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• W2091004022 abstract "Background: Cells producing a Th2 -cytokine profile play an important role in the onset and maintenance of atopic diseases, and therefore specific immunotherapy is aimed to induce a switch to cells producing a Th1 - or Th0 -cytokine profile. Recently, a novel form of immunotherapy making use of synthetic peptides from the major cat allergen Fel d 1 has been developed, but its mechanisms of action are unknown. Objectives: We examined the effects of immunotherapy with Fel d 1 peptides on the response to bronchial provocation tests (PD20 FEV1 ) with a standardized Fel d 1 cat extract on Fel d 1–specific serum IgE and IgG levels and in vitro IL-4 and IFN-γ production. Methods: Patients allergic to cats received 6 weekly injections of 7.5 μg (low dose), 75 μg (medium dose), or 750 μg (high dose) of Fel d 1 peptides (25 patients) or a placebo (6 patients). Results: Six weeks after ending immunotherapy, posttreatment PD20 FEV1 was not significantly different between the treated and placebo groups. However, in the medium- and high-dose groups there was a significant improvement between baseline and posttreatment days. IL-4 release was significantly reduced in the high dose–treated group (P < .005, Wilcoxon W test), whereas it was unchanged in the low or medium dose– and in the placebo-treated groups. In all groups, IFN-γ, IgE, and IgG levels remained unchanged. Conclusion: There was no correlation between the improvement of PD20 FEV1 and the decrease in IL-4 production. These data suggest that peptide immunotherapy may act by shifting the Fel d 1–induced response of PBMCs in vitro from the Th2 -like to the Th0 -like phenotype. (J Allergy Clin Immunol 1998;102:571-8.)" @default.
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• W2091004022 date "1998-10-01" @default.
• W2091004022 modified "2023-09-23" @default.
• W2091004022 title "Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats☆☆☆★★★" @default.
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• W2091004022 doi "https://doi.org/10.1016/s0091-6749(98)70294-5" @default.
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