Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090977130> ?p ?o ?g. }
- W2090977130 endingPage "28" @default.
- W2090977130 startingPage "11" @default.
- W2090977130 abstract "The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect profile. They differ, however, in their pharmacokinetic properties. Under steady-state concentrations, their half-lives range between 1 and 4 days for fluoxetine (7 and 15 days for norfluoxetine) and between 21 (paroxetine) and 36 (citalopram) hr for the other SSRIs. Sertraline and citalopram show linear and fluoxetine, fluvoxamine, and paroxetine nonlinear pharmacokinetics. SSRIs underlie an extensive metabolism with high interindividual variability, whereby cytochrome P450 (CYP) isoenzymes play a major role. Therefore, resulting blood concentrations are highly variable between individuals. Except for N-demethylated fluoxetine, metabolites of SSRIs do not contribute to clinical actions. Therapeutically effective blood concentrations are unclear so far, although there is evidence for minimal effective and upper-threshold concentrations that should not be exceeded. Paroxetine and, to a lesser degree, fluoxetine and norfluoxetine are potent inhibitors of CYP2D6 and fluvoxamine of CYP1A2 and CYP2C19. This can give rise to drug-drug interactions that may have no effect, lead to intoxication, or improve the therapeutic response. These different pharmacokinetic properties of the five SSRIs, especially their drug-drug interaction potential, should be considered when selecting a distinct SSRI for treatment of depression or other disorders with a suggested dysfunction of the serotonergic system in the brain." @default.
- W2090977130 created "2016-06-24" @default.
- W2090977130 creator A5007740742 @default.
- W2090977130 creator A5023011657 @default.
- W2090977130 date "2000-01-01" @default.
- W2090977130 modified "2023-10-14" @default.
- W2090977130 title "Pharmacokinetics of selective serotonin reuptake inhibitors" @default.
- W2090977130 cites W1482099441 @default.
- W2090977130 cites W1486692946 @default.
- W2090977130 cites W1520746198 @default.
- W2090977130 cites W1563566193 @default.
- W2090977130 cites W1563602211 @default.
- W2090977130 cites W1881287185 @default.
- W2090977130 cites W1966449565 @default.
- W2090977130 cites W1967389155 @default.
- W2090977130 cites W1968464659 @default.
- W2090977130 cites W1969143567 @default.
- W2090977130 cites W1969652902 @default.
- W2090977130 cites W1970387771 @default.
- W2090977130 cites W1970478660 @default.
- W2090977130 cites W1975377762 @default.
- W2090977130 cites W1976411805 @default.
- W2090977130 cites W1976469324 @default.
- W2090977130 cites W1977843945 @default.
- W2090977130 cites W1977911727 @default.
- W2090977130 cites W1978492748 @default.
- W2090977130 cites W1979452048 @default.
- W2090977130 cites W1980050671 @default.
- W2090977130 cites W1980149418 @default.
- W2090977130 cites W1980997291 @default.
- W2090977130 cites W1981038173 @default.
- W2090977130 cites W1981628559 @default.
- W2090977130 cites W1981743431 @default.
- W2090977130 cites W1984154961 @default.
- W2090977130 cites W1985261879 @default.
- W2090977130 cites W1986601193 @default.
- W2090977130 cites W1987434085 @default.
- W2090977130 cites W1989699877 @default.
- W2090977130 cites W1991887448 @default.
- W2090977130 cites W1993063613 @default.
- W2090977130 cites W1993858402 @default.
- W2090977130 cites W1994311873 @default.
- W2090977130 cites W1994328780 @default.
- W2090977130 cites W1995539988 @default.
- W2090977130 cites W1996049598 @default.
- W2090977130 cites W1996135092 @default.
- W2090977130 cites W1996673522 @default.
- W2090977130 cites W2002877208 @default.
- W2090977130 cites W2003059806 @default.
- W2090977130 cites W2003684988 @default.
- W2090977130 cites W2004018121 @default.
- W2090977130 cites W2006200390 @default.
- W2090977130 cites W2006998778 @default.
- W2090977130 cites W2007983159 @default.
- W2090977130 cites W2010258076 @default.
- W2090977130 cites W2011582509 @default.
- W2090977130 cites W2011759489 @default.
- W2090977130 cites W2012930672 @default.
- W2090977130 cites W2013587785 @default.
- W2090977130 cites W2013667225 @default.
- W2090977130 cites W2014163105 @default.
- W2090977130 cites W2014252886 @default.
- W2090977130 cites W2014972898 @default.
- W2090977130 cites W2015588335 @default.
- W2090977130 cites W2015632396 @default.
- W2090977130 cites W2016354756 @default.
- W2090977130 cites W2016637125 @default.
- W2090977130 cites W2016658800 @default.
- W2090977130 cites W2016911934 @default.
- W2090977130 cites W2020570228 @default.
- W2090977130 cites W2020944051 @default.
- W2090977130 cites W2023163409 @default.
- W2090977130 cites W2023198390 @default.
- W2090977130 cites W2025235181 @default.
- W2090977130 cites W2026266772 @default.
- W2090977130 cites W2029567501 @default.
- W2090977130 cites W2032884131 @default.
- W2090977130 cites W2033840482 @default.
- W2090977130 cites W2035351215 @default.
- W2090977130 cites W2037911192 @default.
- W2090977130 cites W2039289294 @default.
- W2090977130 cites W2039613541 @default.
- W2090977130 cites W2039848755 @default.
- W2090977130 cites W204060685 @default.
- W2090977130 cites W2040788916 @default.
- W2090977130 cites W2041472256 @default.
- W2090977130 cites W2044773067 @default.
- W2090977130 cites W2045654730 @default.
- W2090977130 cites W2045746023 @default.
- W2090977130 cites W2046615707 @default.
- W2090977130 cites W2047046946 @default.
- W2090977130 cites W2047526506 @default.
- W2090977130 cites W2048068577 @default.
- W2090977130 cites W2051143890 @default.
- W2090977130 cites W2052321118 @default.
- W2090977130 cites W2054061970 @default.
- W2090977130 cites W2055510932 @default.
- W2090977130 cites W2057522733 @default.