FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090976146> ?p ?o ?g. }

• W2090976146 endingPage "122" @default.
• W2090976146 startingPage "118" @default.
• W2090976146 abstract "In order to overcome the skin’s excellent barrier function formulation scientists often employ skin penetration enhancers (SPEs) in topical and transdermal formulations. The effects of these compounds on skin health is still not well understood at the molecular level. The aim of the present work was to probe the effects of some common SPEs on desquamatory protease activity in healthy skin. The SPEs studied were isopropyl myristate (IPM), propylene glycol, (PG), propylene glycol laurate (PGL) and Transcutol™ (TC). Occluded infinite doses of each SPE were applied to human volunteers for 24 h. Transepidermal water loss (TEWL) measurements were taken before and after application of SPEs. Tape strips were collected from the treated sites to determine protein content and the activity of two desquamatory proteases kallikrein 5 (KLK5) and kallikrein 7 (KLK7). TEWL values were also measured after tape stripping. PG was found to elevate both TEWL values and KLK7 activity to a significant extent (p < 0.05). No significant effects were observed for the other SPEs. The ability of PG to alter the skin barrier at the macroscopic level and the influence of the molecule on protease activity reported here may have implications for its use in topical formulations used for the management of impaired skin barrier function such as atopic eczema or psoriasis." @default.
• W2090976146 created "2016-06-24" @default.
• W2090976146 creator A5029198962 @default.
• W2090976146 creator A5032890158 @default.
• W2090976146 creator A5052902709 @default.
• W2090976146 creator A5057884872 @default.
• W2090976146 date "2014-01-01" @default.
• W2090976146 modified "2023-10-12" @default.
• W2090976146 title "Influence of skin penetration enhancers on skin barrier function and skin protease activity" @default.
• W2090976146 cites W106873267 @default.
• W2090976146 cites W1523565432 @default.
• W2090976146 cites W1557546950 @default.
• W2090976146 cites W1872675327 @default.
• W2090976146 cites W1978537309 @default.
• W2090976146 cites W1978858571 @default.
• W2090976146 cites W1988397135 @default.
• W2090976146 cites W1993990175 @default.
• W2090976146 cites W2009802132 @default.
• W2090976146 cites W2011826230 @default.
• W2090976146 cites W2015248164 @default.
• W2090976146 cites W2015490928 @default.
• W2090976146 cites W2018911196 @default.
• W2090976146 cites W2026302279 @default.
• W2090976146 cites W2036384651 @default.
• W2090976146 cites W2056078696 @default.
• W2090976146 cites W2067115907 @default.
• W2090976146 cites W2093317972 @default.
• W2090976146 cites W2094616623 @default.
• W2090976146 cites W2094642985 @default.
• W2090976146 cites W2124198517 @default.
• W2090976146 cites W2150229563 @default.
• W2090976146 cites W2155012357 @default.
• W2090976146 cites W4211043182 @default.
• W2090976146 cites W4230638667 @default.
• W2090976146 doi "https://doi.org/10.1016/j.ejps.2013.09.009" @default.
• W2090976146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24063883" @default.
• W2090976146 hasPublicationYear "2014" @default.
• W2090976146 type Work @default.
• W2090976146 sameAs 2090976146 @default.
• W2090976146 citedByCount "47" @default.
• W2090976146 countsByYear W20909761462014 @default.
• W2090976146 countsByYear W20909761462015 @default.
• W2090976146 countsByYear W20909761462016 @default.
• W2090976146 countsByYear W20909761462017 @default.
• W2090976146 countsByYear W20909761462018 @default.
• W2090976146 countsByYear W20909761462019 @default.
• W2090976146 countsByYear W20909761462020 @default.
• W2090976146 countsByYear W20909761462021 @default.
• W2090976146 countsByYear W20909761462023 @default.
• W2090976146 crossrefType "journal-article" @default.
• W2090976146 hasAuthorship W2090976146A5029198962 @default.
• W2090976146 hasAuthorship W2090976146A5032890158 @default.
• W2090976146 hasAuthorship W2090976146A5052902709 @default.
• W2090976146 hasAuthorship W2090976146A5057884872 @default.
• W2090976146 hasConcept C127413603 @default.
• W2090976146 hasConcept C142724271 @default.
• W2090976146 hasConcept C181199279 @default.
• W2090976146 hasConcept C182220744 @default.
• W2090976146 hasConcept C185592680 @default.
• W2090976146 hasConcept C205679159 @default.
• W2090976146 hasConcept C2776714187 @default.
• W2090976146 hasConcept C2778370115 @default.
• W2090976146 hasConcept C2779783494 @default.
• W2090976146 hasConcept C42475967 @default.
• W2090976146 hasConcept C43617362 @default.
• W2090976146 hasConcept C51911345 @default.
• W2090976146 hasConcept C52853521 @default.
• W2090976146 hasConcept C55493867 @default.
• W2090976146 hasConcept C71924100 @default.
• W2090976146 hasConcept C80107235 @default.
• W2090976146 hasConcept C86803240 @default.
• W2090976146 hasConcept C95150158 @default.
• W2090976146 hasConcept C95444343 @default.
• W2090976146 hasConcept C98274493 @default.
• W2090976146 hasConceptScore W2090976146C127413603 @default.
• W2090976146 hasConceptScore W2090976146C142724271 @default.
• W2090976146 hasConceptScore W2090976146C181199279 @default.
• W2090976146 hasConceptScore W2090976146C182220744 @default.
• W2090976146 hasConceptScore W2090976146C185592680 @default.
• W2090976146 hasConceptScore W2090976146C205679159 @default.
• W2090976146 hasConceptScore W2090976146C2776714187 @default.
• W2090976146 hasConceptScore W2090976146C2778370115 @default.
• W2090976146 hasConceptScore W2090976146C2779783494 @default.
• W2090976146 hasConceptScore W2090976146C42475967 @default.
• W2090976146 hasConceptScore W2090976146C43617362 @default.
• W2090976146 hasConceptScore W2090976146C51911345 @default.
• W2090976146 hasConceptScore W2090976146C52853521 @default.
• W2090976146 hasConceptScore W2090976146C55493867 @default.
• W2090976146 hasConceptScore W2090976146C71924100 @default.
• W2090976146 hasConceptScore W2090976146C80107235 @default.
• W2090976146 hasConceptScore W2090976146C86803240 @default.
• W2090976146 hasConceptScore W2090976146C95150158 @default.
• W2090976146 hasConceptScore W2090976146C95444343 @default.
• W2090976146 hasConceptScore W2090976146C98274493 @default.
• W2090976146 hasLocation W20909761461 @default.
• W2090976146 hasLocation W20909761462 @default.
• W2090976146 hasOpenAccess W2090976146 @default.
• W2090976146 hasPrimaryLocation W20909761461 @default.

• next