FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090996688> ?p ?o ?g. }

• W2090996688 endingPage "3330" @default.
• W2090996688 startingPage "3321" @default.
• W2090996688 abstract "Abstract Natural killer (NK) cells are classically viewed as effector cells that kill virus-infected and neoplastic cells, but recent studies have identified a rare mucosal NK- cell subpopulation secreting the TH17 cytokine IL-22. Here, we report identification of 2 distinct lineages of mucosal NK cells characterized as NKG2A+NFIL3+RORC– and NKp44+NFIL3+RORC+. NKG2A+ NK cells were systemically distributed, cytotoxic, and secreted IFN-γ, whereas NKp44+ NK cells were mucosae-restricted, noncytotoxic, and produced IL-22 and IL-17. During SIV infection, NKp44+ NK cells became apoptotic, were depleted, and had an altered functional profile characterized by decreased IL-17 secretion; increased IFN-γ secretion; and, surprisingly, increased potential for cytotoxicity. NKp44+ NK cells showed no evidence of direct SIV infection; rather, depletion and altered function were associated with SIV-induced up-regulation of inflammatory mediators in the gut, including indoleamine 2,3-dioxygenase 1. Furthermore, treatment of NKp44+ NK cells with indoleamine 2,3-dioxygenase 1 catabolites in vitro ablated IL-17 production in a dose-dependent manner, whereas other NK-cell functions were unaffected. Thus lentiviral infection both depletes and modifies the functional repertoire of mucosal NK cells involved in the maintenance of gut integrity, a finding that highlights the plasticity of this rare mucosal NK-cell population." @default.
• W2090996688 created "2016-06-24" @default.
• W2090996688 creator A5008690825 @default.
• W2090996688 creator A5015756567 @default.
• W2090996688 creator A5027674113 @default.
• W2090996688 creator A5032591412 @default.
• W2090996688 creator A5045177597 @default.
• W2090996688 creator A5054928376 @default.
• W2090996688 creator A5070133821 @default.
• W2090996688 creator A5080176083 @default.
• W2090996688 creator A5081270490 @default.
• W2090996688 date "2011-09-22" @default.
• W2090996688 modified "2023-10-14" @default.
• W2090996688 title "Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection" @default.
• W2090996688 cites W1574804491 @default.
• W2090996688 cites W1579108180 @default.
• W2090996688 cites W1607475798 @default.
• W2090996688 cites W1965031244 @default.
• W2090996688 cites W1965696330 @default.
• W2090996688 cites W1976790296 @default.
• W2090996688 cites W1981459523 @default.
• W2090996688 cites W1982840915 @default.
• W2090996688 cites W1983291180 @default.
• W2090996688 cites W1983996935 @default.
• W2090996688 cites W1989733573 @default.
• W2090996688 cites W1994216243 @default.
• W2090996688 cites W1996770717 @default.
• W2090996688 cites W1997849135 @default.
• W2090996688 cites W1999022079 @default.
• W2090996688 cites W2006711580 @default.
• W2090996688 cites W2011017810 @default.
• W2090996688 cites W2014437975 @default.
• W2090996688 cites W2026340875 @default.
• W2090996688 cites W2027822830 @default.
• W2090996688 cites W2034931711 @default.
• W2090996688 cites W2036505093 @default.
• W2090996688 cites W2038733892 @default.
• W2090996688 cites W2043437568 @default.
• W2090996688 cites W2045906638 @default.
• W2090996688 cites W2049504854 @default.
• W2090996688 cites W2058321555 @default.
• W2090996688 cites W2058408338 @default.
• W2090996688 cites W2059801006 @default.
• W2090996688 cites W2061027627 @default.
• W2090996688 cites W2065958240 @default.
• W2090996688 cites W2066532177 @default.
• W2090996688 cites W2067885308 @default.
• W2090996688 cites W2074067501 @default.
• W2090996688 cites W2078489697 @default.
• W2090996688 cites W2081441708 @default.
• W2090996688 cites W2084387136 @default.
• W2090996688 cites W2095603321 @default.
• W2090996688 cites W2113417184 @default.
• W2090996688 cites W2114665853 @default.
• W2090996688 cites W2116289946 @default.
• W2090996688 cites W2128306333 @default.
• W2090996688 cites W2132130088 @default.
• W2090996688 cites W2132547595 @default.
• W2090996688 cites W2138637758 @default.
• W2090996688 cites W2150012893 @default.
• W2090996688 cites W2155997615 @default.
• W2090996688 cites W2772222670 @default.
• W2090996688 cites W4256153855 @default.
• W2090996688 cites W4298176974 @default.
• W2090996688 doi "https://doi.org/10.1182/blood-2011-04-347260" @default.
• W2090996688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3179400" @default.
• W2090996688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21791421" @default.
• W2090996688 hasPublicationYear "2011" @default.
• W2090996688 type Work @default.
• W2090996688 sameAs 2090996688 @default.
• W2090996688 citedByCount "94" @default.
• W2090996688 countsByYear W20909966882012 @default.
• W2090996688 countsByYear W20909966882013 @default.
• W2090996688 countsByYear W20909966882014 @default.
• W2090996688 countsByYear W20909966882015 @default.
• W2090996688 countsByYear W20909966882016 @default.
• W2090996688 countsByYear W20909966882017 @default.
• W2090996688 countsByYear W20909966882018 @default.
• W2090996688 countsByYear W20909966882019 @default.
• W2090996688 countsByYear W20909966882020 @default.
• W2090996688 countsByYear W20909966882021 @default.
• W2090996688 countsByYear W20909966882022 @default.
• W2090996688 countsByYear W20909966882023 @default.
• W2090996688 crossrefType "journal-article" @default.
• W2090996688 hasAuthorship W2090996688A5008690825 @default.
• W2090996688 hasAuthorship W2090996688A5015756567 @default.
• W2090996688 hasAuthorship W2090996688A5027674113 @default.
• W2090996688 hasAuthorship W2090996688A5032591412 @default.
• W2090996688 hasAuthorship W2090996688A5045177597 @default.
• W2090996688 hasAuthorship W2090996688A5054928376 @default.
• W2090996688 hasAuthorship W2090996688A5070133821 @default.
• W2090996688 hasAuthorship W2090996688A5080176083 @default.
• W2090996688 hasAuthorship W2090996688A5081270490 @default.
• W2090996688 hasBestOaLocation W20909966882 @default.
• W2090996688 hasConcept C129374314 @default.
• W2090996688 hasConcept C149532602 @default.
• W2090996688 hasConcept C154317977 @default.
• W2090996688 hasConcept C202751555 @default.

• next