FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090984766> ?p ?o ?g. }

• W2090984766 endingPage "2999" @default.
• W2090984766 startingPage "2993" @default.
• W2090984766 abstract "During cognate B : T interactions, B cells encounter antigen (Ag) through surface immuno-globulin (sIg) and present antigenic peptides to T helper (Th) cells. However, most in vitro systems used to study contact events involved in the delivery of T help for B cells circumvent the requirement for T cell Ag specificity by using anti-CD3/T cell receptor (TcR) monoclonal antibodies (mAb) to activate T cells. To study the role of sIg engagement in the responsiveness of B cells to T help, we pre-treated small resting B cells with soluble anti-χ mAb prior to contact with an activated Th1 clone. By reducing the concentration of anti-TcR mAb we obtained low levels of CD40 ligand (CD40Llow) on Th cells, comparable to those expressed by lymph node T cells activated in vitro (ex vivo T cells). In contrast to untreated B cells, which did not respond to CD40Llow Th, anti-Ig-treated B cells responded strongly. Low buoyant density B cells also responded to CD40Llow Th cells. There was no B cell response to resting Th cells. mAb against CD54/intercellular adhesion molecule-1 or major histocompatibility complex (MHC) class II completely inhibited B cell responses to CD40Llow Th1 cells, equivalent to the effects of blocking CD40 interactions. This contrasts with mAb blocking responses to CD40LhighTh, where CD40 effects predominate. Our data show that sIg engagement is necessary for the induction of B cell response to CD40Llow Th cells. Anti-CD3-activated ex vivo T cells that were also CD40Llow did not provide help to small resting B cells, but did induce responses from sIg-stimulated B cells. Thus, our data support a requirement for sIg signaling in physiological B cell activation, and further confirm previous work showing CD40 ligation to be necessary but not sufficient for delivery of T help to B cells." @default.
• W2090984766 created "2016-06-24" @default.
• W2090984766 creator A5054164188 @default.
• W2090984766 creator A5066957493 @default.
• W2090984766 date "1994-12-01" @default.
• W2090984766 modified "2023-10-18" @default.
• W2090984766 title "Co-stimulation by anti-immunoglobulin is required for B cell activation by CD40Llow T cells" @default.
• W2090984766 cites W1489363586 @default.
• W2090984766 cites W1489445407 @default.
• W2090984766 cites W1490721606 @default.
• W2090984766 cites W1535001238 @default.
• W2090984766 cites W1569106121 @default.
• W2090984766 cites W1577755598 @default.
• W2090984766 cites W1585428065 @default.
• W2090984766 cites W1621680685 @default.
• W2090984766 cites W1642708427 @default.
• W2090984766 cites W1656028626 @default.
• W2090984766 cites W1851325672 @default.
• W2090984766 cites W1858773643 @default.
• W2090984766 cites W1917800718 @default.
• W2090984766 cites W1920561703 @default.
• W2090984766 cites W1969293902 @default.
• W2090984766 cites W1978790143 @default.
• W2090984766 cites W1983795855 @default.
• W2090984766 cites W1987968095 @default.
• W2090984766 cites W1988087702 @default.
• W2090984766 cites W1989305940 @default.
• W2090984766 cites W1990435078 @default.
• W2090984766 cites W1992298829 @default.
• W2090984766 cites W2007289040 @default.
• W2090984766 cites W2008636680 @default.
• W2090984766 cites W2013278989 @default.
• W2090984766 cites W2018202144 @default.
• W2090984766 cites W2018416540 @default.
• W2090984766 cites W2019454556 @default.
• W2090984766 cites W2028411896 @default.
• W2090984766 cites W2028862502 @default.
• W2090984766 cites W2032626982 @default.
• W2090984766 cites W2036341381 @default.
• W2090984766 cites W2037244730 @default.
• W2090984766 cites W2042043269 @default.
• W2090984766 cites W2043606640 @default.
• W2090984766 cites W2047075585 @default.
• W2090984766 cites W2060382742 @default.
• W2090984766 cites W2060452488 @default.
• W2090984766 cites W2061851661 @default.
• W2090984766 cites W2062940475 @default.
• W2090984766 cites W2067568912 @default.
• W2090984766 cites W2070379407 @default.
• W2090984766 cites W2076820280 @default.
• W2090984766 cites W2081070214 @default.
• W2090984766 cites W2084136953 @default.
• W2090984766 cites W2085228104 @default.
• W2090984766 cites W2087013294 @default.
• W2090984766 cites W2088955069 @default.
• W2090984766 cites W2095408546 @default.
• W2090984766 cites W2098123605 @default.
• W2090984766 cites W2102572112 @default.
• W2090984766 cites W2111344966 @default.
• W2090984766 cites W2127529545 @default.
• W2090984766 cites W2131721083 @default.
• W2090984766 cites W2139458081 @default.
• W2090984766 cites W2147715156 @default.
• W2090984766 cites W2176563609 @default.
• W2090984766 cites W4210866193 @default.
• W2090984766 cites W51465864 @default.
• W2090984766 doi "https://doi.org/10.1002/eji.1830241211" @default.
• W2090984766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7805727" @default.
• W2090984766 hasPublicationYear "1994" @default.
• W2090984766 type Work @default.
• W2090984766 sameAs 2090984766 @default.
• W2090984766 citedByCount "21" @default.
• W2090984766 countsByYear W20909847662013 @default.
• W2090984766 countsByYear W20909847662015 @default.
• W2090984766 countsByYear W20909847662019 @default.
• W2090984766 crossrefType "journal-article" @default.
• W2090984766 hasAuthorship W2090984766A5054164188 @default.
• W2090984766 hasAuthorship W2090984766A5066957493 @default.
• W2090984766 hasConcept C129374314 @default.
• W2090984766 hasConcept C147483822 @default.
• W2090984766 hasConcept C153911025 @default.
• W2090984766 hasConcept C154317977 @default.
• W2090984766 hasConcept C157695867 @default.
• W2090984766 hasConcept C159654299 @default.
• W2090984766 hasConcept C200180986 @default.
• W2090984766 hasConcept C202751555 @default.
• W2090984766 hasConcept C203014093 @default.
• W2090984766 hasConcept C207936829 @default.
• W2090984766 hasConcept C2776090121 @default.
• W2090984766 hasConcept C2778453870 @default.
• W2090984766 hasConcept C39347974 @default.
• W2090984766 hasConcept C552990157 @default.
• W2090984766 hasConcept C55493867 @default.
• W2090984766 hasConcept C67662055 @default.
• W2090984766 hasConcept C81089528 @default.
• W2090984766 hasConcept C86803240 @default.
• W2090984766 hasConcept C8891405 @default.
• W2090984766 hasConcept C95444343 @default.

• next