FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091011623> ?p ?o ?g. }

• W2091011623 endingPage "76" @default.
• W2091011623 startingPage "67" @default.
• W2091011623 abstract "Effects of pertussis toxin (PTX), cholera toxin (CTX) and an anhydrolyzable GTP analogue, GTP gamma S, on the levels of free intracellular calcium ([Ca2+]i) and the production of reactive oxygen metabolites (ROM) in human polymorphonuclear leukocytes (PMNL) were studied during cell activation. Cells were stimulated by particulate stimuli, quartz or chrysotile, and soluble stimuli, formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA). Pretreatment of PMNL with PTX decreased fMLP-induced elevations of [Ca2+]i but not those induced by quartz or chrysotile. CTX, in turn, decreased both quartz- and fMLP-induced elevations of [Ca2+]i. Likewise, PTX inhibited only fMLP-induced production of ROM, whereas CTX inhibited also those induced by quartz, chrysotile or fMLP. PTX or CTX did not, however, have an impact on PMA-induced production of ROM. GTP gamma S alone did not elevate [Ca2+]i or amplify fMLP-, quartz- or chrysotile-induced [Ca2+]i elevation. However, GTP gamma S alone increased the production of ROM and amplified ROM production induced by fMLP and quartz. The present results suggest that a CTX-sensitive G-protein may be involved in quartz-induced PMNL activation whereas an fMLP-induced neutrophil activation may be regulated by G-proteins sensitive to both PTX and CTX. The involvement of G-protein in chrysotile-induced leukocyte activation is not likely. There may be, however, a relationship between G-protein-mediated cell signalling and quartz-induced production of reactive oxygen metabolites in these cells." @default.
• W2091011623 created "2016-06-24" @default.
• W2091011623 creator A5015193136 @default.
• W2091011623 date "1995-05-05" @default.
• W2091011623 modified "2023-09-25" @default.
• W2091011623 title "The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites" @default.
• W2091011623 cites W1506662402 @default.
• W2091011623 cites W1516085090 @default.
• W2091011623 cites W1518604518 @default.
• W2091011623 cites W1566015590 @default.
• W2091011623 cites W1911780819 @default.
• W2091011623 cites W1964585383 @default.
• W2091011623 cites W1964839077 @default.
• W2091011623 cites W1972362542 @default.
• W2091011623 cites W1978778326 @default.
• W2091011623 cites W1980166477 @default.
• W2091011623 cites W1985334766 @default.
• W2091011623 cites W1986450675 @default.
• W2091011623 cites W1994910145 @default.
• W2091011623 cites W2003385965 @default.
• W2091011623 cites W2003586088 @default.
• W2091011623 cites W2033844534 @default.
• W2091011623 cites W2047379485 @default.
• W2091011623 cites W2065173599 @default.
• W2091011623 cites W2071032007 @default.
• W2091011623 cites W2080875376 @default.
• W2091011623 cites W2082759239 @default.
• W2091011623 cites W2086862044 @default.
• W2091011623 cites W2093113620 @default.
• W2091011623 cites W2097936187 @default.
• W2091011623 cites W2119854649 @default.
• W2091011623 cites W2141260882 @default.
• W2091011623 cites W2146033738 @default.
• W2091011623 cites W240625612 @default.
• W2091011623 cites W2433512011 @default.
• W2091011623 cites W2468119228 @default.
• W2091011623 cites W284451419 @default.
• W2091011623 cites W44092459 @default.
• W2091011623 doi "https://doi.org/10.1016/0300-483x(94)02996-8" @default.
• W2091011623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7762003" @default.
• W2091011623 hasPublicationYear "1995" @default.
• W2091011623 type Work @default.
• W2091011623 sameAs 2091011623 @default.
• W2091011623 citedByCount "8" @default.
• W2091011623 crossrefType "journal-article" @default.
• W2091011623 hasAuthorship W2091011623A5015193136 @default.
• W2091011623 hasConcept C111963520 @default.
• W2091011623 hasConcept C118716 @default.
• W2091011623 hasConcept C134018914 @default.
• W2091011623 hasConcept C153911025 @default.
• W2091011623 hasConcept C170493617 @default.
• W2091011623 hasConcept C181199279 @default.
• W2091011623 hasConcept C185592680 @default.
• W2091011623 hasConcept C191897082 @default.
• W2091011623 hasConcept C192562407 @default.
• W2091011623 hasConcept C195794163 @default.
• W2091011623 hasConcept C2777006276 @default.
• W2091011623 hasConcept C2780043322 @default.
• W2091011623 hasConcept C48349386 @default.
• W2091011623 hasConcept C49773422 @default.
• W2091011623 hasConcept C510490043 @default.
• W2091011623 hasConcept C55493867 @default.
• W2091011623 hasConcept C62478195 @default.
• W2091011623 hasConcept C79879829 @default.
• W2091011623 hasConcept C80631254 @default.
• W2091011623 hasConcept C86803240 @default.
• W2091011623 hasConceptScore W2091011623C111963520 @default.
• W2091011623 hasConceptScore W2091011623C118716 @default.
• W2091011623 hasConceptScore W2091011623C134018914 @default.
• W2091011623 hasConceptScore W2091011623C153911025 @default.
• W2091011623 hasConceptScore W2091011623C170493617 @default.
• W2091011623 hasConceptScore W2091011623C181199279 @default.
• W2091011623 hasConceptScore W2091011623C185592680 @default.
• W2091011623 hasConceptScore W2091011623C191897082 @default.
• W2091011623 hasConceptScore W2091011623C192562407 @default.
• W2091011623 hasConceptScore W2091011623C195794163 @default.
• W2091011623 hasConceptScore W2091011623C2777006276 @default.
• W2091011623 hasConceptScore W2091011623C2780043322 @default.
• W2091011623 hasConceptScore W2091011623C48349386 @default.
• W2091011623 hasConceptScore W2091011623C49773422 @default.
• W2091011623 hasConceptScore W2091011623C510490043 @default.
• W2091011623 hasConceptScore W2091011623C55493867 @default.
• W2091011623 hasConceptScore W2091011623C62478195 @default.
• W2091011623 hasConceptScore W2091011623C79879829 @default.
• W2091011623 hasConceptScore W2091011623C80631254 @default.
• W2091011623 hasConceptScore W2091011623C86803240 @default.
• W2091011623 hasIssue "1-2" @default.
• W2091011623 hasLocation W20910116231 @default.
• W2091011623 hasLocation W20910116232 @default.
• W2091011623 hasOpenAccess W2091011623 @default.
• W2091011623 hasPrimaryLocation W20910116231 @default.
• W2091011623 hasRelatedWork W1903329796 @default.
• W2091011623 hasRelatedWork W1967541642 @default.
• W2091011623 hasRelatedWork W1968353921 @default.
• W2091011623 hasRelatedWork W2001746035 @default.
• W2091011623 hasRelatedWork W2031370301 @default.
• W2091011623 hasRelatedWork W2067847215 @default.
• W2091011623 hasRelatedWork W2091011623 @default.

• next