Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091034832> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2091034832 endingPage "229" @default.
- W2091034832 startingPage "223" @default.
- W2091034832 abstract "Abstract In dry powder formulations for inhalation, the micronized active substance is usually diluted with a mixture of coarse and fine carrier particles in order to increase its flowability and dispersion properties. Considering a selected DPI fluticasone propionate (Flp)-coarse (CL) and fine (FL) lactoses ([Pharmatose DCL 21/Microfine 80/20] 1:499 w/w) composition in terms of drug deposition, the aim of the present study was to establish the optimal blending conditions in three types of mixing equipment, and to determine the effects of FL on the mixing homogeneity and dispersibility of Flp. The Flp-lactose ternary mixtures were prepared by first premixing the two lactoses (CL/FL) in five different ratios: 100/0; 99/1; 90/10; 80/20; 0/100 (w/w). Then Flp was added and the blending was carried out at three rotational speeds (low, medium and high) in a three-dimensional motion mixer (Turbula 2C), a planetary mixer (Collette MP-20) and a high-shear (Mi-Pro) mixer. The incorporation of a large proportion of FL (20%) considerably improved the aerosol performance (FPD = 87 μg) but greatly reduced the content uniformity of Flp when the blending was performed in the Turbula mixer (relative standard deviation, RSD > 20% after 20 min irrespective of the selected speed). The achievement of a homogeneous mixture (RSD" @default.
- W2091034832 created "2016-06-24" @default.
- W2091034832 creator A5016360559 @default.
- W2091034832 creator A5028921636 @default.
- W2091034832 creator A5080756070 @default.
- W2091034832 date "2007-01-01" @default.
- W2091034832 modified "2023-09-26" @default.
- W2091034832 title "Evaluation of the content homogeneity and dispersion properties of fluticasone DPI compositions" @default.
- W2091034832 cites W193028813 @default.
- W2091034832 cites W1995197318 @default.
- W2091034832 cites W2010711415 @default.
- W2091034832 cites W2025373577 @default.
- W2091034832 cites W2037987103 @default.
- W2091034832 cites W2075452481 @default.
- W2091034832 cites W2084157372 @default.
- W2091034832 doi "https://doi.org/10.1016/s1773-2247(07)50040-7" @default.
- W2091034832 hasPublicationYear "2007" @default.
- W2091034832 type Work @default.
- W2091034832 sameAs 2091034832 @default.
- W2091034832 citedByCount "10" @default.
- W2091034832 countsByYear W20910348322012 @default.
- W2091034832 countsByYear W20910348322014 @default.
- W2091034832 countsByYear W20910348322016 @default.
- W2091034832 countsByYear W20910348322021 @default.
- W2091034832 countsByYear W20910348322022 @default.
- W2091034832 countsByYear W20910348322023 @default.
- W2091034832 crossrefType "journal-article" @default.
- W2091034832 hasAuthorship W2091034832A5016360559 @default.
- W2091034832 hasAuthorship W2091034832A5028921636 @default.
- W2091034832 hasAuthorship W2091034832A5080756070 @default.
- W2091034832 hasConcept C105795698 @default.
- W2091034832 hasConcept C113196181 @default.
- W2091034832 hasConcept C126322002 @default.
- W2091034832 hasConcept C142259097 @default.
- W2091034832 hasConcept C185592680 @default.
- W2091034832 hasConcept C192562407 @default.
- W2091034832 hasConcept C2776042228 @default.
- W2091034832 hasConcept C2781212218 @default.
- W2091034832 hasConcept C33923547 @default.
- W2091034832 hasConcept C43617362 @default.
- W2091034832 hasConcept C71924100 @default.
- W2091034832 hasConceptScore W2091034832C105795698 @default.
- W2091034832 hasConceptScore W2091034832C113196181 @default.
- W2091034832 hasConceptScore W2091034832C126322002 @default.
- W2091034832 hasConceptScore W2091034832C142259097 @default.
- W2091034832 hasConceptScore W2091034832C185592680 @default.
- W2091034832 hasConceptScore W2091034832C192562407 @default.
- W2091034832 hasConceptScore W2091034832C2776042228 @default.
- W2091034832 hasConceptScore W2091034832C2781212218 @default.
- W2091034832 hasConceptScore W2091034832C33923547 @default.
- W2091034832 hasConceptScore W2091034832C43617362 @default.
- W2091034832 hasConceptScore W2091034832C71924100 @default.
- W2091034832 hasIssue "3" @default.
- W2091034832 hasLocation W20910348321 @default.
- W2091034832 hasOpenAccess W2091034832 @default.
- W2091034832 hasPrimaryLocation W20910348321 @default.
- W2091034832 hasRelatedWork W1983583026 @default.
- W2091034832 hasRelatedWork W1990688219 @default.
- W2091034832 hasRelatedWork W2021177491 @default.
- W2091034832 hasRelatedWork W2043533979 @default.
- W2091034832 hasRelatedWork W2093710999 @default.
- W2091034832 hasRelatedWork W2936438071 @default.
- W2091034832 hasRelatedWork W2945498905 @default.
- W2091034832 hasRelatedWork W2965306756 @default.
- W2091034832 hasRelatedWork W4361294988 @default.
- W2091034832 hasRelatedWork W1968862920 @default.
- W2091034832 hasVolume "17" @default.
- W2091034832 isParatext "false" @default.
- W2091034832 isRetracted "false" @default.
- W2091034832 magId "2091034832" @default.
- W2091034832 workType "article" @default.