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• W2090981990 startingPage "84" @default.
• W2090981990 abstract "In acutely isolated spinal dorsal horn neurons of the rat, effects of serotonin (5-hydroxytryptamine, 5-HT) on inward current induced by excitatory amino acids were studied under whole-cell voltage-clamp condition. 5-HT suppressed the response toN-methyl-d-aspartate (NMDA), but not the response to kainate or quisqualate. This inhibitory effect of 5-HT on NMDA response was present at 5-HT concentrations as low as 10−15 M. Although the 5-HT effect exhibited similar pharmacology to the 5-HT1A-type receptors, it was not mimicked by increasing intracellular concentration of adenosine 3′,5′-cyclic monophosphate that is the common second messenger for 5-HT1A receptors in the mammalian central nervous system. Glycine strongly antagonized this inhibitory effect of 5-HT, and 5-HT reduced opening of NMDA-gated single channels recorded from the outside-out membrane patch. These lines of evidence are consistent with a possibility that 5-HT might directly modulate the NMDA receptor-ion channel complex, either by interacting with the regulatory site(s) or by acting on a distinct site." @default.
• W2090981990 created "2016-06-24" @default.
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• W2090981990 date "1990-08-01" @default.
• W2090981990 modified "2023-09-28" @default.
• W2090981990 title "Serotonin suppressesN-methyl-d-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat" @default.
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• W2090981990 doi "https://doi.org/10.1016/0006-8993(90)91323-9" @default.
• W2090981990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2147117" @default.
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