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- W2090975152 abstract "Dissociation of apolipoprotein A-I from pig and steer high density lipoproteins (HDL) deficient in apoA-II was determined by exposing native HDL fractions to 6 M guanidine hydrochloride (Gdn-HCl) at 37°C for periods from 5 min to 18 h. Bovine high density lipoprotein (HDL-B) was isolated at d 1.063–1.100 g/ml while porcine high density lipoprotein (HDL-P) was isolated at d 1.125–1.21 g/ml. Incubation for 5 min with Gdn-HCl resulted in a 45 and 3% loss of apoA-I from HDL-P and HDL-B, respectively. Exposure to the denaturant for 3 h resulted in a 75% loss of apoA-I from HDL-P and a 30% loss from HDL-B. Analytic ultracentrifugation patterns paralleled the degree of apoA-I dissociation from each HDL species. The initial flotation peak for HDLP shifted from F°1.20 2.68 to F°1.20 10.75 after 3 h exposure while HDL-B showed only a small shift from F°1.20 8.30 to F°1.20 8.96 after 3 h exposure. HDL-P particle diameter increased 25% after 5 min of Gdn-HCl treatment and large, flattened structures predominated after 3 h. There was no change in the size of HDL-B after 5 min exposure and only 16% increase in particle diameter after 3 h. The difference in behavior of HDL-B and HDL-P to Gdn-HCl exposure is discussed in terms of differences in apolipoprotein A-I amino acid composition, interaction of apolipoprotein A-I with phospholipids and the possible involvement of the cholesteryl ester core." @default.
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- W2090975152 date "1979-06-01" @default.
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- W2090975152 title "Dissociation of apolipoprotein A-I from porcine and bovine high density lipoproteins by guanidine hydrochloride" @default.
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- W2090975152 doi "https://doi.org/10.1016/0005-2760(79)90220-0" @default.
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