FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091010250> ?p ?o ?g. }

• W2091010250 endingPage "7974" @default.
• W2091010250 startingPage "7968" @default.
• W2091010250 abstract "A series of CC chemokine receptor-4 (CCR4) antagonists were examined in a previous report in an attempt to improve metabolic stability in human liver microsomes. In this study, the cycloheptylamine moiety of N-cycloheptyl-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine 1 was replaced with the p-chloroaniline moiety, and the resulting compound, N-(4-chlorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine (8c), retained its potency ([(35)S]GTPgammaS-binding inhibition and CCL22-induced chemotaxis in humans/mice). Based on the structure-activity relationships (SAR), a homology model was constructed for CCR4 to explain the binding mode of 8c. Overall, there was good agreement between the docking pose of the CCR4 homology model and the human [(35)S]GTPgammaS assay results. Administration of 8c in a murine model of acute dermatitis showed anti-inflammatory activity (oxazolone-induced contact hypersensitivity test)." @default.
• W2091010250 created "2016-06-24" @default.
• W2091010250 creator A5002635958 @default.
• W2091010250 creator A5004995487 @default.
• W2091010250 creator A5007156487 @default.
• W2091010250 creator A5022925910 @default.
• W2091010250 creator A5028451977 @default.
• W2091010250 creator A5036387418 @default.
• W2091010250 creator A5045464406 @default.
• W2091010250 creator A5047394482 @default.
• W2091010250 creator A5053498181 @default.
• W2091010250 creator A5061551238 @default.
• W2091010250 creator A5062991341 @default.
• W2091010250 creator A5067981916 @default.
• W2091010250 date "2008-09-01" @default.
• W2091010250 modified "2023-09-24" @default.
• W2091010250 title "Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolines" @default.
• W2091010250 cites W1552117335 @default.
• W2091010250 cites W1973191530 @default.
• W2091010250 cites W1976905332 @default.
• W2091010250 cites W1978201079 @default.
• W2091010250 cites W1984857093 @default.
• W2091010250 cites W2016317210 @default.
• W2091010250 cites W2035093405 @default.
• W2091010250 cites W2038610464 @default.
• W2091010250 cites W2041161248 @default.
• W2091010250 cites W2051019755 @default.
• W2091010250 cites W2063001043 @default.
• W2091010250 cites W2082086413 @default.
• W2091010250 cites W2095245907 @default.
• W2091010250 cites W2101436464 @default.
• W2091010250 cites W2103384599 @default.
• W2091010250 cites W2117228071 @default.
• W2091010250 cites W2118526748 @default.
• W2091010250 cites W2149963584 @default.
• W2091010250 cites W2154685907 @default.
• W2091010250 cites W2160129587 @default.
• W2091010250 cites W2161167143 @default.
• W2091010250 cites W97158386 @default.
• W2091010250 doi "https://doi.org/10.1016/j.bmc.2008.07.062" @default.
• W2091010250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18694645" @default.
• W2091010250 hasPublicationYear "2008" @default.
• W2091010250 type Work @default.
• W2091010250 sameAs 2091010250 @default.
• W2091010250 citedByCount "23" @default.
• W2091010250 countsByYear W20910102502012 @default.
• W2091010250 countsByYear W20910102502013 @default.
• W2091010250 countsByYear W20910102502014 @default.
• W2091010250 countsByYear W20910102502015 @default.
• W2091010250 countsByYear W20910102502016 @default.
• W2091010250 countsByYear W20910102502017 @default.
• W2091010250 countsByYear W20910102502019 @default.
• W2091010250 countsByYear W20910102502020 @default.
• W2091010250 countsByYear W20910102502022 @default.
• W2091010250 crossrefType "journal-article" @default.
• W2091010250 hasAuthorship W2091010250A5002635958 @default.
• W2091010250 hasAuthorship W2091010250A5004995487 @default.
• W2091010250 hasAuthorship W2091010250A5007156487 @default.
• W2091010250 hasAuthorship W2091010250A5022925910 @default.
• W2091010250 hasAuthorship W2091010250A5028451977 @default.
• W2091010250 hasAuthorship W2091010250A5036387418 @default.
• W2091010250 hasAuthorship W2091010250A5045464406 @default.
• W2091010250 hasAuthorship W2091010250A5047394482 @default.
• W2091010250 hasAuthorship W2091010250A5053498181 @default.
• W2091010250 hasAuthorship W2091010250A5061551238 @default.
• W2091010250 hasAuthorship W2091010250A5062991341 @default.
• W2091010250 hasAuthorship W2091010250A5067981916 @default.
• W2091010250 hasConcept C159110408 @default.
• W2091010250 hasConcept C169627665 @default.
• W2091010250 hasConcept C170493617 @default.
• W2091010250 hasConcept C181199279 @default.
• W2091010250 hasConcept C185592680 @default.
• W2091010250 hasConcept C193042331 @default.
• W2091010250 hasConcept C202751555 @default.
• W2091010250 hasConcept C2776568683 @default.
• W2091010250 hasConcept C2778684643 @default.
• W2091010250 hasConcept C2778938600 @default.
• W2091010250 hasConcept C41685203 @default.
• W2091010250 hasConcept C55493867 @default.
• W2091010250 hasConcept C57992300 @default.
• W2091010250 hasConcept C71240020 @default.
• W2091010250 hasConcept C71924100 @default.
• W2091010250 hasConcept C98274493 @default.
• W2091010250 hasConceptScore W2091010250C159110408 @default.
• W2091010250 hasConceptScore W2091010250C169627665 @default.
• W2091010250 hasConceptScore W2091010250C170493617 @default.
• W2091010250 hasConceptScore W2091010250C181199279 @default.
• W2091010250 hasConceptScore W2091010250C185592680 @default.
• W2091010250 hasConceptScore W2091010250C193042331 @default.
• W2091010250 hasConceptScore W2091010250C202751555 @default.
• W2091010250 hasConceptScore W2091010250C2776568683 @default.
• W2091010250 hasConceptScore W2091010250C2778684643 @default.
• W2091010250 hasConceptScore W2091010250C2778938600 @default.
• W2091010250 hasConceptScore W2091010250C41685203 @default.
• W2091010250 hasConceptScore W2091010250C55493867 @default.
• W2091010250 hasConceptScore W2091010250C57992300 @default.
• W2091010250 hasConceptScore W2091010250C71240020 @default.
• W2091010250 hasConceptScore W2091010250C71924100 @default.

• next