Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091019704> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2091019704 endingPage "199" @default.
- W2091019704 startingPage "197" @default.
- W2091019704 abstract "First-trimester megacystis is defined as enlargement of the fetal bladder, sonographically measured in the longitudinal diameter. It has been classified as being either mild (8–11 mm), moderate (12–15 mm) or severe (> 15 mm)1, 2. The concomitant finding of posterior urethral dilatation (‘keyhole’ sonographic appearance) or renal abnormalities (hydronephrosis and/or dysplastic kidneys) indicates, per se, a severe classification2. During the second and third trimester the diagnosis relies on subjective criteria2. Megacystis has been reported to be associated with various extrarenal anomalies3, megacystis–microcolon–intestinal hypoplasia syndrome4, 5 or various chromosomal aneuploidies1, 6-8. Multiple births are at higher risk for birth defects9. The risk ratio of bladder or urethra obstruction in twins over singletons is 3.34 (95% confidence intercal (CI), 1.20–9.27)9. Nevertheless, only two anecdotal cases describing megacystis in co-twins3, 5, have been reported. This motivated us to search our database of fetuses with severe abnormalities and to look for this condition among singletons and twins. Our inclusion criteria were diagnosis of a moderate to severely enlarged bladder1-3 and a gestational age of no more than 20 weeks (Figures 1 and 2)3. The current study cohort consisted of 335 consecutive pregnant women admitted to our department between January 1 1997 and April 31 2004, all of them because of severe fetal abnormalities. Three hundred and twenty were singleton pregnancies and 15 were dichorionic twin pregnancies. In every pair, only one of the fetuses had a severe abnormality (Figure 2). Karyotyping was performed in six fetuses and one case had trisomy 21 (Table 1)10. One fetus was miscarried, and the remaining affected pregnancies were interrupted following extensive counseling and upon the parents' request. In the twin pairs, selective feticide was performed and the unaffected fetus had an uneventful pregnancy outcome. Associated renal anomalies included obstructive common cloaca (Figure 1), echogenic kidneys and keyhole bladder (Table 1). When the case series' data were analyzed, it was found that megacystis was diagnosed in 7 (2%) of the singletons and in 3 (20%) of the twins from all the affected pregnancies, which represents a significantly higher rate among twin pregnancies than singletons (Table 2). Male fetus at 13 + 2 weeks' gestation showing a severely enlarged megacystis and a common cloaca (arrow) in (a) mid-sagittal and (b) transverse view. Twin pregnancy at 13 + 2 weeks' gestation. (a) Mid-sagittal section of twin showing the severely enlarged megacystis and the intertwin membrane (arrows); (b) mid-sagittal section of an apparently normal looking co-twin. Our data agree with those of previous reports3, 8 that fetal megacystis is a severe abnormality and the prognosis is dismal. This is mainly owing to a high rate of associated renal and extrarenal anomalies (5/9; 55% in our series). In agreement with Jouannic et al.3, we found no fetuses with increased nuchal translucency (NT) and we reiterate our previous recommendation to offer fetal karyotyping in cases of megacystis, irrespective of the NT or spontaneous resolution of this condition10. In agreement with Liao et al.8, it seems that megacystis is predominantly a male associated abnormality. The occurrence of this abnormality in a female fetus should alert the search for either megacystis–microcolon–intestinal hypoperistalsis or an abnormal karyotype. The incidence of discordance for birth defects in siblings from the same multiple pregnancies may be due to maternal hemodynamic or microvascular changes in the placenta, as well as nutritional supply. It has already been shown that even in genotypically identical twins, the incidence of birth defects may be discordant, pointing probably to a role for nongenetic factors in the etiology of birth defects9. We are aware that our current study is not an epidemiological one, but rather a small case series which may be subject to some bias. Nevertheless, it may prompt others to search their database for similar conditions. R. Maymon*, I. Ben-Ami*, Z. Vaknin*, O. Reish , A. Herman*, * Department of Obstetrics Gynecology, Assaf Harofeh Medical Center, Zerifin, 70300, Israel, The Genetic Institute, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel" @default.
- W2091019704 created "2016-06-24" @default.
- W2091019704 creator A5006460481 @default.
- W2091019704 creator A5030212533 @default.
- W2091019704 creator A5037885355 @default.
- W2091019704 creator A5082256702 @default.
- W2091019704 creator A5082577937 @default.
- W2091019704 date "2005-06-29" @default.
- W2091019704 modified "2023-09-27" @default.
- W2091019704 title "Is there an increased rate of megacystis in twins?" @default.
- W2091019704 cites W124800417 @default.
- W2091019704 cites W1991423355 @default.
- W2091019704 cites W2007928649 @default.
- W2091019704 cites W2021718232 @default.
- W2091019704 cites W2025633709 @default.
- W2091019704 cites W2035606659 @default.
- W2091019704 cites W2070688986 @default.
- W2091019704 cites W2076203957 @default.
- W2091019704 cites W2092483162 @default.
- W2091019704 doi "https://doi.org/10.1002/uog.1952" @default.
- W2091019704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15988735" @default.
- W2091019704 hasPublicationYear "2005" @default.
- W2091019704 type Work @default.
- W2091019704 sameAs 2091019704 @default.
- W2091019704 citedByCount "4" @default.
- W2091019704 countsByYear W20910197042017 @default.
- W2091019704 countsByYear W20910197042023 @default.
- W2091019704 crossrefType "journal-article" @default.
- W2091019704 hasAuthorship W2091019704A5006460481 @default.
- W2091019704 hasAuthorship W2091019704A5030212533 @default.
- W2091019704 hasAuthorship W2091019704A5037885355 @default.
- W2091019704 hasAuthorship W2091019704A5082256702 @default.
- W2091019704 hasAuthorship W2091019704A5082577937 @default.
- W2091019704 hasBestOaLocation W20910197041 @default.
- W2091019704 hasConcept C126322002 @default.
- W2091019704 hasConcept C131872663 @default.
- W2091019704 hasConcept C141071460 @default.
- W2091019704 hasConcept C2777085111 @default.
- W2091019704 hasConcept C2778376644 @default.
- W2091019704 hasConcept C2779234561 @default.
- W2091019704 hasConcept C2779384505 @default.
- W2091019704 hasConcept C2781040948 @default.
- W2091019704 hasConcept C29456083 @default.
- W2091019704 hasConcept C54355233 @default.
- W2091019704 hasConcept C71924100 @default.
- W2091019704 hasConcept C77411442 @default.
- W2091019704 hasConcept C86803240 @default.
- W2091019704 hasConceptScore W2091019704C126322002 @default.
- W2091019704 hasConceptScore W2091019704C131872663 @default.
- W2091019704 hasConceptScore W2091019704C141071460 @default.
- W2091019704 hasConceptScore W2091019704C2777085111 @default.
- W2091019704 hasConceptScore W2091019704C2778376644 @default.
- W2091019704 hasConceptScore W2091019704C2779234561 @default.
- W2091019704 hasConceptScore W2091019704C2779384505 @default.
- W2091019704 hasConceptScore W2091019704C2781040948 @default.
- W2091019704 hasConceptScore W2091019704C29456083 @default.
- W2091019704 hasConceptScore W2091019704C54355233 @default.
- W2091019704 hasConceptScore W2091019704C71924100 @default.
- W2091019704 hasConceptScore W2091019704C77411442 @default.
- W2091019704 hasConceptScore W2091019704C86803240 @default.
- W2091019704 hasIssue "2" @default.
- W2091019704 hasLocation W20910197041 @default.
- W2091019704 hasLocation W20910197042 @default.
- W2091019704 hasOpenAccess W2091019704 @default.
- W2091019704 hasPrimaryLocation W20910197041 @default.
- W2091019704 hasRelatedWork W2002867793 @default.
- W2091019704 hasRelatedWork W2050793495 @default.
- W2091019704 hasRelatedWork W2146312317 @default.
- W2091019704 hasRelatedWork W2333891256 @default.
- W2091019704 hasRelatedWork W2338643548 @default.
- W2091019704 hasRelatedWork W2375504484 @default.
- W2091019704 hasRelatedWork W2536473381 @default.
- W2091019704 hasRelatedWork W3136574668 @default.
- W2091019704 hasRelatedWork W3194350171 @default.
- W2091019704 hasRelatedWork W2735401012 @default.
- W2091019704 hasVolume "26" @default.
- W2091019704 isParatext "false" @default.
- W2091019704 isRetracted "false" @default.
- W2091019704 magId "2091019704" @default.
- W2091019704 workType "article" @default.