 @default.
• W2090970075 hasConceptScore W2090970075C207001950 @default.
• W2090970075 hasConceptScore W2090970075C2776885963 @default.
• W2090970075 hasConceptScore W2090970075C2777477808 @default.
• W2090970075 hasConceptScore W2090970075C2779701627 @default.
• W2090970075 hasConceptScore W2090970075C2780648677 @default.
• W2090970075 hasConceptScore W2090970075C40684141 @default.
• W2090970075 hasConceptScore W2090970075C43617362 @default.
• W2090970075 hasConceptScore W2090970075C515207424 @default.
• W2090970075 hasConceptScore W2090970075C55493867 @default.
• W2090970075 hasConceptScore W2090970075C62231903 @default.
• W2090970075 hasConceptScore W2090970075C86803240 @default.
• W2090970075 hasConceptScore W2090970075C89311334 @default.
• W2090970075 hasIssue "5" @default.
• W2090970075 hasLocation W20909700751 @default.
• W2090970075 hasLocation W20909700752 @default.
• W2090970075 hasOpenAccess W2090970075 @default.
• W2090970075 hasPrimaryLocation W20909700751 @default.
• W2090970075 hasRelatedWork W2007659624 @default.
• W2090970075 hasRelatedWork W2019780857 @default.
• W2090970075 hasRelatedWork W2057858653 @default.

• next