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- W2090988932 abstract "Background An unprecedented effort from public and private international health agencies has been made to address the urgent issue of malaria in pregnancy. The selection of antimalarial drug therapy during pregnancy currently depends upon the severity of the disease, gestational age (stage of fetal development) and patterns of drug resistance in the area. To combat multi-drug resistance the WHO recommends include the use of Artemisinin-based combination therapies. To assist in policy formulation of arteminisin drug combination therapy during pregnancy, artemisinin-derivatives are currently undergoing pre¬clinical risk:benefit assessments [1]. Recent animal trials have indicated that arteminisins during pregnancy result in fetal morbidity, low birthweight, cardiac and skeletal birth defects [2]. Currently validated preclinical teratogenicity/embryolethality drug screen¬ing includes whole embryo culture (WEC), Micromass (MM) limb bud and embryonic stem cell (ESC) culture together with in vivo studies to assess embryonic development [3,4]. However while in vivo screening assays to gestational day (GD) 13+ enable unambiguous assessment of artemisinin-associated embryotoxicity, standard in vitro 48hr WEC studies from 9-11 GD end before the teratogenic effects on vulnerable organ systems impacted by the drug can be evaluated. To address this problem, the WEC experiment is extended to 72 hours: after vascular and limb bud development." @default.
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- W2090988932 date "2010-10-20" @default.
- W2090988932 modified "2023-10-13" @default.
- W2090988932 title "Advancements in preclinical screening methods for artemisinins during pregnancy" @default.
- W2090988932 cites W2012487690 @default.
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- W2090988932 doi "https://doi.org/10.1186/1475-2875-9-s2-p8" @default.
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