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- W2090996835 abstract "Chronic post-surgical pain is a common, under-recognized and important clinical problem which affects millions of patients worldwide. It results from a series of neuroplastic changes associated most commonly with peripheral nerve injury at the time of surgery. Predisposing factors include the type of surgery, pre-operative and acute post-operative pain intensity, and probably psychological (e.g. pain-catastrophizing) and genetic factors [e.g. GCH1 (GTP cyclohydrolase 1) haplotype]. Preventive measures which are currently available include selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. Very promising therapeutic agents which target the sensitization process are currently in development." @default.
- W2090996835 created "2016-06-24" @default.
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- W2090996835 date "2009-01-20" @default.
- W2090996835 modified "2023-09-25" @default.
- W2090996835 title "When pain after surgery doesn't go away…" @default.
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- W2090996835 doi "https://doi.org/10.1042/bst0370318" @default.
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