FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090989843> ?p ?o ?g. }

• W2090989843 endingPage "1072" @default.
• W2090989843 startingPage "1067" @default.
• W2090989843 abstract "Patients with fulminant hepatic failure (FHF) have a severe microcirculatory disturbance causing tissue hypoxia. Infusion of acetylcysteine improves survival and reduces the incidence of multiorgan failure by enhancing tissue oxygenation. Because the observed circulatory effects of acetylcysteine in FHF are similar to and synergistic with those produced by the microcirculatory vasodilator prostacyclin, we postulated that acetylcysteine might potentiate an endogenous vasodilator. Nitric oxide, a vasodilator that activates soluble guanylate cyclase, is a possible candidate as plasma cyclic 3',5'-guanosine monophosphate (cGMP) is raised in FHF, and in vitro acetylcysteine has been found to enhance soluble guanylate cyclase activity. To investigate this possible mechanism further, plasma cGMP was measured before and after acetylcysteine infusion in 24 patients with FHF and again in 6 patients after recovery from acute illness. cGMP levels were high in FHF during acute illness (median, 7.0 nmol/L [interquartile range, 2.6-10.0]) in comparison with levels taken after recovery (1.5 nmol/L [1.0-1.9]; P < .05). Levels rose further after acetylcysteine infusion in the FHF cases (mean increase, 204% [95% CI; 49 to +360]; P < .01) but not in the cases after recovery (38% [-7 to +84]). There were no significant changes in levels of plasma atrial natriuretic peptide (ANP) or cyclic adenosine monophosphate (cAMP) (mean increases, 8% [-6 to +22] and 17% [-9 to +43], respectively). The findings further support the hypothesis that the beneficial hemodynamic effects of acetylcysteine in FHF are mediated by enhancing the activity of the nitric oxide/soluble guanylate cyclase enzyme system." @default.
• W2090989843 created "2016-06-24" @default.
• W2090989843 creator A5009574999 @default.
• W2090989843 creator A5033168111 @default.
• W2090989843 creator A5085011088 @default.
• W2090989843 date "1996-05-01" @default.
• W2090989843 modified "2023-10-02" @default.
• W2090989843 title "Evidence of increased guanylate cyclase activation by acetylcysteine in fulminant hepatic failure" @default.
• W2090989843 cites W1512367461 @default.
• W2090989843 cites W1517162073 @default.
• W2090989843 cites W1546658436 @default.
• W2090989843 cites W1560458120 @default.
• W2090989843 cites W1608208977 @default.
• W2090989843 cites W1838917319 @default.
• W2090989843 cites W1922225321 @default.
• W2090989843 cites W1929009802 @default.
• W2090989843 cites W1946927438 @default.
• W2090989843 cites W1968688007 @default.
• W2090989843 cites W1973294684 @default.
• W2090989843 cites W1992340941 @default.
• W2090989843 cites W1998433395 @default.
• W2090989843 cites W2000075945 @default.
• W2090989843 cites W2002192155 @default.
• W2090989843 cites W2006461547 @default.
• W2090989843 cites W2007737411 @default.
• W2090989843 cites W2009784881 @default.
• W2090989843 cites W2019499720 @default.
• W2090989843 cites W2022140790 @default.
• W2090989843 cites W2040852689 @default.
• W2090989843 cites W2048635427 @default.
• W2090989843 cites W2062363486 @default.
• W2090989843 cites W2072785177 @default.
• W2090989843 cites W2074236325 @default.
• W2090989843 cites W2081219459 @default.
• W2090989843 cites W2081503515 @default.
• W2090989843 cites W2085873720 @default.
• W2090989843 cites W2087522321 @default.
• W2090989843 cites W2092643965 @default.
• W2090989843 cites W2093518775 @default.
• W2090989843 cites W2113846740 @default.
• W2090989843 cites W2114758608 @default.
• W2090989843 cites W2116723311 @default.
• W2090989843 cites W2125422424 @default.
• W2090989843 cites W2159790292 @default.
• W2090989843 cites W2160749102 @default.
• W2090989843 cites W2313265919 @default.
• W2090989843 cites W2411266880 @default.
• W2090989843 cites W2412242234 @default.
• W2090989843 cites W2415856156 @default.
• W2090989843 doi "https://doi.org/10.1053/jhep.1996.v23.pm0008621135" @default.
• W2090989843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8621135" @default.
• W2090989843 hasPublicationYear "1996" @default.
• W2090989843 type Work @default.
• W2090989843 sameAs 2090989843 @default.
• W2090989843 citedByCount "30" @default.
• W2090989843 countsByYear W20909898432013 @default.
• W2090989843 countsByYear W20909898432015 @default.
• W2090989843 countsByYear W20909898432017 @default.
• W2090989843 countsByYear W20909898432018 @default.
• W2090989843 countsByYear W20909898432019 @default.
• W2090989843 countsByYear W20909898432020 @default.
• W2090989843 countsByYear W20909898432021 @default.
• W2090989843 countsByYear W20909898432022 @default.
• W2090989843 countsByYear W20909898432023 @default.
• W2090989843 crossrefType "journal-article" @default.
• W2090989843 hasAuthorship W2090989843A5009574999 @default.
• W2090989843 hasAuthorship W2090989843A5033168111 @default.
• W2090989843 hasAuthorship W2090989843A5085011088 @default.
• W2090989843 hasConcept C120770815 @default.
• W2090989843 hasConcept C126322002 @default.
• W2090989843 hasConcept C134018914 @default.
• W2090989843 hasConcept C185592680 @default.
• W2090989843 hasConcept C2777847592 @default.
• W2090989843 hasConcept C2778004101 @default.
• W2090989843 hasConcept C2778069365 @default.
• W2090989843 hasConcept C2779609443 @default.
• W2090989843 hasConcept C2780994212 @default.
• W2090989843 hasConcept C2911091166 @default.
• W2090989843 hasConcept C2911118192 @default.
• W2090989843 hasConcept C519581460 @default.
• W2090989843 hasConcept C55493867 @default.
• W2090989843 hasConcept C71924100 @default.
• W2090989843 hasConcept C98274493 @default.
• W2090989843 hasConceptScore W2090989843C120770815 @default.
• W2090989843 hasConceptScore W2090989843C126322002 @default.
• W2090989843 hasConceptScore W2090989843C134018914 @default.
• W2090989843 hasConceptScore W2090989843C185592680 @default.
• W2090989843 hasConceptScore W2090989843C2777847592 @default.
• W2090989843 hasConceptScore W2090989843C2778004101 @default.
• W2090989843 hasConceptScore W2090989843C2778069365 @default.
• W2090989843 hasConceptScore W2090989843C2779609443 @default.
• W2090989843 hasConceptScore W2090989843C2780994212 @default.
• W2090989843 hasConceptScore W2090989843C2911091166 @default.
• W2090989843 hasConceptScore W2090989843C2911118192 @default.
• W2090989843 hasConceptScore W2090989843C519581460 @default.
• W2090989843 hasConceptScore W2090989843C55493867 @default.
• W2090989843 hasConceptScore W2090989843C71924100 @default.
• W2090989843 hasConceptScore W2090989843C98274493 @default.

• next