FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090977462> ?p ?o ?g. }

• W2090977462 endingPage "257" @default.
• W2090977462 startingPage "235" @default.
• W2090977462 abstract "The detailed anatomical distribution of iron in the post-mortem human brain has been studied using Perl’s and Turnbull’s methods with the diaminobenzidine intensification procedure for the demonstration of non-haem Fe³⁺ and Fe²⁺ respectively. Attention to methodological procedures has revealed that even brief immersion of tissue in routinely used fixatives causes a reduction of staining intensity in areas of high iron content and, often, loss of staining in areas of low iron content. Optimal staining is obtained using frozen section briefly fixed for 5 min in 4% formalin and Perl’s stain (Fe³⁺) with diaminobenzidine intensification. Highest levels of stainable iron were found in the extrapyramidal system with the globus pallidus, substantia nigra zona reticulata, red nucleus and myelinated fibres of the putamen showing highest staining reactivity. Moderate staining intensity with Perl’s technique was found in the majority of forebrain, midbrain and cerebellar structures with the striatum, thalamus, cortex and deep white matter, substantia nigra zona compacta, and cerebellar cortex showing consistent staining patterns with intensification of Perl’s stain. The brain-stem and spinal cord generally only showed staining with the intensification procedure and even this was of low intensity. Microscopically the non-heam iron appears to be found predominantly in glial cells as fine cytoplasmic granules which in heavily stained areas coalesce to fill the entire cell. Iron-positive granules appear to be free in the neuropil and also around blood vessels in the globus pallidus, striatum and substantia nigra. The neuropil shows a fibrous impregnation when stained for iron which is, in part, derived from glial processes, myelinated fibres and fibre bundles. Neurones, in general, show only very low reactivity for iron, and this is difficult to discern due, often, to the higher reactivity of the surrounding neuropil. In the globus pallidus and substantia nigra zona reticulata, neurones with highly stainable iron content are found with granular cytoplasmic iron reactivity similar to that seen in the local glial cells. Our results are comparable with those of early workers, but with the use of intensification extend the distribution of non-haem iron to areas previously reported as negative. No apparent correlation of iron staining with known neurotransmitter systems is seen and the predilection for the extrapyramidal system is not easily explained, though the non-haem iron in the brain appears to be as a storage form in the iron storage protein ferritin. The localization of iron in the brain provides a foundation for the study of iron in certain neurodegenerative diseases such as Parkinson’s disease, where iron has been implicated in the pathogenesis." @default.
• W2090977462 created "2016-06-24" @default.
• W2090977462 creator A5005111516 @default.
• W2090977462 creator A5018933278 @default.
• W2090977462 creator A5060926106 @default.
• W2090977462 creator A5075239227 @default.
• W2090977462 creator A5079660167 @default.
• W2090977462 date "1992-01-01" @default.
• W2090977462 modified "2023-10-11" @default.
• W2090977462 title "Histochemical Distribution of Non-Haem Iron in the Human Brain" @default.
• W2090977462 doi "https://doi.org/10.1159/000147312" @default.
• W2090977462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1529678" @default.
• W2090977462 hasPublicationYear "1992" @default.
• W2090977462 type Work @default.
• W2090977462 sameAs 2090977462 @default.
• W2090977462 citedByCount "198" @default.
• W2090977462 countsByYear W20909774622012 @default.
• W2090977462 countsByYear W20909774622013 @default.
• W2090977462 countsByYear W20909774622014 @default.
• W2090977462 countsByYear W20909774622015 @default.
• W2090977462 countsByYear W20909774622016 @default.
• W2090977462 countsByYear W20909774622017 @default.
• W2090977462 countsByYear W20909774622018 @default.
• W2090977462 countsByYear W20909774622019 @default.
• W2090977462 countsByYear W20909774622020 @default.
• W2090977462 countsByYear W20909774622021 @default.
• W2090977462 countsByYear W20909774622022 @default.
• W2090977462 countsByYear W20909774622023 @default.
• W2090977462 crossrefType "journal-article" @default.
• W2090977462 hasAuthorship W2090977462A5005111516 @default.
• W2090977462 hasAuthorship W2090977462A5018933278 @default.
• W2090977462 hasAuthorship W2090977462A5060926106 @default.
• W2090977462 hasAuthorship W2090977462A5075239227 @default.
• W2090977462 hasAuthorship W2090977462A5079660167 @default.
• W2090977462 hasConcept C105702510 @default.
• W2090977462 hasConcept C137183658 @default.
• W2090977462 hasConcept C142724271 @default.
• W2090977462 hasConcept C169760540 @default.
• W2090977462 hasConcept C185592680 @default.
• W2090977462 hasConcept C2776773494 @default.
• W2090977462 hasConcept C2777831001 @default.
• W2090977462 hasConcept C2778187257 @default.
• W2090977462 hasConcept C2779384463 @default.
• W2090977462 hasConcept C2779920484 @default.
• W2090977462 hasConcept C2780062018 @default.
• W2090977462 hasConcept C2780278869 @default.
• W2090977462 hasConcept C2780723820 @default.
• W2090977462 hasConcept C2780938664 @default.
• W2090977462 hasConcept C2781294515 @default.
• W2090977462 hasConcept C43310041 @default.
• W2090977462 hasConcept C513476851 @default.
• W2090977462 hasConcept C529278444 @default.
• W2090977462 hasConcept C71924100 @default.
• W2090977462 hasConcept C74864618 @default.
• W2090977462 hasConcept C86803240 @default.
• W2090977462 hasConceptScore W2090977462C105702510 @default.
• W2090977462 hasConceptScore W2090977462C137183658 @default.
• W2090977462 hasConceptScore W2090977462C142724271 @default.
• W2090977462 hasConceptScore W2090977462C169760540 @default.
• W2090977462 hasConceptScore W2090977462C185592680 @default.
• W2090977462 hasConceptScore W2090977462C2776773494 @default.
• W2090977462 hasConceptScore W2090977462C2777831001 @default.
• W2090977462 hasConceptScore W2090977462C2778187257 @default.
• W2090977462 hasConceptScore W2090977462C2779384463 @default.
• W2090977462 hasConceptScore W2090977462C2779920484 @default.
• W2090977462 hasConceptScore W2090977462C2780062018 @default.
• W2090977462 hasConceptScore W2090977462C2780278869 @default.
• W2090977462 hasConceptScore W2090977462C2780723820 @default.
• W2090977462 hasConceptScore W2090977462C2780938664 @default.
• W2090977462 hasConceptScore W2090977462C2781294515 @default.
• W2090977462 hasConceptScore W2090977462C43310041 @default.
• W2090977462 hasConceptScore W2090977462C513476851 @default.
• W2090977462 hasConceptScore W2090977462C529278444 @default.
• W2090977462 hasConceptScore W2090977462C71924100 @default.
• W2090977462 hasConceptScore W2090977462C74864618 @default.
• W2090977462 hasConceptScore W2090977462C86803240 @default.
• W2090977462 hasIssue "3" @default.
• W2090977462 hasLocation W20909774621 @default.
• W2090977462 hasLocation W20909774622 @default.
• W2090977462 hasOpenAccess W2090977462 @default.
• W2090977462 hasPrimaryLocation W20909774621 @default.
• W2090977462 hasRelatedWork W2073396373 @default.
• W2090977462 hasRelatedWork W2086361121 @default.
• W2090977462 hasRelatedWork W2564110825 @default.
• W2090977462 hasRelatedWork W2898132477 @default.
• W2090977462 hasRelatedWork W2900464582 @default.
• W2090977462 hasRelatedWork W2903786868 @default.
• W2090977462 hasRelatedWork W3049065873 @default.
• W2090977462 hasRelatedWork W3198631704 @default.
• W2090977462 hasRelatedWork W4308637479 @default.
• W2090977462 hasRelatedWork W1654412445 @default.
• W2090977462 hasVolume "144" @default.
• W2090977462 isParatext "false" @default.
• W2090977462 isRetracted "false" @default.
• W2090977462 magId "2090977462" @default.
• W2090977462 workType "article" @default.