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- W2090981404 abstract "The anatomical distribution and pharmacology of serotonin 6 receptors (5-HT6Rs) implicate them as contributors to the serotonergic regulation of complex behavior. To complement the limited range of pharmacological tools available to examine 5-HT6R function, we have generated a mouse line bearing a constitutive null mutation of the 5-HT6R gene. No perturbations of baseline behavior were noted in a wide array of assays pertinent to multiple neurobehavioral processes. However, 5-HT6R mutant mice demonstrated reduced responses to the ataxic and sedative effects of ethanol. No differences in ethanol metabolism were evident between wild-type and 5-HT6R mutant mice. These findings implicate 5-HT6Rs in the serotonergic modulation of responses to ethanol." @default.
- W2090981404 created "2016-06-24" @default.
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- W2090981404 date "2006-02-01" @default.
- W2090981404 modified "2023-10-13" @default.
- W2090981404 title "A Null Mutation of the Serotonin 6 Receptor Alters Acute Responses to Ethanol" @default.
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- W2090981404 doi "https://doi.org/10.1038/sj.npp.1301030" @default.
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