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- W2090996826 abstract "Cisapride as a prokinetic drug inhibits rapid delayed rectifier potassium channel current. As producing QT interval prolongation and causes fatal cardiac arrhythmias, it has been withdrawn from clinical uses. However, exact mechanisms for the proarrhythmic effects of cisapride are incompletely unclear. In this study, we implemented a biophysically detailed computational model of the heart to quantify the effects of the cisapride on cardiac electrical activities at cellular and tissue levels, from which we analyzed the proarrhythmic effects of the agent." @default.
- W2090996826 created "2016-06-24" @default.
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- W2090996826 date "2014-11-01" @default.
- W2090996826 modified "2023-09-25" @default.
- W2090996826 title "Proarrhythmic effects of cisapride: Insights from a simulation study" @default.
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- W2090996826 doi "https://doi.org/10.1109/bibm.2014.6999258" @default.
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