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• W2091026170 abstract "The effect of long-term exposure to tributyltin (TBT) on the intestine-related biochemical biomarkers in common carp was investigated in this study. Fish were exposed at sub-lethal concentrations of TBT (75 ng/L, 0.75 and 7.5 μg/L) for 60 days. Multiple biomarkers were measured, including digestive enzymes (trypsin, lipase and amylase), antioxidant responses (malondialdehyde (MDA) and total antioxidative capacity (T-AOC)), RNA/DNA ratio and the expression of digestive-related genes (try, lipc and amy). TBT exposure at 0.75 and 7.5 μg/L led to significantly inhibited activities of all digestive enzymes. At higher concentration of TBT, oxidative stress was apparent as reflected by the significant higher MDA content in the fish intestine, associated with an inhibition of T-AOC activities. After 60 days, the RNA/DNA ratio in fish intestine was significantly lower in groups exposed to TBT at higher concentrations (0.75 and 7.5 μg/L). In addition, the expression levels of try, lipc and amy in intestine of all treated fish were inhibited, even at the environmental concentration (75 ng/L). Our results suggest that long-term exposure to TBT could result in different responses of intestine-related biochemical biomarkers in fish, which could be used as new potential indicators for monitoring residual TBT present in aquatic environment." @default.
• W2091026170 created "2016-06-24" @default.
• W2091026170 creator A5007759634 @default.
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• W2091026170 date "2014-11-01" @default.
• W2091026170 modified "2023-10-03" @default.
• W2091026170 title "Molecular responses in digestive tract of juvenile common carp after chronic exposure to sublethal tributyltin" @default.
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• W2091026170 doi "https://doi.org/10.1016/j.ecoenv.2014.07.031" @default.
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• W2091026170 hasPublicationYear "2014" @default.
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